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| Product | Description | |
|---|---|---|
| L-685,458 | L-685,458 is a potent and selective inhibitor of γ-secretase (IC50 = 17 nM) that shows 50-fold selectivity over a variety of aspartyl proteases. It also inhibits Aβ40 and Aβ42 peptides (in human neuroblastoma cells: IC50=48 and 67 nM respectively). Uses: Gamma secretase inhibitors and modulators. Synonyms: L-685458; tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate. Grades: >98%. CAS No. 292632-98-5. Molecular formula: C39H52N4O6. Mole weight: 672.85. |  |
| L-685,458 ((5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide) | Cell-permeable. A potent and selective γ-secretase inhibitor (IC50 = 17 nM). Displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A β40 and A β42 peptides (IC50 values are 48 and 67nM respectively in human neuroblastoma cells). Group: Biochemicals. Alternative Names: (5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide. Grades: Highly Purified. CAS No. 292632-98-5. Pack Sizes: 250ug. US Biological Life Sciences. |  Worldwide |
| L 687781 | L 687781, an inhibitor of β-1,3-D-glucan synthase, is originally isolated from Dictyochaeta simplex. It also has anti-Candida fungal activity and has some effects on Pneumocystis carinii. Synonyms: Hexopyranose, 1,6'-anhydro-1-C-(2,4-dihydroxy-6-(hydroxymethyl)phenyl)-4-O-(6-O-(8-hydroxy-1-oxo-2,4-decadienyl)hexopyranosyl)-, 3-(7-hydroxy-8,14-dimethyl-1-oxo-2,4,6,8,10-hexadecapentaenoate). CAS No. 130304-58-4. Molecular formula: C47H66O17. Mole weight: 903.01. | |
| L-689502 | A potent inhibitor of HIV-l protease (IC50= 1 nM). Synonyms: L 689502; L-689502; L689502; L-689,502; L 689,502; L689,502; tert-butyl N-[(2S,3S,5R)-3-hydroxy-6-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-[[4-(2-morpholin-4-ylethoxy)phenyl]methyl]-6-oxo-1-phenylhexan-2-yl]carbamate; L 689502; L-689,502. Grades: ≥98% (HPLC). CAS No. 138483-63-3. Molecular formula: C39H51N3O7. Mole weight: 673.84. | |
| L-689,560 | L-689,560 is a potent antagonist at the glycine-NMDA receptor site. It is a bioactive chemical. Synonyms: L689560; L 689560; L-689560; trans-(±)-5,7-Dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-2-quinolinecarboxylic Acid; rel-(2R,4S)-5,7-Dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-2-quinolinecarboxylic Acid; (2R,4S)-rel-5,7-Dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-2-quinolinecarboxylic Acid; trans-5,7-Dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-2-quinolinecarboxylic Acid; trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline; (2S,4R)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid. Grades: ≥99% by HPLC. CAS No. 139051-78-8. Molecular formula: C17H15Cl2N3O3. Mole weight: 380.23. | |
| L-689,560 | L-689,560. Uses: For analytical and research use. Group: Impurity standards. CAS No. 139051-78-8. Molecular Formula: C17H15Cl2N3O3. Mole Weight: 380.23. Catalog: APB139051788. |  |
| L-690,330 | L-690,330 is a potent inositol monophophatase (IMPase) inhibitor in vitro and in vivo. It induces autophagy in COS-7 cells independently of mTOR inhibition. It is stable to hydrolysis. Synonyms: L690330; L 690330; L-690330. [1- (4-Hydroxyphenoxy) ethylidene]bisphosphonic Acid; P, P'-[1- (4-Hydroxyphenoxy) ethylidene]bis[phosphonic acid]; L 690330. CAS No. 142523-38-4. Molecular formula: C8H12O8P2. Mole weight: 298.13. | |
| L-690,488 | L-690,488 is a cell-permeable prodrug of the L-690,330, which is a potent bisphosphonate inositol monophophatase inhibitor. It penetrates cells more effectively than its metabolite. Synonyms: L-690,488; L 690,488; L690488; L 690488; 1-[ (4-Hydroxyphenoxy) ethylidene]bis[phosphinylidynebis (oxymethylene) ]-2, 2-dimethylpropanoate. Grades: ≥98% by HPLC. CAS No. 142523-14-6. Molecular formula: C32H52O16P2. Mole weight: 754.70. | |
| L 691816 | L 691816 is a 5-lipoxygenase (5-LO) inhibitor. Synonyms: 1-(4-Chlorobenzyl)-2-(2,2-Dimethyl-3-(1H-Tetrazol-5-Yl)Propyl)-4-Methyl-6-((5-Phenylpyridin-2-Yl)Methoxy)-4,5-Dihydro-1H-Thiopyrano[2,3,4-Cd]Indole; L-691816; L691816. Grades: ≥98% by HPLC. CAS No. 150461-07-7. Molecular formula: C36H35ClN6OS. Mole weight: 635.2. | |
| L-692,585 | L-692,585 is a non-peptide, highly potent and selective ghrelin receptor (GHS-R1a) agonist with Ki value of 0.8 nM. It shows GH-secretory activity in several species including human. It increases plasma GH levels in vivo and is 2-2.5-fold more potent than GHRP-6. Synonyms: 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide; [R-(R*,R*)]-3-[(2-hydroxypropyl)amino]-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide; 1H-1-Benzazepine, Butanamide derivative; L 692585; L692585; L-692585. Grades: ≥98% by HPLC. CAS No. 145455-35-2. Molecular formula: C32H37N7O3. Mole weight: 567.69. | |
| L-692,585 | L-692,585. Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-692585, L-692,585, SureCN7474014, CHEMBL13600, CTK8E6841, HMS3268F14, NCGC00159545-01, BRD-K70241288-001-01-1, 145455-35-2. Product Category: Heterocyclic Organic Compound. CAS No. 145455-35-2. Molecular formula: C32H37N7O3. Mole weight: 567.69. Purity: >98 %. IUPACName: 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide. Canonical SMILES: CC(CNC(C)(C)CC(=O)NC1CCC2=CC=CC=C2N(C1=O)CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)O. Density: 1.31g/cm³. Product ID: ACM145455352. Alfa Chemistry ISO 9001:2015 Certified. |  |
| L-692,585 | L-692,585. Group: Biochemicals. Grades: Purified. CAS No. 145455-35-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| L-693,403 maleate | L-693,403 maleate is the maleate salt of L-693,403, which is a sigma receptor-binding compound. It has excellent selectivity over the dopamine D2 receptor and belongs high affinity σ ligand. It is used for the treatment of diabetes-associated pain. Synonyms: L-693,403 maleate; L 693,403 maleate; L693,403 maleate; N-1'-Benzyl-3,4-dihydrospiro[1H-indene-1,4'-piperidine] Maleate; 2,3-Dihydro-1'-(phenylmethyl)-spiro[1H-indene-1,4'-piperidine] (Z)-2-Butenedioate. CAS No. 207455-21-8. Molecular formula: C24H27NO4. Mole weight: 393.48. | |
| L-694,247 | L-694,247 is a highly selective and extremely potent 5-HT1D receptor agonist. Synonyms: L-694,247; L 694,247; L694,247. N-[4-[[5-[3-(2-aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]methanesulfonamide; 2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine. Grades: ≥98% by HPLC. CAS No. 137403-12-4. Molecular formula: C20H21N5O3S. Mole weight: 411.48. | |
| L-696474 | L-696474 is extracted from Hypoxylon fragiforme MF5511. It can competitively inhibit the action of HIV-1 protease with an IC50 of 3 μmol/L. Synonyms: L-696,474; 18-dehydroxycytochalasin H. Grades: >98% by HPLC. CAS No. 141994-72-1. Molecular formula: C30H39NO4. Mole weight: 477.63. | |
| L-701,252 | L-701,252 is an antagonist at the glycine-NMDA site with IC50 value of 420 nM. It is used as a potent systemic anticonvulsant. Synonyms: L-701,252; L 701,252; L701,252; 7-Chloro-3-(cyclopropylcarbonyl)-4-hydroxy-2(1H)-quinolinone. Grades: ≥99% by HPLC. CAS No. 151057-13-5. Molecular formula: C13H10ClNO3. Mole weight: 263.68. | |
| L-701,324 | L-701,324 is a selective antagonist at the glycine site of the NMDA glutamate receptor. L-701,324 shows a beneficial action in the animal model of parkinsonian rigidity. L-701,324 is also a anticonvulsant which has a reduced propensity to activate mesolimbic dopaminergic systems in rodents. Preclinical trials for the treatment of Anxiety disorders, Epilepsy, Major depressive disorder and Psychotic disorders were discontinued. Uses: Anxiety disorders; epilepsy; major depressive disorder; psychotic disorders. Synonyms: L701324; L 701324; L-701324; L701324; L 701324; L-701324; 7-CHLORO-4-HYDROXY-3-(3-PHENOXY)PHENYL-2(1H)-QUINOLINONE;7-CHLORO-4-HYDROXY-3-(3-PHENOXY )PHENYLQUINOLIN-2[1H]-ONE. Grades: 98 %. CAS No. 142326-59-8. Molecular formula: C21H14ClNO3. Mole weight: 363.79. | |
| L-701,324 (7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone) | A highly potent and selective antagonist for thenMDA receptor glycine site (IC50 = 2.0nM; Kd = 28nM; ED50 = 0.9nM either intraperitoneal (ip) or oral (po) adminited). The first such compounds with significant activity in the central nervous system following oral dosing and a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. Group: Biochemicals. Grades: Highly Purified. CAS No. 142326-59-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| L-703,664 succinate | L-703,664 succinate is the succinate salt of L-703,664, which is a 5-HT1D receptor agonist. It shows selectivity over other 5-HT receptor subtypes and other receptors. Synonyms: L-703,664 succinate; L 703,664 succinate; L703664 succinate; N,N-Dimethyl-5-[(5-methyl-1,2,5-thiadiazolidin-2-yl)methyl]-S,S-dioxide-1H-indole-3-ethanamine Butanedioate; N,N-Dimethyl-5-[(5-methyl-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole-3-ethanamine Butanedioate; 1H-Indole-3-ethanamine-1,2,5-thiadiazolidine Derivative; N,N-Dimethyl-5-[(5-methyl-1,1-dioxodo-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole-3-ethanamine succinate. Grades: ≥99% by HPLC. CAS No. 144776-01-2. Molecular formula: C20H30N4O6S. Mole weight: 454.54. | |
| L-732,138 | L-732,138 is a highly selective and potent substance P (SP) receptor antagonist. It is also a potent and competitive tachykinin NK1 receptor antagonist with IC50 value of 2.3 nM. It is also approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors. Synonyms: 3,5-bis(TFM)Bz NAcTrp; L732138; L 732138; L-732138; L-732, 138; N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl Ester; N-Acetyltryptophan 3,5-bis(trifluoromethyl)benzyl Ester. Grades: ≥98% by HPLC. CAS No. 148451-96-1. Molecular formula: C22H18F6N2O3. Mole weight: 472.39. | |
| L-733,060 | L-733,061, a phenylpiperidine derivative, has been found to be a NK1 receptor antagonist that could probably be antidepressant/ anxiolytic agent and also show antitumor activity at some extent. Uses: Neurokinin-1 receptor antagonists. Synonyms: L-733060; L 733060; L 733061; L-733061; L 733,060; L 733,061; (2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine. Grades: 98%. CAS No. 148700-85-0. Molecular formula: C20H19F6NO. Mole weight: 403.36. | |
| L-733,060 hydrochloride | The hydrochloride salt form of L-733,061, a phenylpiperidine derivative, has been found to be a NK1 receptor antagonist that could probably be antidepressant/ anxiolytic agent and also show antitumor activity at some extent. Ki: 0.08, 0.2 and 93.13 nM for gerbil, human and rat receptors, respectively. Synonyms: L-733,061 hydrochloride; MLS-002153399; L-733,060 hydrochloride; L 733,061 hydrochloride; MLS 002153399; L 733,060 hydrochloride; L733,061 hydrochloride; MLS002153399; L733,060 hydrochloride; L733061 hydrochloride; L733060 hydrochloride; (2R,3R)-3-[(3,5-bis(Trifluoromethyl)phenyl)methoxy]-2-phenylpiperidine hydrochloride; SMR001230778. Grades: 98%. CAS No. 148687-76-7. Molecular formula: C20H19F6NO.HCl. Mole weight: 439.82. | |
| L-733060 hydrochloride | L-733060 hydrochloride is a potent tachykinin NK 1 receptor antagonist. L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 148687-76-7. Pack Sizes: 1 mg. Product ID: HY-14406A. |  |
| L-741,626 | L-741,626 is a selective and potent D2 dopamine receptor antagonist. It is centrally active following systemic administration in vivo. It inhibits quinpirole-stimulated mitogenesis transfected with human D2 and D3 receptors in a functional assay. It reversibly blocks D2-mediated currents in Xenopus oocytes by G protein-gated inwardly rectifying K+ (GIRK) channels. It inhibits the conditioned avoidance response (CAR) in rats and apomorphine-induced climbing behavior in mice. It evokes a catalepsy response and blocks gnawing induced by methylphenidate in rat models of potential extrapyramidal activity. Uses: Dopamine antagonists. Synonyms: L-741,626; L741,626; L 741,626; 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)-4-piperidinol; 3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole; 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidin-4-ol; (±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole. Grades: ≥98% by HPLC. CAS No. 81226-60-0. Molecular formula: C20H21ClN2O. Mole weight: 340.85. | |
| L-741,626 (Dopamine D2 Receptor Antagonist, L-741,626, L-741626, L741626) | Selective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1nM), D3R (155nM), D4R (596nM). Commonly used D2 inhibitor in addiction research. Group: Biochemicals. Grades: Highly Purified. CAS No. 81226-60-0. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O. US Biological Life Sciences. | Worldwide |
| L-741,742 hydrochloride | L-741,742 hydrochloride is the hydrochloride salt of L-741,742, which is a highly selective and potent D4 dopamine receptor antagonist with Ki value of 3.5 nM at cloned human D4 receptors. It is used in the treatment of psychological diseases such as schizophrenia and depression. Synonyms: L-741,742 hydrochloride; L741,742 hydrochloride; L 741,742 hydrochloride; 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride. Grades: ≥98% by HPLC. CAS No. 874882-93-6. Molecular formula: C23H26N2Cl2O. Mole weight: 417.38. | |
| L-742001 hydrochloride | L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC 90 of 4.3 μM for vRNP activity in HEK293T cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 174605-64-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-118368. | |
| L-744832 | L-744832, also known as L-744,832, is a potent Farnesyltransferase inhibitor with potential anticancer activity. Synonyms: L 744832; L744832; (2S)-2-[[2-[(2S,3S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylpentoxy]-1-oxo-3-phenylpropyl]amino]-4-methylsulfonylbutanoic acid propan-2-yl ester. CAS No. 160141-09-3. Molecular formula: C26H45N3O6S2. Mole weight: 559.78. | |
| L-744832 ((2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride) | Ras farnesyltransfer. Group: Biochemicals. Alternative Names: (2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| L-745870 | L-745870 is a potent, selective, brain-penetrant and orally active dopamine D 4 receptor antagonist with a K i of 0.43 nM. L-745870 shows weaker affinity for D 2 ( K i of 960 nM) and D 3 ( K i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT 2 receptors, sigma sites and α-adrenoceptors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 158985-00-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14325. | |
| L-745870 hydrochloride | L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D 4 receptor antagonist with a K i of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D 2 ( K i of 960 nM) and D 3 ( K i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT 2 receptors, sigma sites and α-adrenoceptors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1173023-36-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14325B. | |
| L-745,870 trihydrochloride | L-745,870 trihydrochloride is the trihydrochloride salt of L-745,870, which is highly selective and potent D4 dopamine receptor antagonist with Ki value of 0.51nM. It is > 1000-fold selective over 5-HT2, D1 and D5 receptors. It has antipsychotic effects in animal models, but it was not effective in human trials. Synonyms: L-745,870 trihydrochloride; L 745,870 trihydrochloride; L745,870 trihydrochloride; 3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride. Grades: ≥99% by HPLC. CAS No. 866021-03-6. Molecular formula: C18H22N4Cl2. Mole weight: 436.21. | |
| L-745,870 Trihydrochloride (Dopamine D4 Receptor Antagonist, L-745,870 Trihydrochloride, L-745870, L745870) | Selective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation. Group: Biochemicals. Grades: Highly Purified. CAS No. 158985-00-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| L-748,337 | L-748,337 is a selective and competitive β3-adrenoceptor antagonist with Ki value of 4.0 nM. It can inhibit agonist-induced relaxation of smooth muscle and lipolysis in rhesus monkey adipocytes. It also inhibits cAMP accumulation in response to isoproterenol. It reduces apoptosis, iNOS expression and attenuates nitric oxide-induced cell proliferation in a melanoma cell line. Synonyms: L-748337; L 748337; L748337. N- [ [3- [ (2S) -2-Hydroxy-3- [ [2- [4- [ (phenylsulfonyl) amino] phenyl] ethyl] amino] propoxy] phenyl] methyl] -acetamide. Grades: ≥98% by HPLC. CAS No. 244192-94-7. Molecular formula: C26H31N3O5S. Mole weight: 497.61. | |
| L-748,337 | L-748,337. Group: Biochemicals. Grades: Purified. CAS No. 244192-94-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| L-755507 | L-755,507 is a potent, selective and novel β3-adrenergic receptor (β3-AR) partial agonist with an EC50 value of 0.43 nM. It is over 440-fold selectivity for β3 compared to β1 and β2-adrenergic receptor binding. It has been used to enhance CRISPR-mediated homology-directed repair efficiency for large fragment insertions and for point mutations at 5 μM in human induced pluripotent stem cells. It also has been used to identify signaling pathways activated through β3-adrenergic receptors. It stimulates lipolysis in rhesus adipocytes in vitro. It may also serve as a potential therapeutic target for the treatment of type II diabetes and obesity. Synonyms: L-755507; L 755507; L755507; 4- [ [ (Hexylamino) carbonyl] amino] -N- [4- [2- [ [ (2S) -2-hydroxy-3- (4-hydroxyphenoxy) propyl] amino] ethyl] phenyl] benzenesulfonamide; (S) -4- [ [ (Hexylamino) carbonyl] amino] -N- [4- [2- [ [2-hydroxy-3- (4-hydroxyphenoxy) propyl] amino] ethyl] phenyl] benzenesulfonamide; 1-Hhexyl-3- [4- [ [4- [2- [ [ (2S) -2-hydroxy-3- (4-hydroxyphenoxy) propyl] amino] ethyl] phenyl] sulfamoyl] phenyl] urea. Grades: ≥98% by HPLC. CAS No. 159182-43-1. Molecular formula: C30H40N4O6S. Mole weight: 584.73. | |
| L-755,507 | Potent beta3-adrenergic receptor partial agonist > 1000-fold selective over beta1- and beta2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human beta3-, beta1- and beta2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs). Group: Biochemicals. Alternative Names: 4- [ [ (Hexylamino) carbonyl] amino] -N- [4- [2- [ [ (2S) -2-hydroxy-3- (4-hydroxyphenoxy) propyl] amino] ethyl] phenyl] benzenesulfonamide; (S) -4- [ [ (Hexylamino) carbonyl] amino] -N- [4- [2- [ [2-hydroxy-3- (4-hydroxyphenoxy) propyl] amino] ethyl] phenyl] benzenesulfonamide. Grades: Highly Purified. CAS No. 159182-43-1. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 584.73. US Biological Life Sciences. | Worldwide |
| L-759,633 | L-759,633 is a potent cannabinoid receptor (CB2) agonist with 163-fold selectivity for CB2 over CB1. L-759,633 exhibits great potency against forskolin-stimulated cyclic AMP production in CB2-transfected cells than in CB1-transfected cells. Synonyms: (6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene. Grades: ≥98%. CAS No. 174627-50-0. Molecular formula: C26H40O2. Mole weight: 384.6. | |
| L760735 | L760735 is a high-affinity NK1 receptor antagonist with IC50 value of 0.19 nM. It is selective over NK2 and NK3 receptors. It is used in the synthetic preparation of a (triazolylmethyl)morpholine derivative as substance P antagonist. It has anxiolytic and antidepressant-like effects and is orally active. Synonyms: L760735; L 760735; L-760735; 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine Hydrochloride; [2R-[2α(R*),3α]]-5-[[2-[1-[3,5-bis(Trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine Monohydrochloride. Grades: ≥99% by HPLC. CAS No. 188923-01-5. Molecular formula: C26H29F7N5O2Cl. Mole weight: 611.98. | |
| L 760735 | L 760735. Group: Biochemicals. Grades: Purified. CAS No. 188923-01-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| L-768242 | L-768242, an indole derivative, has been found to be a CB2 receptor agonist and was once studied to exhibit anti-nociceptive and antihyperalgesic activities in neuropathic and inflammatory pain models. Synonyms: L-768242; L768242; L 768242; GW-405833; GW405833. GW 405833; (2,3-Dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone; (2,3-dichlorophenyl)(5-methoxy-2-methyl-3-(2-morpholinoethyl)-1H-indol-1-yl)methanone; GW405833. Grades: 98%. CAS No. 180002-83-9. Molecular formula: C23H24Cl2N2O3. Mole weight: 483.82. | |
| L-771688 | L-771688, also known as SNAP 6383, is a new potent and highly selective α1A-adrenoceptor antagonist with 500-fold selective over α1B and α1D-adrenoceptors. Synonyms: methyl (4S)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-3-[3-(4-pyridin-2-ylpiperidin-1-yl)propylcarbamoyl]-1,4-dihydropyrimidine; 5-carboxylate; L 771,688; L 771688; L-771,688; L-771688; methyl 4-(3,4-difluorophenyl)-6-((methyloxy)methyl)-2-oxo-3-((((3-(4-2-pyridinyl)-1-piperidinyl)propyl)amino)carbonyl)-1,2,3,4; tetrahydro-5-pyrimidinecarboxylate; SNAP 6383; SNAP-6383. CAS No. 200050-59-5. Molecular formula: C28H33F2N5O5. Mole weight: 557.59. | |
| L-778123 | L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination ofL-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed. Synonyms: L778,123; L-778,123; L 778,123; L 778123; L778123; 1-(3-chlorophenyl)-4-[1-(4-cyanobenzyl)-5-imidazolyl methyl]-2-piperazinone. CAS No. 183499-57-2. Molecular formula: C22H20ClN5O. Mole weight: 405.88. | |
| L-778123 | L-778123 is a dual FPTase and GGPTase-I inhibitor, with IC 50 s of 2 nM and 98 nM respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183499-57-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16273. | |
| L-778123 HCl | L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. Synonyms: 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride; L778123; L-778123; L 778123; L778,123; L-778,123; L 778,123 HCl. Grades: 98%. CAS No. 253863-00-2. Molecular formula: C22H20ClN5O. Mole weight: 405.88. | |
| L-778123 hydrochloride | L-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I , with IC 50 values of 2 nM and 98 nM respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 253863-00-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16273A. | |
| L-779450 | L-779450 is a potent, selective and ATP-competitive Raf kinase inhibitor (IC50 = 10 nM). L-779450 suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf. Synonyms: L-779450; L779450; L 779450; L-779,450; L 779,450; L779,450. Grades: >98%. CAS No. 303727-31-3. Molecular formula: C20H14ClN3O. Mole weight: 347.8. | |
| L-779450 | Raf kinase inhibitor, a potential treatment for neurotraumatic diseases. Its effects also suppress DNA synthesis and induce apoptosis in targeted cells, presenting new applications in treating certain types of cancers. Group: Biochemicals. Alternative Names: 2-Chloro-5-[2-phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol; 4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(4-pyridyl)-1H-imidazole. Grades: Highly Purified. CAS No. 303727-31-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| L-779,450 | L-779,450. Group: Biochemicals. Grades: Purified. CAS No. 303727-31-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| L-783277 | L-783277 is originally isolated from Phoma sp. It inhibits MEK2 with an IC50 of 4 nmol/L. Synonyms: (3S,5Z,8S,9S)-3,4,9,10,11,12-Hexahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione; LL-783277. Grades: ≥95%. CAS No. 791807-02-8. Molecular formula: C19H24O7. Mole weight: 364.39. | |
| L791943 | L791943 is a highly potent and metabolically stable PDE4 inhibitor with good in vitro activity (IC50= 4.2 nM). L-791, 943 is potent in vitro and in vivo as demonstrated by the inhibition of antigen-induced bronchoconstriction in a variety of models.The compound is well absorbed and is well tolerated in the ferret. Synonyms: L791943; L 791943; L-791943; 2-[4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol; L-791,943; L-791943. CAS No. 192767-01-4. Molecular formula: C24H17F10NO4. Mole weight: 573.38. | |
| L-798106 | L-798106 is a potent and selective prostanoid receptor EP3-selective antagonists. L-798106 has been used in multiple studies to tease out EP3 agonist activity, both in vitro and in vivo. L-798106 successfully blocks the actions of sulprostone, an EP3-selective agonist. L-798106 was useful in showing that the vascular contraction effect of PGE2 is due to its prostanoid EP3 agonist activity. Group: Biochemicals. Alternative Names: (2E) -N-[ (5-Bromo-2-methoxyphenyl) sulfonyl]-3-[2- (2-naphthalenylmethyl) phenyl]-2-propenamide; CM 9; GW 671021. Grades: Highly Purified. CAS No. 244101-02-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| L-798,106 | L-798,106. Group: Biochemicals. Grades: Purified. CAS No. 244101-02-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| L-798,106 | L-798,106 is a potent and highly selective prostanoid receptor EP3 antagonist wth Ki value of 0.3 nM. It is used in prostanoid receptor signaling studies that regulates the central excitatory effects of PGE(2) and COX-2 levels on PVN neurons. It has been used to tease out EP3 agonist activity both in vitro and in vivo. It successfully blocks the EP3 agonist activity of sulprostone on guinea pig vas deferens and trachea at 0.2 μM. It attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo. Synonyms: L-798,106; L 798,106; L798,106. N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide; L-798106; (2E)-N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide; CM 9; GW 671021; (E)-N-(5-bromo-2-methoxyphenyl)sulfonyl-3-[2-(naphthalen-2-ylmethyl)phenyl]prop-2-enamide. Grades: ≥99% by HPLC. CAS No. 244101-02-8. Molecular formula: C27H22BrNO4S. Mole weight: 536.44. | |
| L-803,087 trifluoroacetate | L-803,087 trifluoroacetate. Group: Biochemicals. Grades: Purified. CAS No. 217480-26-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| L-803,087 trifluoroacetate | L-803,087 trifluoroacetate is the trifluoroacetate salt of L-803,087, which is a selective and potent somatostatin sst4 receptor agonist often overexpressed in tumours. Its Ki value is 0.7 nM for cloned human sst4. It is a potential therapeutic target. It can be used to study signaling pathways related to somatostatin receptors. It increases kainate-induced seizures in mice in vivo and facilitates AMPA-mediated hippocampal synaptic responses in vitro. Synonyms: L-803,087 trifluoroacetate; L 803,087 trifluoroacetate; L803,087 trifluoroacetate; N2-[4-(5,7-Difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-L-arginine methyl ester trifluoroacetate. Grades: ≥97% by HPLC. CAS No. 217480-26-7. Molecular formula: C27H30F5N5O5. Mole weight: 599.56. | |
| L-817,818 | L-817,818 is a selective and potent somatostatin sst5 receptor agonist with Ki value of 0.4 nM for cloned human sst5 receptors. It inhibits insulin release from mouse pancreatic islets and growth hormone release from rat pituitary cells and in vitro. Synonyms: L-817,818; L 817,818; L817,818. N2-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester; L817818; [(2S)-2-aminopropyl] (2S)-6-amino-2-[[2-(2-naphthalen-2-yl-1H-benzo[g]indol-3-yl)acetyl]amino]hexanoate. Grades: ≥99% by HPLC. CAS No. 217480-27-8. Molecular formula: C33H36N4O3. Mole weight: 536.67. | |
| L-817,818 | L-817,818. Group: Biochemicals. Grades: Purified. CAS No. 217480-27-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| L82 | L82 is a selective and uncompetitive DNA ligase 1 ( DNA Lig1 ) inhibitor (hLig1 IC 50 =12 μM). L82 shows anti-proliferative activity to breast cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 329227-30-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15587. | |
| L-826,266 | L-826,266 is a potent and selective EP3 receptor antagonist. Synonyms: (E)-N-(5-Bromo-2-methoxyphenyl)sulfonyl-3-[5-chloro-2-(naphthalen-2-ylmethyl)phenyl]prop-2-enamide. Grades: ≥98%. CAS No. 244101-03-9. Molecular formula: C27H21BrClNO4S. Mole weight: 570.9. | |
| L-838417 | L-838417. Group: Biochemicals. Alternative Names: 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine. Grades: Highly Purified. CAS No. 286456-42-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C19H19F2N7O. US Biological Life Sciences. | Worldwide |
| L-838,417 | L-838,417 is a subtype-selective GABAA receptor partial agonist. It selectively binds to α2, α3 and α5 subunits with Ki values of 0.67, 0.67 and 2.25 nM respectively, but it shows no efficacy at α1 (α1-sparing). It shows non-sedative antinociceptive, anxiolytic and anti-inflammatory activity in vivo. It was developed by Merck. Uses: Gaba-a receptor agonists. Synonyms: L838417; L 838417; L-838417; 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine; 5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1H-1,2,4-triazole; L-838417. Grades: ≥98% by HPLC. CAS No. 286456-42-6. Molecular formula: C19H19F2N7O. Mole weight: 399.40. | |
| L-838417. (3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine) | A ligand of GABAA receptors. Group: Biochemicals. Alternative Names: 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| L-858,051 hydrochloride | L-858,051 is a water-soluble analog of forskolin that acts as an adenylate cyclase activator. It inhibited the 5-HT-stimulated inositol phosphate (IP) accumulation in canine cultured aorta smooth muscle cells (ASMCs). Synonyms: [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] 4-(4-methylpiperazin-1-yl)butanoate dihydrochloride. Grades: ≥95%. CAS No. 115116-37-5. Molecular formula: C29H50N2O8·2HCl. Mole weight: 609.6. | |
| L-869298 | L-869298 is a high potent and selective PDE4 inhibitor, acts as a Type 4 cyclic nucleotide phosphodiesterase inhibitor. Uses: Type 4 cyclic nucleotide phosphodiesterase inhibitor. Synonyms: L-869298; L-869298; L-869298; (S)-L-869298. 2-Thiazolemethanol, 5-((1S)-1-(3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl)-2-(1-oxido-3-pyridinyl)ethyl)-alpha,alpha-bis(trifluoromethyl)-. Grades: ≥98%. CAS No. 362718-73-8. Molecular formula: C23H18F8N2O4S. Mole weight: 570.45. | |
| L-902,688 | L-902,688 is a highly potent agonist of the human PGE2 receptor subtype EP4. It attenuated right ventricular fibrosis in a monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) rat model. L-902,688 exhibits a neuroprotective effect on ischemic stroke by reducing MMP-3/-9 and BBB damage. Synonyms: (5R)-5-[(E,3R)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl]-1-[6-(2H-tetrazol-5-yl)hexyl]pyrrolidin-2-one. Grades: ≥98%. CAS No. 634193-54-7. Molecular formula: C21H27F2N5O2. Mole weight: 419.5. | |
| L-9-Anthrylalanine | L-9-Anthrylalanine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: D-9-AnthrylaAlanine;D-3-(9-ANTHRYL)ALANINE;D-9-ANTHRYLALANINE. Product Category: Heterocyclic Organic Compound. CAS No. 135092-49-8. Molecular formula: C17H15NO2. Product ID: ACM135092498. Alfa Chemistry ISO 9001:2015 Certified. | |
| LA-1 | LA-1 is an aliphatic unsaturated ketonic acid produced by Streptomyces kitasatoensis NU-4-4-2. It has anti-gram-positive bacteria activity. CAS No. 61947-93-1. Molecular formula: C10H10O3. Mole weight: 178.18. | |
| L-a-Aminoadipic Acid | ≥98%. Group: Biochemicals. Alternative Names: L-2-Aminohexanedioic acid. Grades: Reagent Grade. CAS No. 1118-90-7. Pack Sizes: 1g, 5g. US Biological Life Sciences. | Worldwide |
| L-a-Aminoadipic acid 98+% | L-a-Aminoadipic acid 98+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g, 250g. US Biological Life Sciences. | Worldwide |
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