A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
An optically active metabolite of carbamazepine.ee=98% [a]d=-193 (C=1, pyridine). Group: Biochemicals. Alternative Names: R-(-)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, R-MHD, CGP 13698. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
R112
R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(I)] = 96 nmol/L). R112 was able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 and its analogues offer a new modality in the treatment of allergic rhinitis. Synonyms: R112; R 112; R-112. CAS No. 575474-82-7. Molecular formula: C16H13FN4O2. Mole weight: 312.3.
R1128 A is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 A for partially purified rat uterine cytosol receptor was 11 x 10(-7) M. Synonyms: R1128A; R-1128A. CAS No. 135161-96-5. Molecular formula: C17H14O5. Mole weight: 298.29.
R1128 B
R1128 B is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 B for partially purified rat uterine cytosol receptor was 1.2 x 10(-7) M. Synonyms: R1128B; R-1128B. CAS No. 135161-97-6. Molecular formula: C18H16O5. Mole weight: 312.3.
R1128 C
R1128 C is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 C for partially purified rat uterine cytosol receptor was 2.6 x 10(-7) M. Synonyms: R1128C; R-1128C. CAS No. 135161-98-7. Molecular formula: C19H18O5. Mole weight: 326.3.
R1128 D
R1128 D is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 D for partially purified rat uterine cytosol receptor was 2.7 x 10(-7) M. Synonyms: R1128D; R-1128D. CAS No. 135161-99-8. Molecular formula: C19H18O5. Mole weight: 326.3.
R)-(+)-1,1'-Bi-2-naphthol
5g Pack Size. Group: Building Blocks, Chiral Compounds, Ligands. Formula: C20H14O2. CAS No. 18531-94-7. Prepack ID 47008781-5g. Molecular Weight 286.32. See USA prepack pricing.
R)-(+)-1,1'-Bi-2-naphthol
25g Pack Size. Group: Building Blocks, Chiral Compounds, Ligands. Formula: C20H14O2. CAS No. 18531-94-7. Prepack ID 47008781-25g. Molecular Weight 286.32. See USA prepack pricing.
R-121919
R-121919 is a potent orally active small-molecule Corticotropin-Releasing factor 1 (CRF1) receptor antagonist for the treatment of anxiety and depression, while having little affinity at the CRF2 receptor subtype. Synonyms: R121919; R-121919; R 121919; R121,919; R-121,919; R 121,919; NBI30775; NBI 30775; NBI-30775;3-(6-(DIMETHYLAMINO)-4-METHYLPYRIDIN-3-YL)-2,5-DIMETHYL-N,N-DIPROPYLPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE; 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine. Grades: >98%. CAS No. 195055-03-9. Molecular formula: C22H32N6. Mole weight: 380.53.
R 121919 hydrochloride
R 121919 hydrochloride is a potent and orally available corticotropin releasing factor receptor1 (CRF1) antagonist. Synonyms: 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine hydrochloride. Grades: ≥98% by HPLC. CAS No. 195055-66-4. Molecular formula: C22H32N6·HCl. Mole weight: 416.99.
R)-1,2,4-Butanetriol
100mg Pack Size. Group: Building Blocks, Chiral Compounds, Organics. Formula: HOCH2CH2CH(OH)CH2OH. CAS No. 70005-88-8. Prepack ID 70324555-100mg. Molecular Weight 106.12. See USA prepack pricing.
R-(-)-1,2-Propanediol
1g Pack Size. Group: Aroma Chemicals, Building Blocks, Chiral Compounds, Flavours and Fragrance Materials, Solvents. Formula: C3H8O2. CAS No. 4254-14-2. Prepack ID 26046346-1g. Molecular Weight 76.09. See USA prepack pricing.
R-(-)-1,2-Propanediol
R-(-)-1,2-Propanediol. Group: Biochemicals. Alternative Names: (-)-1,2-Propanediol; (-)-Propylene Glycol; (2R)-1,2-Propanediol; (R)-1,2-Propanediol; (R)-2-Hydroxy-1-propanol; (R)-Propylene Gycol; 1-Deoxy-sn-glycerol; D-(-)-Propanediol; NSC 90793. Grades: Highly Purified. CAS No. 4254-14-2. Pack Sizes: 10g. Molecular Formula: C3H8O2, Molecular Weight: 76.09. US Biological Life Sciences.
Worldwide
R)-(+)-1,2-Propylene carbonate
1g Pack Size. Group: Building Blocks, Chiral Compounds, Organics. Formula: C4H6O3. CAS No. 16606-55-6. Prepack ID 24382572-1g. Molecular Weight 102.09. See USA prepack pricing.
R-130823
R-130823 is a highly selective inhibitor against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823, with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively. Synonyms: R130823; R 130823; 2-(4-Fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole. CAS No. 321344-32-5. Molecular formula: C28H26FN3. Mole weight: 423.53.
R13/3 Manganese-ore concentrate
R13/3 Manganese-ore concentrate. Uses: For analytical and research use. Group: Process materials, geological, cement & soils. Catalog: APS011615. Shipping: Room Temperature.
R-1479
R1479 is a potent and highly specific inhibitor of HCV replication in cell culture, and that its triphosphate is a potent and highly selective inhibitor of NS5B mediated RNA synthesis, the HCV encoded RNA polymerase. Synonyms: 4'-alpha-Azido-cytidine; Balpiravir; 4'-Azidocytidine; R1479; R 1479; 4-amino-1-((2R,3R,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one. Grades: ≥95%. CAS No. 478182-28-4. Molecular formula: C9H12N6O5. Mole weight: 284.23.
R 1485 dihydrochloride
R 1485 dihydrochloride is a selective and high affinity 5-HT6 antagonist (pKi = 8.9), with >100 fold selectivity against a panel of 50 targets including other 5-HT receptor subtypes. Synonyms: R 1485 dihydrochloride; R1485 dihydrochloride; R-1485 dihydrochloride; 4-[(2-Fluorophenyl)sulfonyl]-3,4-dihydro-8-(1-piperazinyl)-2H-1,4-benzoxazine dihydrochloride; R 1485.2HCl. Grades: ≥98% by HPLC. Molecular formula: C18H20FN3O3S.2HCl. Mole weight: 450.35.
R 1485 dihydrochloride
R 1485 dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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R1487 HCl
R1487 is an orally bioavailable and highly selective inhibitor of p38α mitogen-activated protein kinase, with Kd values of 0.2 nM and 29 nM for p38α and p38β, respectively. Synonyms: R1487 ; R 1487 ; R-1487 ; R1487 HCl. Grades: 98%. CAS No. 449808-64-4. Molecular formula: C19H19ClF2N4O3. Mole weight: 424.83.
R1530
R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta, FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis. Synonyms: R-1530; R 1530. Grades: >98%. CAS No. 882531-87-5. Molecular formula: C18H14ClFN4O. Mole weight: 356.78136.
R 1530
R 1530. Group: Biochemicals. Grades: Purified. CAS No. 882531-87-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
R162
R162 is a potent, selective inhibitor of glutamate dehydrogenase 1 (GDH1) (Ki = 28.6 μM), with anti-cancer properties. It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. Synonyms: R 162; R-162; 2-allyl-1-hydroxy-anthraquinone; 2-allyl-1-hydroxyanthra-9,10-quinone. CAS No. 64302-87-0. Molecular formula: C17H12O3. Mole weight: 264.28.
R176502
R176502 is a bafilolide metabolite with potent antiproliferative activity, which is produced by Micromonospora sp. JS1035. It inhibits proliferation of MCF-7, HT-29, K562/C1000 and Malme-3M cells with IC50 values of 1.29 ± 0.35, 0.61 ± 0.04, 9.29 ± 7.35, 7.96 ± 2.75 nmol/L. Synonyms: R 176502. Molecular formula: C47H67NO13. Mole weight: 854.
R18
R18. Group: Biochemicals. Grades: Purified. CAS No. 211364-78-2. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
R18
R18, a competitive inhibitor of 14-3-3 scaffolding proteins (KD ?80 nM), blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. Synonyms: R18; R 18; R-18; L-Prolyl-L-histidyl-L-cysteinyl-L-valyl-L-prolyl-L-arginyl-L-a-aspartyl-L-leucyl-L-seryl-L-tryptophyl-L-leucyl-L-a-aspartyl-L-leucyl-L-a-glutamyl-L-alanyl-L-asparaginyl-L-methionyl-L-cysteinyl-L-leucyl-L-proline trifluoroacetate; PHCVPRDLSWLDLEANMCLP trifluoroacetate; Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro trifluoroacetate. Grades: >98%. CAS No. 211364-78-2. Molecular formula: C101H157N27O29S3. Mole weight: 2309.69.
R-191
R-191 is an IRAK-4 inhibitor that has the potential to treat hematological malignancy. Studies showed that it inhibited the production of cytokines induced by TLR and IL-1R in primary cells, as well as the expression of programmed death ligand-1 (PD-L1) in acute myeloid leukemia cell lines. Uses: The treatment of hematological malignancy. Synonyms: R-191; R 191; R191.
R-(-)-1-Indanol
R-(-)-1-Indanol. Group: Biochemicals. Grades: Highly Purified. CAS No. 697-64-3. Pack Sizes: 250mg, 500mg, 1g. US Biological Life Sciences.
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R-1 methanandamide
R-1 methanandamide is a potent cannabinoid (CB) receptor 1 agonist with selectivity for CB1 over CB2 receptors with Ki values ranging from 17.9 to 28.3 and 815 to 868 nM, respectively. Synonyms: (R)-methanandamide; R(+)-Methanandamide; R-(+)-methanandamide; AM-356; AM 356; AM356; (R)-(+)-Arachidonyl-1'-Hydroxy-2'-Propylamide. Grades: ≥98%. CAS No. 157182-49-5. Molecular formula: C23H39NO2. Mole weight: 361.6.
5g Pack Size. Group: Building Blocks, Chiral Compounds, Organics. Formula: C6H10O3. CAS No. 15186-48-8. Prepack ID 64747409-5g. Molecular Weight 130.14. See USA prepack pricing.
R243
R243 is an inhibitor of CCR8 signaling and chemotaxis. Group: Inhibitors. Alternative Names: R243; R-243; R 243. CAS No. 688352-84-3. Molecular formula: C21H27NO4. Mole weight: 357.45. Appearance: Solid powder. Purity: >98%. IUPACName: 7,8-Dihydro-7-[2-(tricyclo[3.3.1.1(3,7)]dec-1-yloxy)ethyl]-6H-1,3-dioxolo[4,5-g][1,3]benzoxazine. Canonical SMILES: N1 (CCOC2 (C3)CC4CC3CC (C4)C2)COC5=CC (OCO6)=C6C=C5C1. Catalog: ACM688352843.
R 268712
R 268712. Group: Biochemicals. Grades: Purified. CAS No. 879487-87-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
R-268712
R-268712 is a potent and selective inhibitor of TGF-β type I receptor/ALK5 with an IC50 of 2.5 nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK). It suppresses development of renal fibrosis in a unilateral ureteral obstruction model. It also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model. Synonyms: R-268712; R 268712; R268712. Grades: >98 %. CAS No. 879487-87-3. Molecular formula: C20H18FN5O. Mole weight: 363.39.
R-(-)-2-Amino-1-butanol
5g Pack Size. Group: Building Blocks, Chiral Compounds, Organics. Formula: C4H11NO. CAS No. 5856-63-3. Prepack ID 24885258-5g. Molecular Weight 89.14. See USA prepack pricing.
R-2-(Aminomethyl)-1-BOC-pyrrolidine hydrochloride
R-2-(Aminomethyl)-1-BOC-pyrrolidine hydrochloride. Group: Biochemicals. Alternative Names: (R)-tert-Butyl 2- (aminomethyl) pyrrolidine-1-carboxylate hydrochloride. Grades: Highly Purified. CAS No. 1190890-12-0. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C10H20N2O2·HCl. US Biological Life Sciences.
1g Pack Size. Group: Building Blocks, Chiral Compounds, Organics. Formula: C4H10O. CAS No. 14898-79-4. Prepack ID 61686152-1g. Molecular Weight 74.12. See USA prepack pricing.
R(+)-2-Chloropropionic acid 98+%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 7474-5-7. Pack Sizes: 1g, 5g, 25g, 100g, 250g. US Biological Life Sciences.
Worldwide
R)-(-)-2-Octanol
1g Pack Size. Group: Aroma Chemicals, Building Blocks, Flavours and Fragrance Materials. Formula: CH3(CH2)5CH(OH)CH3. CAS No. 5978-70-1. Prepack ID 17478884-1g. Molecular Weight 130.23. See USA prepack pricing.
R)-(-)-2-Phenylglycine
100g Pack Size. Group: Amino Acids, Biochemicals, Chiral Compounds. Formula: C8H9NO2. CAS No. 875-74-1. Prepack ID 35200423-100g. Molecular Weight 151.16. See USA prepack pricing.
R)-(-)-2-Phenylglycinol
5g Pack Size. Group: Amines, Building Blocks, Chiral Compounds. Formula: C8H11NO. CAS No. 56613-80-0. Prepack ID 90029563-5g. Molecular Weight 137.18. See USA prepack pricing.
R-30490 is a Fentanyl (F274990) analog. Fentanyl is used as an analgesic. Group: Biochemicals. Grades: Highly Purified. CAS No. 60618-49-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H32N2O2, Molecular Weight: 380.52. US Biological Life Sciences.
Worldwide
R306465
R306465, also known as JNJ-16241199, is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro. R306465 potently inhibited cell proliferation of all main solid tumour indications, including ovarian, lung, colon, breast and prostate cancer cell lines, with IC50 values ranging from 30 to 300 nM. The high activity of R306465 in cell-based assays and in vivo after oral administration makes R306465 a promising novel antitumoral agent with potential applicability in a broad spectrum of human malignancies. Uses: Histone deacetylase inhibitors. Synonyms: R 306465; R-306465; JNJ-16241199; JNJ16241199; JNJ 16241199. CAS No. 604769-01-9. Molecular formula: C19H19N5O4S. Mole weight: 413.45.
R-3,3,3-Trifluoro-2-hydroxypropionic acid
R-3,3,3-Trifluoro-2-hydroxypropionic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 121250-04-2. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences.
Worldwide
R-3930
R-3930. Group: Polymers.
R-(3)-Benzyloxy myristic acid
R-(3)-Benzyloxy myristic acid. Group: Biochemicals. Alternative Names: (R)-3-Benzyloxytetradecanoic acid; (3R) -3- (Phenylmethoxy) tetradecanoic acid. Grades: Highly Purified. CAS No. 87357-67-3. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C21H34O3. US Biological Life Sciences.
Worldwide
R-(3)-Benzyloxy myristic acid methyl ester
R-(3)-Benzyloxy myristic acid methyl ester. Group: Biochemicals. Alternative Names: (R)-3-Benzyloxytetradecanoic acid methyl ester; (3R) -3- (Phenylmethoxy) tetradecanoic acid methyl ester. Grades: Highly Purified. CAS No. 114264-01-6. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C22H36O3. US Biological Life Sciences.
R-3- (N-Benzyl oxycarbonyl pyrrolidin-2-yl carbonyl ) -5-bromo-1H-indole. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
R-(-)-3-Quinuclidinol
R-(-)-3-Quinuclidinol. Group: Biochemicals. Alternative Names: (R)-(-)-3-Hydroxyquinuclidine; (R)-(-)-1-Azabicyclo[2.2.2]octan-3-ol. Grades: Highly Purified. CAS No. 25333-42-0. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C7H13NO. US Biological Life Sciences.
Worldwide
R-(-)-3-Quinuclininol HCl
R-(-)-3-Quinuclininol HCl. Group: Biochemicals. Grades: Highly Purified. CAS No. 42437-96-7. Pack Sizes: 1g, 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
R406
R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling (EC(50) for degranulation=56-64 nM). The primary target for R406 is the spleen tyrosine kinase (Syk). R406 inhibited phosphorylation of Syk substrate linker for activation of T cells in mast cells and B-cell linker protein/SLP65 in B cells. R406 bound to the ATP binding pocket of Syk and inhibited its kinase activity as an ATP-competitive inhibitor (K(I)=30 nM). Furthermore, R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 is orally bioavailable, achieving exposures capable of inhibiting Syk-dependent IgE-mediated basophil activation. Collectively, the results show R406 potential for modulating Syk activity in human disease. Synonyms: R 406; R-406. CAS No. 841290-80-0. Molecular formula: C22H23FN6O5. Mole weight: 470.45.
R406 Benzenesulfonate
R406 is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Synonyms: R406; R 406; R-406. Grades: >98%. CAS No. 841290-81-1. Molecular formula: C28H29FN6O8S. Mole weight: 628.63.
R-4200
R-4200. Group: Polymers.
R 428 dihydrochloride
R 428 dihydrochloride is a potent and selective inhibitor of Axl receptor tyrosine kinases (IC50 = 14 nM). R428 inhibits Axl kinase and Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Synonyms: R 428 dihydrochloride; R428 dihydrochloride; R-428 dihydrochloride; 1-(6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine dihydrochloride; Thiocolchicoside dihydrochloride. Grades: 99%. CAS No. 2108833-51-6. Molecular formula: C30H34N8.2HCl. Mole weight: 579.57.
R)-(+)-4-Benzyl-2-oxazolidinone
5g Pack Size. Group: Amino Acids, Building Blocks, Organics. Formula: C10H11NO2. CAS No. 102029-44-7. Prepack ID 27204332-5g. Molecular Weight 177.2. See USA prepack pricing.
R)-4-Benzylthiazolidine-2-thione
1g Pack Size. Group: Building Blocks, Organics. Formula: C10H11NS2. CAS No. 110199-17-2. Prepack ID 90028106-1g. Molecular Weight 209.33. See USA prepack pricing.
r-(+)-4-Phenyl-1,3-dioxane
Heterocyclic Organic Compound. Alternative Names: R-(+)-4-PHENYL-1,3-DIOXANE;(R)-(+)-4-PHENYL-1 3-DIOXANE 99%. CAS No. 107796-29-2. Molecular formula: C10H12O2. Mole weight: 164.20108. Density: 1.111 g/mL at 25 °C(lit.). Catalog: ACM107796292.