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| Product | Description | |
|---|---|---|
| H10 | H10 is a potent and cell-active PARP14 inhibitor (IC50 = 490 nM), which exhibits ~ 24- and 18-fold selectivity for PARP14 over PARP1 and TNKS1, respectively. Synonyms: 3-(N-(2-(4-(2-(4-((3-Carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid. Grades: ≥98% by HPLC. CAS No. 2084811-68-5. Molecular formula: C24H27N7O7S. Mole weight: 557.58. |  |
| H 1152 dihydrochloride | H 1152 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 871543-07-6. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| H-1152 Dihydrochloride | H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2. Group: Inhibitors. Alternative Names: 5-[[(2S)-Hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methylisoquinoline. CAS No. 871543-07-6. Molecular formula: C16H23Cl2N3O2S. Mole weight: 392.34. Appearance: White to Off-White Solid. Catalog: ACM871543076. |  |
| H-1152 Dihydrochloride | H-1152 Dihydrochloride is a cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. It inhibits sulprostone-induced contractions in guinea pig aorta (IC50 = 190 nM) and displays proerectile effects in rats. It selectively blocks lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells. Synonyms: (S) - (+) -2-Methyl-1-[ (4-methyl-5-isoquinolynyl) sulfonyl]homopiperazine Dihydrochloride;5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline dihydrochloride;4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline dihydrochloride. Grades: >98 %. CAS No. 871543-07-6. Molecular formula: C16H23Cl2N3O2S. Mole weight: 392.34. | |
| H-1152 Dihydrochloride | H-1152 Dihydrochloride. Group: Biochemicals. Alternative Names: 5-[[(2S)-Hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methylisoquinoline. Grades: Highly Purified. CAS No. 871543-07-6. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C16H23Cl2N3O2S. US Biological Life Sciences. | Worldwide |
| H1152, dihydrochloride (H1152P Dihydrochloride, (S) - (+) -2-Methyl-1- [ (4-methyl-5-isoquinolynyl) sulfonyl] homopiperazine Dihydrochloride) | ROCK Inhibitor. A cell-permeable isoquinolinesulfonamid e compoud that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/. Group: Biochemicals. Alternative Names: H1152P Dihydrochloride, (S) - (+) -2-Methyl-1- [ (4-methyl-5-isoquinolynyl) sulfonyl] homopiperazine Dihydrochloride. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| H-1152Glycyl dihydrochloride | H-1152Glycyl dihydrochloride. Group: Biochemicals. Alternative Names: 2-Amino-1-[ (3S) -hexahydro-3-methyl-4-[ (4-methyl-5-isoquinolinyl) sulfonyl]-1H-1, 4-diazepin-1-yl]ethanone hydrochloride; (2S) -4- (Aminoacetyl) hexahydro-2-methyl-1-[ (4-methyl-5-isoquinolinyl) sulfonyl]-1H-1, 4-diazepine dihydrochloride. Grades: Highly Purified. CAS No. 913844-45-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C18H26Cl2N4O3S. US Biological Life Sciences. | Worldwide |
| H-1152 Glycyl Dihydrochloride | A glycyl analog of Rho-kinase (ROCK) inhibitor that inhibits ROCK with an improved selectitity; for treatment of hypertension and arteriosclerosis. Group: Biochemicals. Alternative Names: 2-Amino-1-[ (3S) -hexahydro-3-methyl-4-[ (4-methyl-5-isoquinolinyl) sulfonyl]-1H-1, 4-diazepin-1-yl]ethanone Hydrochloride; (2S) -4- (Aminoacetyl) hexahydro-2-methyl-1-[ (4-methyl-5-isoquinolinyl) sulfonyl]-1H-1, 4-diazepine Dihydrochloride. Grades: Highly Purified. CAS No. 913844-45-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| H-1,3-cis-ACHC-OMe·HCl | H-1,3-cis-ACHC-OMe·HCl. Group: Biochemicals. Alternative Names: H-1,3-cis-ACHC-OMe·HCl. Grades: Highly Purified. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| H-1,3-cis-ACHC-OMe·HCl 99+% ( | H-1,3-cis-ACHC-OMe·HCl 99+% (. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| H-1,4-cis-ACHC-OMe HCl | Synonyms: cis-4-Amino-cyclohexylcarboxylic acid methyl ester hydrochloride; Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride; 1,4-cis-Aminocyclohexanecarboxylic acid methyl ester hydrochloride; (1S,4S)-Methyl 4-aminocyclohexanecarboxylate hydrochloride. Grades: ≥ 99% (Titration). CAS No. 61367-16-6. Molecular formula: C8H15NO2.HCl. Mole weight: 193.67. | |
| H-1,4-trans-ACHC-OMe HCl | Synonyms: trans-4-Amino-cyclohexylcarboxylic acid methyl ester hydrochloride; (1R,4R)-Methyl 4-aminocyclohexanecarboxylate hydrochloride; Methyl trans-4-aminocyclohexanecarboxylate hydrochloride; methyl 4-aminocyclohexane-1-carboxylate. Grades: ≥ 99% (Titration). CAS No. 61367-07-5. Molecular formula: C8H15NO2.HCl. Mole weight: 193.67. | |
| H-1,4-trans-Achc-OMe·HCl 99+% ( | H-1,4-trans-Achc-OMe·HCl 99+% (. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| H 151 | H 151 is a highly potent, selective STING antagonist, which reduces TBK1 phosphorylation and suppresses human STING palmitoylation. Synonyms: H-151; H151; Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-; N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea; N-(4-Ethylphenyl)-N'-1H-indol-3-ylurea; H 151 (pharmacological agent). Grades: ≥98%. CAS No. 941987-60-6. Molecular formula: C17H17N3O. Mole weight: 279.34. | |
| H-(2)Abz-Acp(6)-Ala-Phe(4-NO2)-Leu-OH | Synonyms: N-[6-[(2-Aminobenzoyl)Amino]Hexanoyl]-L-Ala-4-Nitro-L-Phe-L-Leu-OH. CAS No. 815580-33-7. Molecular formula: C31H42N6O8. Mole weight: 626.70. | |
| H2BBTA | H2BBTA. Group: Nitrogen-containing mof ligand-binary nitrogen-containing mof ligand. Alternative Names: 1,7-Dihydrobenzo[1,2-d:4,5-d']bis([1,2,3]triazole). CAS No. 7221-63-8. Molecular formula: 160.14. Mole weight: C6H4N6. 98%. |  |
| H2DCFDA | H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm) [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate. CAS No. 4091-99-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D0940. |  |
| h2Dnsdc | Renewable & Alternative Energy. Alternative Names: 2,2μ-Dinitro-4,4μ-stilbenedicarboxylic acid;H2DNSDC. CAS No. 1202689-44-8. Catalog: ACM1202689448. | |
| H2-Gamendazole | Gamendazole. CAS No. 877768-84-8. |  Pennsylvania PA |
| H2L5186303 | H2L5186303. Group: Biochemicals. Grades: Purified. CAS No. 139262-76-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| H2L5186303 | H2L5186303 is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 = 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay). Synonyms: H2L5186303; H2L 5186303; H2L-5186303; (Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid. Grades: ≥98% by HPLC. CAS No. 139262-76-3. Molecular formula: C26H20N2O8. Mole weight: 488.45. | |
| H2L 5765834 | H2L 5765834 is an antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 = 94, 463 and 752 nM, respectively). H2L 5765834 may be used for the treatment of systemic sclerosis. Uses: Potential treatment of systemic sclerosis. Synonyms: H2L 5765834; H2L5765834; H2L-5765834; 2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid; 2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxoisoindole-5-carboxylic acid. Grades: ≥99% by HPLC. CAS No. 420841-84-5. Molecular formula: C21H12N2O7. Mole weight: 404.33. | |
| H2L 5765834 | H2L 5765834. Group: Biochemicals. Grades: Purified. CAS No. 420841-84-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| H-2-Me-DL-Ser-OH | . Uses: A serine derivative. used in the synthesis of constrained amino acid buildings blocks and their incorporation into biologically active peptidomimetics. Synonyms: H-DL-aMeSer-OH; alpha-Methyl-DL-serine; DL-2-Methylserine; 2-Methylserine; H-alpha-Me-DL-Ser-OH; H alpha Me DL Ser OH; H 2 Me DL Ser OH. Grades: 95%. CAS No. 5424-29-3. Molecular formula: C4H9NO3. Mole weight: 119.12. | |
| H-2-Me-D-Ser-OH | . Uses: A potential chiral building blocks for the synthesis of different α -methyl α -amino acids. Synonyms: H-D-aMeSer-OH; 2-Methyl-D-serine; H-alpha-Me-D-Ser-OH; H alpha Me D Ser OH; H 2 Me D Ser OH. Grades: 98%. CAS No. 81132-44-7. Molecular formula: C4H9NO3. Mole weight: 119.12. | |
| H-2-Nal-OH HCl | Synonyms: 3-(2-Naphthyl)-L-alanine Hydrochloride; (S)-2-amino-3-(naphthalen-2-yl)propanoic acid hydrochloride. Grades: >98.0%(LC)(T). CAS No. 122745-12-4. Molecular formula: C13H13NO2·HCl. Mole weight: 251.8. | |
| H2N-BCP-CO-OEt HCl | Synonyms: ethyl 3-aminobicyclo[1.1.1]pentane-1-carboxylate hydrochloride. CAS No. 1980049-72-6. Molecular formula: C8H13NO2·HCl. Mole weight: 191.65. | |
| H2N-BCP-COOH HCl | Synonyms: 3-aminobicyclo[1.1.1]pentane-1-carboxylic acid hydrochloride; 3-Aminobicyclo[1.1.1]pentane-1-carboxylic acid hydrochloride; Bicyclo[1.1.1]pentane-1-carboxylic acid,3-amino-,hydrochloride (1:1). Grades: ≥ 95%. CAS No. 1172097-47-0. Molecular formula: C6H9NO2HCl. Mole weight: 163.61. | |
| H2N-BCP-CO-OMe HCl | Synonyms: methyl 3-aminobicyclo[1.1.1]pentane-1-carboxylate hydrochloride; 3-Amino-bicyclo[1.1.1]pentane-1-carboxylic acid methyl ester hydrochloride. CAS No. 676371-65-6. Molecular formula: C7H11NO2·HCl. Mole weight: 177.63. | |
| H2N-PEG24-CH2CH2COOtBu | H2N-PEG24-CH2CH2COOtBu. Group: Polymers. CAS No. 1104076-62-1. Product ID: tert-butyl 3- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- [2- (2-aminoethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] propanoate. Molecular formula: 1202.5g/mol. Mole weight: C55H111NO26. CC (C) (C) OC (= O) CCOCCOCCOCCOCCO CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO CCOCCOCCOCCOCCOCCOCCOCCN. InChI= 1S / C55H111NO26 / c1-55 (2, 3) 82-54 (57) 4-6-58-8-10-60-12-14-62-16-18-64-20-2 2-66-24-26-68-28-30-70-32-34-72-36-38 -74-40-42-76-44-46-78-48-50-80-52-53- 81-51-49-79-47-45-77-43-41-75-39-37-7 3-35-33-71-31-29-69-27-25-67-23-21-65 -19-17-63-15-13-61-11-9-59-7-5-56 / h4-53, 56H2, 1-3H3. LWHDVGRAEHWWFV-UHFFFAOYSA-N. | |
| H2N-PEG2-CH2COOtBu | H2N-PEG2-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1122484-77-8. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-135927. | |
| H2N-PEG2-N3 (TosOH) | CuAAC & SPAAC Click Reactions. Group: Azides. CAS No. 2173092-98-1. Molecular formula: C13H22N4O5S. Mole weight: 346.4. Catalog: CCR2173092981. | |
| H2S Donor 5a | Cysteine-activated hydrogen sulfide (H2S) donor. Regulates the rate of H2S generation. Group: Biochemicals. Grades: Highly Purified. CAS No. 134861-13-5. Pack Sizes: 5mg, 25mg. Molecular Formula: C14H11NO2S. US Biological Life Sciences. | Worldwide |
| H3B-6527 | H3B-6527 is a potent, highly selective and orally active FGFR4 inhibitor with potential antineoplastic activity. Synonyms: N-{2-[ (6-{[ (2, 6-Dichloro-3, 5-dimethoxyphenyl)carbamoyl] (methyl)amino}-4-pyrimidinyl)amino]-5- (4-ethyl-1-piperazinyl)phenyl}acrylamide; H3B-6527; H3B 6527; H3B6527. CAS No. 1702259-66-2. Molecular formula: C29H34Cl2N8O4. Mole weight: 629.543. | |
| H3B-6527 | H3B-6527 is an orally active, highly selective and covalent FGFR4 inhibitor with an IC 50 of <1.2 nM. H3B-6527 has at least 250-fold selectivity over FGFR1-3 with IC 50 s of 320 nM, 1290 nM and 1060 nM respectively. H3B-6527 has potent anti-cancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1702259-66-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100491. | |
| H3B-6545 | H3B-6545 is an oral, selective estrogen receptor covalent antagonist ( SERCA ) for the research of metastatic ER-positive, HER2-negative breast cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2052130-80-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112596. | |
| H3B-6545 hydrochloride | H3B-6545 hydrochloride is an oral, selective estrogen receptor covalent antagonist ( SERCA ) for the research of metastatic ER-positive, HER2-negative breast cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2052132-51-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112596A. | |
| H3B-8800 | H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1825302-42-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111517. | |
| H-4-(7-Hydroxycoumarin-4-yl)-Abu-OH | H-4-(7-Hydroxycoumarin-4-yl)-Abu-OH has been incorporated into proteins as a fluorescent tag. Synonyms: H-(7-Hydroxycoumarin-4-yl)-ethyl-Gly-OH; (S)-2-Amino-4-(7-hydroxy-2-oxo-2H-chromen-4-yl)butanoic acid; L-(7-hydroxycoumarin-4-yl) ethylglycine; umbelliferylethylglycine; (2S)-2-amino-4-(7-hydroxy-2-oxo-2H-1-benzopyran-4-yl)butanoic acid; H-(Umbellifer-4-yl)-ethyl-Gly-OH; 2H-1-Benzopyran-4-butanoic acid, α-amino-7-hydroxy-2-oxo-, (αS)-. Grades: ≥95%. CAS No. 905442-42-4. Molecular formula: C13H13NO5. Mole weight: 263.25. | |
| H-4-Nitro-D-phe-oet · hcl | Heterocyclic Organic Compound. Alternative Names: H-4-NITRO-D-PHE-OET HCL;4-Nitro-D-phenylalanine ethyl ester hydrochloride;H-D-Phe(4-NO2)-OEt.HCl. CAS No. 127641-82-1. Molecular formula: C11H14N2O4·HCl. Mole weight: 274.7. Catalog: ACM127641821. | |
| H4 Receptor antagonist 1 | H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC 50 of 19 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 848217-00-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114025. | |
| H-6-F-Trp-OH | Synonyms: (S)-2-Amino-3-(6-fluoro-1H-indol-3-yl)propanoic acid. CAS No. 19310-00-0. Molecular formula: C11H11FN2O2. Mole weight: 222.2. | |
| H-7 dihydrochloride | H-7 dihydrochloride is a protein kinase inhibitor (IC50 = 6.0, 5.8, 3.0 and 97.0 μM for inhibition of PKC, PKG, PKA and myosin light chain kinase, respectively). H-7 inhibits cell invasion and metastasis in B16BL6 cancer cells through the PKC/MEK/ERK pathway. It was also shown to inhibit Topo I and II in murine L929 cells and induce apoptosis via PKC inhibition. Synonyms: H7 dihydrochloride; H7 HCl. (±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 108930-17-2. Molecular formula: C14H17N3O2S.2HCl. Mole weight: 364.29. | |
| H-7 dihydrochloride | H-7 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 108930-17-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| H-7 Dihydrochloride | Heterocyclic Organic Compound. Alternative Names: H-7 DIHYDROCHLORIDE; 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine Dihydrochloride; H-7 dihydrochloride. CAS No. 108930-17-2. Molecular formula: C14H19Cl2N3O2S. Mole weight: 364.29. Appearance: White Crystalline Solid. Purity: ≥98%. IUPACName: 5-(2-methylpiperazin-1-yl)sulfonylisoquinoline dihydrochloride. Canonical SMILES: CC1CNCCN1S (=O) (=O)C2=CC=CC3=C2C=CN=C3. Cl. Cl. Catalog: ACM108930172. | |
| H 89 | Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM. Synonyms: Protein kinase inhibitor H-89; H89; H 89. Grades: >98%. CAS No. 127243-85-0. Molecular formula: C20H20BrN3O2S. Mole weight: 446.36. | |
| H 89 2HCl | H 89 2HCl is a cell permeable and potent PKA inhibitor with Ki of 48 nM in a cell-free assay, wihich is 10-fold selective for PKA than PKG, 500-fold greater selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. Synonyms: N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥98%. CAS No. 130964-39-5. Molecular formula: C20H20BrN3O2S·2HCl. Mole weight: 519.28. | |
| H 89 dihydrochloride | H 89 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 130964-39-5. Pack Sizes: 1mg, 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| H-89 dihydrochloride (N-5-isoquinolinesulfonamid e . 2HCl) | Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cµ (PKCµ) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H20BrN3O2S. 2HCl, Molecular Weight: 519.3. US Biological Life Sciences. | Worldwide |
| H-89 Dihydrochloride (PKA Inhibitor III, N- [2- ( (p-Bromocinnamyl ) amino) ethyl ]-5-isoquinolinesulfonamid e , 2HCl) | A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48nM). Inhibits other kinases only at much higher concentrations: CaM kinase II (Ki = 29.7uM), casein kinase I (Ki = 38.3uM), myosin light chain kinase (Ki = 28.3uM), protein kinase C (Ki = 31.7uM), and ROCK-II (IC50 = 270nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs) such as GEFI, GEFII, or Epac (exchange protein directly activated by cAMP). Enhances radiation-induced apoptosis in the human cell line BM 13674. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| H-8 dihydrochloride | H-8 is a cell-permeable and potent inhibitor of PKA and PKG with Ki values of 1.2 and 0.48 μM, respectively. It also slightly inhibits PKC and MLCK with Ki values of 15 and 68 μM. Synonyms: N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥98%. CAS No. 113276-94-1. Molecular formula: C12H15N3O2S·2HCl. Mole weight: 338.3. | |
| H-8 dihydrochloride | Potent cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Myosin light chain kinase (MLCK) inhibitor. Tool to study protein crystal structure-inhibitor interactions. Group: Biochemicals. Grades: Highly Purified. CAS No. 113276-94-1. Pack Sizes: 10mg, 50mg. Molecular Formula: C12H15N3O2S 2HCl. US Biological Life Sciences. | Worldwide |
| H-8 dihydrochloride | H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 113276-94-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112465. | |
| H-9 | Heterocyclic Organic Compound. Alternative Names: n- (2-aminoethyl) -5-isoquinolinesulfonamide mono hydrochloride ; n- (2-aminoethyl) -5-isoquinolinesulfonamidmono hydrochloride ; N- (2-AMINOETHYL) -5-ISOQUINOLINESULFONAMide HYDROCHLORIDE;N-(2-AMINOETHYL)ISOQUINOLINE-5-SULFONAMIDE HYDROCHLORIDE;H-9;N-(2-AMINOETHYL)-. CAS No. 116970-50-4. Molecular formula: C11H14ClN3O2S. Mole weight: 287.77. Appearance: Off-White Solid. Catalog: ACM116970504. | |
| H-9 dihydrochloride | H-9 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 116700-36-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| H-9 dihydrochloride | H-9 dihydrochloride is a protein kinase inhibitor. It inhibits PKA (Ki = 1.9 μM), PKG (Ki = 0.9 μM), CaMK II (Ki = 60 μM), PKC (Ki = 18 μM), casein kinase I (Ki = 110 μ M) and casein kinase II (Ki > 300 μM). H-9 hydrochloride reduces the cAMP-mediated excitatory response to serotonin in C. elegans enteric neurons2 and inhibits PKA-mediated phosphorylation in a rat seizure model. Synonyms: H-9 dihydrochloride; H 9 dihydrochloride; H9 dihydrochloride; N-(2-Aminoethyl)-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥99% by HPLC. CAS No. 116700-36-8. Molecular formula: C11H13N3O2S.2HCl. Mole weight: 324.22. | |
| H-9 Dihydrochloride | H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 116700-36-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100923. | |
| H-9 Dihydrochloride | Heterocyclic Organic Compound. Alternative Names: H-9 DIHYDROCHLORIDE;H-9;N-(2-AMINOETHYL)ISOQUINOLINE-5-SULPHONAMIDE DIHYDROCHLORIDE;N-(2-AMINOETHYL)-5-ISOQUINOLINESULFONAMIDE 2HCL;N-(2-AMINOETHYL)-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE;N-(2-aminoethyl)-5-isoquinoline-*sulfonamide hydr. CAS No. 116700-36-8. Molecular formula: C11H15Cl2N3O2S. Mole weight: 324.23. Appearance: White Crystalline Solid. Catalog: ACM116700368. | |
| HA-100 | HA-100 is a potent protein kinase inhibitor, with IC 50 s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG) , cAMP-dependent protein kinase (PKA) , protein kinase C (PKC) and MLC-kinase , respectively. HA-100 also used as a ROCK inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 84468-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100984. | |
| HA-1004 | HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium , that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 91742-10-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-123468. | |
| HA-1004 dihydrochloride | HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein. Synonyms: 5-Isoquinolinesulfonamide, N-[2-[(aminoiminomethyl)amino]ethyl]-, hydrochloride (1:2); 5-Isoquinolinesulfonamide, N-[2-[(aminoiminomethyl)amino]ethyl]-, dihydrochloride; HA 1004 dihydrochloride; HA1004 dihydrochloride; N-(2-guanidinoethyl)-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥98%. CAS No. 92564-08-4. Molecular formula: C12H15N5O2S.2HCl. Mole weight: 366.27. | |
| HA-100 Dihydrochloride | HA-100 Dihydrochloride. Group: Biochemicals. Alternative Names: AGN-PC-00L2ST, SCHEMBL5176161, 1-(5-ISOQUINOLINESULFONYL)-PIPERAZINE. Grades: Highly Purified. CAS No. 210297-47-5. Pack Sizes: 25mg. Molecular Formula: C13 H15 N3O2, Molecular Weight: 350.3. US Biological Life Sciences. | Worldwide |
| HA-1077 dihydrochloride | HA-1077 is a potent and selective inhibitor of Rho kinase (ROCK). HA-1077 exhibited neuroprotective effects and enhanced cognition in mouse models of amyotrophic lateral sclerosis (ALS), suggesting its potential use for cognitive disorders such as ALS, Alzheimer's disease and spinal muscular atrophy. It also suppresses tumor cell motility and metastasis. Synonyms: Fasudil dihydrochloride; 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride. Grades: ≥98%. CAS No. 203911-27-7. Molecular formula: C14H17N3O2S·2HCl. Mole weight: 364.3. | |
| HA1077 (Fasudil Dihydrochloride) | A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK).HA1077 is an inhibitor of ROK/ROCK II (IC50 1.9uM), PRK2 (IC50 4uM), MSK1 (IC50 5uM), Rsk2 (IC50 15uM), PKA, p70 S6 Kinase, CaM Kinase (Ki 1.8nM) and MLCK (Ki 20nM). HA1077 is a calcium antagonist and has antivasospastic properties. Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK. Group: Biochemicals. Alternative Names: Fasudil Dihydrochloride; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine 2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine 2HCl). Grades: Highly Purified. CAS No. 103745-39-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C14H17N3O2S 2HCl, Molecular Weight: 364.29. US Biological Life Sciences. | Worldwide |
| HA 1100 hydrochloride | HA 1100 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 155558-32-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| HA130 | HA130 is a selective autotaxin (ATX) inhibitor with an IC 50 of 28 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1229652-21-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-19329. | |
| HA 130 | HA 130. Group: Biochemicals. Grades: Purified. CAS No. 1229652-21-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| HA-130 | HA-130, an effective autotaxin (ATX) inhibitor, has been found to restrain the cell migration related to ATX in in an A2058 melanoma cells. IC50: 28 nM. Uses: Ha-130 is an effective autotaxin (atx) inhibitor that has been found to restrain the cell migration related to atx in in an a2058 melanoma cells. Synonyms: SCHEMBL1555945; 1229652-21-4; HA130; HA-130; HA 130. Grades: >98 %. CAS No. 1229652-21-4. Molecular formula: C24H19BFNO5S. Mole weight: 463.29. | |
| HA14-1 | HA14-1. Group: Biochemicals. Grades: Purified. CAS No. 65673-63-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| HA14-1 | HA14-1 is a potent Bcl-2 inhibitor with potential anticancer activity. HA14-1 induces apoptosis in various human cancer cells. HA14-1 suppressed NF-kappaB activation through inhibition of phosphorylation and degradation of IkappaBalpha. This inhibition was correlated with suppression of NF-kappaB-dependent gene products (c-myc, cyclin D1, cox-2, and IAP-1). Additionally, HA14-1 also markedly sustained TNF-alpha-mediated JNK activation. Group: Inhibitors. Alternative Names: HA-141, HA 141, HA141. CAS No. 65673-63-4. Molecular formula: C17H17BrN2O5. Mole weight: 409.24. Appearance: Solid powder. Purity: >98%. IUPACName: (R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate. Canonical SMILES: O=C (C1=C (N)OC2=C (C=C (Br)C=C2)[C@H]1[C@H] (C#N)C (OCC)=O)OCC. Catalog: ACM65673634. | |
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