A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
L002 is an inhibitor of p300 histone acetyltransferase with IC50 value of 1.98 μM in vitro, which is a lysine acetyltransferase that catalyzes acetyl group attachment to lysine residues of a variety of proteins. It has weaker inhibitory effects against PCAF and GCN5. It acts as a critical coactivator of several oncogenic transcription factors involved in cancer cell survival and proliferation. It blocks acetylation of histones and p53, and reduces STAT3 phosphorylation in MDA-MB-468 xenografts, leukemia and lymphoma cell lines. It induces growth arrest and apoptosis in certain cancer cell lines and suppresses the growth of triple-negative breast cancer xenografts. Synonyms: 2,6-Dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime]; 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione; NSC764414; NSC 764414; NSC-764414; L002; L 002; L-002. Grades: ≥98% by HPLC. CAS No. 321695-57-2. Molecular formula: C15H15NO5S. Mole weight: 321.35.
L002
L002. Group: Biochemicals. Grades: Purified. CAS No. 321695-57-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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L006235
Potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence. Synonyms: L-006235; L 006235; Benzamide, N-[1-[[ (cyanomethyl) amino]carbonyl]cyclohexyl]-4-[2- (4-methyl-1-piperazinyl) -4-thiazolyl]-. Grades: 98%. CAS No. 294623-49-7. Molecular formula: C24H30N6O2S. Mole weight: 466.60.
L 006235
L 006235. Group: Biochemicals. Grades: Purified. CAS No. 294623-49-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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L 012 sodium salt
Luminal-based chemiluminescent probe. Detects NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS). Active in vitro and in vivo. Group: Biochemicals. Alternative Names: 8-Amino-5-chloro-2,3-dihydro-7-phenyl-pyrido[3,4-d]pyridazine sodium salt. Grades: Purified. CAS No. 143556-24-5. Pack Sizes: 10mg. US Biological Life Sciences.
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L-[1-13C]ribose
L-[1-13C]ribose. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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L-[1-13C]Xylose
L-[1-13C]Xylose. Group: Biochemicals. Grades: Highly Purified. CAS No. 178101-87-6. Pack Sizes: 5mg. Molecular Formula: C413CH10O5, Molecular Weight: 151.12. US Biological Life Sciences.
L-[13C5]Xylose. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: 13C5H10O5, Molecular Weight: 155.1. US Biological Life Sciences.
Worldwide
L-152,804
L-152,804. Group: Biochemicals. Grades: Purified. CAS No. 6508-43-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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L-152,804
L-152,804 is a potent and selective orally available non-peptide neuropeptide Y Y5 receptor antagonist with Ki value of 26 nM for hY5. It displays > 300-fold selectivity over hY1, hY2, and hY4 receptors. It is centrally active upon oral administration in vivo. It causes weight loss in diet-induced obese mice by inducing a potent reduction of food intake in rodents. Synonyms: L-152,804; L 152,804; L152,804; 5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione; 9-(4,4-Dimethyl-2,6-dioxocyclohexyl)-1,2,3,4-tetrahydro-3,3-dimethyl-1-xanthenone; 9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexenyl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-one; L-152804; L152804. Grades: ≥99% by HPLC. CAS No. 6508-43-6. Molecular formula: C23H26O4. Mole weight: 366.46.
L-156602
L-156602 is extracted from Streptomyces sp. MA6348, and it is the antagonist of Anaphylatoxin C5a. It is also a cyclic depsipeptide antibiotic that is active against Gram-positive bacteria. Synonyms: Antibiotic L 156602; Antibiotic PD-124966; GNF-Pf-75; L 156602; PD-124966; (3S)-3-hydroxy-N-[(2S)-2-hydroxy-1-oxo-2-[(2R,5R,6R)-tetrahydro-2-hydroxy-6-methyl-5-[(2S)-2-methylbutyl]-2H-pyran-2-yl]propyl]-L-leucyl-(3R)-hexahydro-3-pyridazinecarbonyl-N-hydroxy-L-alanylglycyl-(3S)-hexahydro-3-pyridazinecarbonyl-N-hydroxy-D-alanine, (6?13)-lactone. Grades: >95% by HPLC. CAS No. 125228-51-5. Molecular formula: C38H64N8O13. Mole weight: 840.96.
L-161,982
L-161,982. Group: Biochemicals. Grades: Purified. CAS No. 147776-06-5. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
L-161,982
L-161,982 is a selective and potent EP4 receptor antagonist with Ki value of 0.024 μM. It is selective over all other members of the prostanoid receptor family with Ki values of 19, 23 and 1.90μM for human EP1, EP2 and EP3 receptors respectively. It suppresses PGE2-induced bone formation in young rats at 10 mg/kg/day and prevents the nociceptive response induced by misoprostol in formalin-injected mice. It reverses the anti-inflammatory action of PGE2 in LPS-activated human macrophages at 100 nM. It blocks PGE2-induced cell proliferation in HCA-7 colon cancer cells at 10 μM. Synonyms: L-161,982; L 161,982; L161,982; N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide. Grades: ≥99% by HPLC. CAS No. 147776-06-5. Molecular formula: C32H29F3N4O4S2. Mole weight: 654.72.
L-161,982 (L-161982, CHEMBL1395820)
L-161,982 (L-161982, CHEMBL1395820). Group: Biochemicals. Alternative Names: N- [2- [4- [ [3-butyl-5-oxo-1- [2- (trifluoromethyl) phenyl] -1, 2, 4-triazol-4-yl] methyl] phenyl] phenyl] sulfonyl-3-methylthiophene-2-carboxamide. Grades: Highly Purified. CAS No. 147776-06-5. Pack Sizes: 10mg. Molecular Formula:C32H29F3N4O4S2 , 654.2. US Biological Life Sciences.
Worldwide
L162441
An antagonist of Angiotensin type 1 receptor. Synonyms: L162441; L 162441; L-162441; butyl N- [2- [4- [ [2-butyl-5-methyl-6- (pentanoylamino) imidazo [4, 5-b] pyridin-3-yl] methyl] phenyl] phenyl] sulfonylcarbamate. CAS No. 154512-46-6. Molecular formula: C34H43N5O5S. Mole weight: 633.8.
L-165041
L-165041 is a cell permeable PPARδ agonist which induces adipocyte differentiation in NIH-PPARδ cells. It displays more than 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. It reduces lipid accumulation in the liver and decreases total hepatic cholesterol and triglyceride content. It also raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Uses: For research used only. Synonyms: L-165041; L165041; L 165041; L-165,041; L165,041; L 165,041. Grades: >98%. CAS No. 79558-09-1. Molecular formula: C22H26O7. Mole weight: 402.44.
L-165,041
L-165,041. Group: Biochemicals. Grades: Purified. CAS No. 79558-09-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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L-168,049
L-168,049. Group: Biochemicals. Grades: Purified. CAS No. 191034-25-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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L-168,049
L-168,049 is a non-peptidyl, very selective and potent human glucagon receptor (hGR) antagonist. It displays high affinity to human GR with IC50 value of 3.7 nM, but shows moderate affinity for murine and canine GRs. It inhibits glucagon-stimulated cAMP synthesis in murine liver membranes and in CHO cells expressing hGR. It is orally active in vivo. Synonyms: L-168,049; L 168,049; L168,049; 2-(4-Pyridyl)-5-(4-chlorophenyl)-3-(5-bromo-2-propyloxyphenyl)pyrrole; 4-[3-(5-Bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine. Grades: ≥99% by HPLC. CAS No. 191034-25-0. Molecular formula: C24H20BrClN2O. Mole weight: 467.79.
l189
L189 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer. Group: Inhibitors. CAS No. 64232-83-3. Molecular formula: C11H10N4OS?xH2O. Mole weight: C11H10N4OS. Appearance: Solid. Purity: ≥98.0%. Canonical SMILES: OC1=NC(S)=NC(N)=C1/N=C/C2=CC=CC=C2. Catalog: ACM64232833.
L189
L189. Group: Biochemicals. Grades: Purified. CAS No. 64232-83-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
L189
L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. Synonyms: L189; L 189; L-189. Grades: 98%. CAS No. 64232-83-3. Molecular formula: C11H10N4OS. Mole weight: 246.29.
L-[2-13C]Xylose
L-[2-13C]Xylose. Group: Biochemicals. Grades: Highly Purified. CAS No. 478506-63-7. Pack Sizes: 5mg. Molecular Formula: C413CH10O5, Molecular Weight: 151.12. US Biological Life Sciences.
Worldwide
L-2286
L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury. Synonyms: L 2286; L2286; 2-(2-piperidin-1-ylethylsulfanyl)-1H-quinazolin-4-one. Grades: 98%. CAS No. 684276-17-3. Molecular formula: C15H19N3OS. Mole weight: 289.40.
L-2,2-Dimethyl-thiaproline hydrochloride
L-2,2-Dimethyl-thiaproline hydrochloride. Group: Biochemicals. Alternative Names: 2,2-Dimethyl-L-Thz-OH·HCl. Grades: Highly Purified. CAS No. 213475-47-9. Pack Sizes: 10g, 25g. US Biological Life Sciences.
L-2,2-Dimethylthiazolidine-4-carboxylic Acid Hydrochloride is a chiral thiazolidine used in the preparation of cysteine-derived diketopiperazines and pseudoproline-containing analogs of insect kinin core pentapeptide. Group: Biochemicals. Alternative Names: (4R)-2,2-Dimethyl-4-thiazolidinecarboxylic Acid Hydrochloride; (R)-2,2-Dimethyl-4-thiazolidinecarboxylic Acid Hydrochloride. Grades: Highly Purified. CAS No. 67089-92-3. Pack Sizes: 1g. US Biological Life Sciences.
L-2,2-Dimethylthiazolidine-4-carboxylic Acid Methyl Ester is a chiral thiazolidine used in the preparation of bicyclomycin. Group: Biochemicals. Alternative Names: (4R)-2,2-Dimethylthiazolidine-4-carboxylic Acid Methyl Ester; (R)-2,2-Dimethylthiazolidine-4-carboxylic Acid Methyl Ester. Grades: Highly Purified. CAS No. 19907-59-6. Pack Sizes: 1g. US Biological Life Sciences.
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L(+)-2,3-Diaminopropionic acid HCl
L(+)-2,3-Diaminopropionic acid HCl. Group: Biochemicals. Grades: Highly Purified. CAS No. 1482-97-9. Pack Sizes: 5g, 10g, 25g, 50g, 100g. US Biological Life Sciences.
. Uses: A pharmacological tool and potential chiral building block. it is also used as an internal standard for amino acid analysis. also found to inhibit gaba transaminase, thus producing an elevation of gaba level, and to have an antitumor activity in vitro a. Synonyms: L-Dab-OH 2HCl; (S)-2,4-Diaminobutyric acid dihydrochloride. Grades: ≥ 98% (HPLC). CAS No. 1883-09-6. Molecular formula: C4H10N2O2·2HCl. Mole weight: 191.14.
L-2,4-Diaminobutyric Acid, Dihydrochloride
A pharmacological tool and potential chiral. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences.
L-2,4-Dinitrophenylalanine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g. US Biological Life Sciences.
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L-2-(5-Bromothienyl)alanine
L-2-(5-Bromothienyl)alanine. Group: Biochemicals. Alternative Names: L-Thi(5-Br)-OH; L-a-(5-Bromothienyl)alanine. Grades: Highly Purified. CAS No. 154593-58-5. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences.
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L-2-(5-Bromothienyl)alanine 99+% (HPLC)
L-2-(5-Bromothienyl)alanine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
L-2,5-Dihydrophenylalanine
It is produced by the strain of Streptomyces sp. L-2,5-Dihydrophenylalanine can cause apoptosis of HL-60 in human myeloblastoid leukemia cells. Synonyms: 2,5-Dihydrophenylalanine; 2,5-dihydrophenyl-L-alanine; L-3-(2,5-Cyclohexadienyl)alanine. CAS No. 16055-12-2. Molecular formula: C9H13NO2. Mole weight: 167.20.
L-2,6-Dichlorophenylalanine
Heterocyclic Organic Compound. Alternative Names: L-2,6-Dichlorophenylalanine. CAS No. 111119-37-0. Molecular formula: C9H9Cl2NO2. Mole weight: 234.07926. Catalog: ACM111119370.
L-2',6'-Dimethyltyrosine
L-2',6'-Dimethyltyrosine (Dmt) enhances receptor affinity, functional bioactivity and in vivo analgesia of opioid peptides. Group: Biochemicals. Grades: Highly Purified. CAS No. 123715-02-6. Pack Sizes: 100mg, 500mg. Molecular Formula: C11H15NO3, Molecular Weight: 209.24. US Biological Life Sciences.
Worldwide
L-2-Allylglycine Hydrochloride
L-2-Allylglycine Hydrochloride. Group: Biochemicals. Alternative Names: (S)-2-Amino-4-pentenoic Acid Hydrochloride. Grades: Highly Purified. CAS No. 195316-72-4. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. US Biological Life Sciences.
L-2-Amino-4-bromo-4-pentenoic acid. Group: Biochemicals. Grades: Reagent Grade. CAS No. 151144-96-6. Pack Sizes: 1g, 5g. US Biological Life Sciences.
Worldwide
L(+)-2-Amino-4-bromobutyric acid HBr
L(+)-2-Amino-4-bromobutyric acid HBr. Group: Biochemicals. Grades: Highly Purified. CAS No. 15159-65-6. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C4H8BrNO2HBr. US Biological Life Sciences.
Worldwide
L-2-amino-4-chloropent-4-enoate dehydrochlorinase
This enzyme belongs to the family of lyases, specifically the class of carbon-halide lyases. Group: Enzymes. Synonyms: L-2-amino-4-chloro-4-pentenoate dehalogenase; L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating); L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming). Enzyme Commission Number: EC 4.5.1.4. CAS No. 113066-37-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5346; L-2-amino-4-chloropent-4-enoate dehydrochlorinase; EC 4.5.1.4; 113066-37-8; L-2-amino-4-chloro-4-pentenoate dehalogenase; L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating); L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming). Cat No: EXWM-5346.