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| Product | Description | |
|---|---|---|
| R-Naproxen | A metabolite of Naproxen, which is a non-selective COX inhibitor. Synonyms: (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid; (R)-(-)-6-Methoxy-α-methyl-2-naphthaleneacetic acid. Grades: > 95%. CAS No. 23979-41-1. Molecular formula: C14H14O3. Mole weight: 230.27. |  |
| RNase A, Bovine pancreas | RNase A, Bovine pancreas (Ribonuclease A) cleaves the 3' end of RNA to pyrimidine and actively cleaves RNA at each pyrimidine residue. RNase A, bovine pancreas catalyzes the hydrolysis of single-stranded RNA in the absence of metal ions or cofactors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ribonuclease A; EC 4.6.1.18; RNase A. CAS No. 9001-99-4. Pack Sizes: 25 mg; 50 mg. Product ID: HY-129046. |  |
| RNase H | RNase H. Ribonuclease h (rnase h) specifically degrades the rna strand in rna-dna hybrids. it does not hydrolyze the phosphodiester bonds within single-stranded and double-stranded dna and rna. this product is purified from e. coli expressing the recombinant rnha gene on a plasmid with 17 kda molecular weight and it can be inactivated by heating at 65°c for 20 minutes. Group: DNA Modifying Enzymes. Purity: 100U; 5*100KU. Storage: Store at -20°C. Cat No: ME-4003. |  |
| RNA uridylyltransferase | The enzyme requires an oligoribonucleotide or polyribonucleotide with a free terminal 3'-OH as a primer. Group: Enzymes. Synonyms: terminal uridylyltransferase; TUT. Enzyme Commission Number: EC 2.7.7.52. CAS No. 78519-53-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3265; RNA uridylyltransferase; EC 2.7.7.52; 78519-53-6; terminal uridylyltransferase; TUT. Cat No: EXWM-3265. | |
| R)-(+)-N-Benzyl-1-phenylethylamine | R)-(+)-N-Benzyl-1-phenylethylamine. Group: Biochemicals. Alternative Names: (α R) -α -Methyl-N- (phenylmethyl) benzenemethanamine; (+)-Benzylphenethylamine; (+)-N-Benzyl-1-phenylethylamine; (+)-N-Benzyl-α-phenylethylamine; (R)-(+)-N-Benzyl-α-methylbenzylamine; (R)-Benzyl(α-methylbenzyl)amine; (R)-N-(α-Methylbenzyl)-N-benzylamine; (R)-N-Benzyl-1-phenyl-1-ethylamine; (R)-N-Benzyl-1-phenylethanamine; (R)-N-Benzyl-1-phenylethylamine; (R)-N-Benzyl-N-α-methylbenzylamine; (R)-N-Benzyl-α-methylbenzylamine; (R)-N-Benzyl-α-methylbenzylamine; Benzyl((R)-1-phenylethyl)amine; N-Benzyl((R)-1-phenylethyl)amine; N-Benzyl-(R)-α-methylbenzylamine; N- [ (R) -1-Phenylethyl] benzylamine. Grades: Highly Purified. CAS No. 38235-77-7. Pack Sizes: 1g. Molecular Formula: C15H17N, Molecular Weight: 211.3. US Biological Life Sciences. |  Worldwide |
| R-(-)-N-Demethyl Deprenyl | A metabolite of selegiline. Selegiline, also known as L-deprenyl, is a substituted phenethylamine. At normal clinical doses, it is a selective irreversible MAO-B inhibitor used to reduce symptoms in early-stage Parkinson's disease. In larger doses it loses its specificity and also inhibits MAO-A. Uses: Monoamine oxidase inhibitors. Synonyms: (αR)-α-Methyl-N-2-propyn-1-yl-benzeneethanamine; (-)-Desmethylselegiline; (-)-N-Desmethylselegiline; Desmethylselegiline; L-Desmethyldeprenyl; L-Nordeprenyl; N-Desmethylselegiline; Norselegiline. Grades: > 95%. CAS No. 56862-28-3. Molecular formula: C12H15N. Mole weight: 173.25. | |
| R-(-)-N-Desmethyl mephenytoin | R-(-)-N-Desmethyl mephenytoin. Group: Biochemicals. Alternative Names: R-(-)-Nirvanol, R-(-)-5-ethyl-5-phenylhydantoin. Grades: Highly Purified. CAS No. 65567-32-01. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C11H12N2O2. US Biological Life Sciences. | Worldwide |
| R-(-)-N-Desmethylmephenytoin (R-(-)-Nirvanol, R-(-)-5-Ethyl-5-phenylhydantoin) | An anticonvulsant, hypnotic. A metabolite of Mephentoin. Group: Biochemicals. Alternative Names: R-(-)-Nirvanol, R-(-)-5-Ethyl-5-phenylhydantoin. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| R(-)-N-Ethylnorapomorphine hydrochloride | R(-)-N-Ethylnorapomorphine hydrochloride is a dopamine D2 receptor agonist. Synonyms: (6aR)-6-ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrobromide. Grades: 99%. CAS No. 123240-93-7. Molecular formula: C18H19NO2.HBr. Mole weight: 362.26. | |
| r-(+)-N,N'-Dimethyl-7,7'-bis(di(3,5-xylyl)phosphino)-3,3',4,4'-tetrahydro-8,8'-bi-2H-1,4-benzoxazine isopropanol adduct | r-(+)-N,N'-Dimethyl-7,7'-bis(di(3,5-xylyl)phosphino)-3,3',4,4'-tetrahydro-8,8'-bi-2H-1,4-benzoxazine isopropanol adduct. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Xylyl-Solphos SL-A002-2, AGN-PC-00IRC6, 40654_ALDRICH, (R)-7,7 inverted exclamation marka-Bis[bis(3,5-dimethylphenyl)phosphino]-3,3 inverted exclamation marka,4,4 inverted exclamation marka-tetrahydro-4,4 inverted exclamation marka-dimethyl-8,8 inverted exclamation marka-bi(2H-1,4-benzoxazine), (R)-7,7 inverted exclamation marka-Bis[di(3,5-xylyl)phosphino]-3,3 inverted exclamation marka,4,4 invert. Product Category: Heterocyclic Organic Compound. CAS No. 649559-70-6. Molecular formula: C53H62N2O3P2. Mole weight: 837.02. Purity: 0.96. IUPACName: [8-[7-bis(3,5-dimethylphenyl)phosphanyl-4-methyl-2,3-dihydro-1,4-benzoxazin-8-yl]-4-methyl-2,3-dihydro-1,4-benzoxazin-7-yl]-bis(3,5-dimethylphenyl)phosphane. Canonical SMILES: CC1=CC(=CC(=C1)P(C2=C(C3=C(C=C2)N(CCO3)C)C4=C(C=CC5=C4OCCN5C)P(C6=CC(=CC(=C6)C)C)C7=CC(=CC(=C7)C)C)C8=CC(=CC(=C8)C)C)C.CC(C)O. Product ID: ACM649559706. Alfa Chemistry ISO 9001:2015 Certified. |  |
| R(-)-Norapomorphine hydrobromide | R(-)-Norapomorphine hydrobromide is a potent dopamine receptor agonist. Synonyms: (R)-5,6,6a,7-Tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrobromide. Grades: 98%. CAS No. 115017-61-3. Molecular formula: C16H15NO2.HBr. Mole weight: 334.21. | |
| R-(-)-Norapomorphine hydrochloride | R-(-)-Norapomorphine hydrochloride. Group: Biochemicals. Alternative Names: (6aR)-5,6,6a,7-Tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride; 6a-b-Noraporphine-10,11-diol hydrochloride; (-)-Norapomorphine hydrochloride. Grades: Highly Purified. CAS No. 420382-69-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C16H16ClNO2. US Biological Life Sciences. | Worldwide |
| RNPA1000 | RNPA1000 isa RnpA inhibitor as an attractive antimicrobial development candidate. Uses: Rnpa inhibitor. Synonyms: RNPA1000; RNPA-1000; RNPA 1000; 4-[3-[(E)-3-(3-bromoanilino)-2-cyano-3-oxoprop-1-enyl]-2,5-dimethylpyrrol-1-yl]benzoic acid. Grades: ≥98%. CAS No. 359600-10-5. Molecular formula: C23H18BrN3O3. Mole weight: 464.3. | |
| RNPA1000 | RNPA1000, an antibiotic , is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC 50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 359600-10-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-12824. | |
| R(-)-N-Propylnorapomorphine hydrobromide | A potent and selective dopamine D2 receptor agonist. Grades: 99%. CAS No. 85199-01-5. Molecular formula: C19H21NO2.HBr. Mole weight: 376.29. | |
| Ro 01-6128 | Ro 01-6128 is a positive allosteric modulator of mGluR1 that potentiates glutamate-induced calcium release (EC50 = 104 nM). Ro 01-6128 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate with an EC50 value of 248 nM and potentiates glutamate-induced cAMP production with an EC50 value of 21.5 μM. Synonyms: (Diphenylacetyl)-carbamic acid ethy ester; Ro01-6128; Ro-01-6128; Ro 01-6128. Grades: ≥98% by HPLC. CAS No. 302841-86-7. Molecular formula: C17H17NO3. Mole weight: 283.32. | |
| Ro 01-6128 | Ro 01-6128. Group: Biochemicals. Grades: Purified. CAS No. 302841-86-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| RO-0335 | RO-0335 is a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Two pathways to loss of susceptibility to RO-0335 were observed, containing patterns of amino acid changes at either V106I/A plus F227C (with additional contributions from A98G, V108I, E138K, M230L and P236L) or V106I/Y188L (with a potential contribution from L100I, E138K and Y181C). Characterization of the observed mutations by site-directed mutagenesis in the isogenic HXB2D background demonstrated that a minimum of two or more mutations were required for significant loss of susceptibility, with the exception of Y188L, which requires a two-nucleotide change. Patterns containing F227C or quadruple mutations selected by RO-0335 showed a low relative fitness value when compared to wild-type HXB2D. Uses: Designed for use in research and industrial production. Additional or Alternative Names: RO0335; RO-0335; RO 0335. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 867365-76-2. Molecular formula: C21H13BrCl2FN3O4S. Mole weight: 573.22. Purity: >98%. IUPACName: 2-(4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl)-N-(2-chloro-4-sulfamoylphenyl)acetamide. Canonical SMILES: O=C(NC1=CC=C(S(=O)(N)=O)C=C1Cl)CC2=CC=C(Br)C(OC3=CC(C#N)=CC(Cl)=C3)=C2F. Product ID: ACM867365762. Alfa Chemistry ISO 9001:2015 Certified. | |
| RO-0335 | RO-0335 is a novel diphenylether nonnucleoside reverse transcriptase inhibitor. RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates. Synonyms: RO0335; RO 0335; N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoroBenzeneacetamide. Grades: 99%. CAS No. 867365-76-2. Molecular formula: C21H13BrCl2FN3O4S. Mole weight: 573.21. | |
| Ro 0437626 | Ro 0437626. Group: Biochemicals. Grades: Purified. CAS No. 134362-79-1. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. | Worldwide |
| Ro 0437626 | Ro 0437626, a benzimidazole-2-carboxamide derivative, is a selective P2X1 purinergic receptor antagonist (IC50 = 3 μM) with >30-fold selectivity over the P2X 2 , P2X 3 and P2X 2/3 receptors. Synonyms: N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide; RO1166446/008; RO116 6446/008; RO116-6446/008; RO116-6446008; RO-0437626; RO 0437626; RO0437626. Grades: ≥98% by HPLC. CAS No. 134362-79-1. Molecular formula: C27H35N5O4S. Mole weight: 525.66. | |
| Ro 04-5595 | Ro 04-5595 hydrochloride is a selective NMDA receptor inhibitor (Ki = 31 nM). Synonyms: 1-[2-(4-Chlorophenyl)ethyl]-1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinol hydrochloride. Grades: ≥98% by HPLC. CAS No. 64047-73-0. Molecular formula: C19H22ClNO2.HCl. Mole weight: 368.3. | |
| Ro 04-5595 hydrochloride | Ro 04-5595 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 64047-73-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 04-6790 | Ro 04-6790. Group: Biochemicals. Grades: Purified. CAS No. 202466-68-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 04-6790 | Ro 04-6790 is a potent and selective 5-HT6 receptor antagonist (pKi= 7.26 and 7.35 at rat and human 5-HT6 receptors respectively). Some studies indicate that Ro 04-6790 attenuates behavioural effects related to the hypofunction of the NMDA receptor suggesting that this compound might be involved in the psychotomimetic effects of non-competitive NMDA receptor antagonists. Synonyms: Ro 04-6790; Ro04-6790; Ro-04-6790. 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide; Ro 04-6790; Ro04-6790; Ro-04-6790. Grades: ≥98% by HPLC. CAS No. 202466-68-0. Molecular formula: C12H16N6O2S. Mole weight: 308.36. | |
| RO 04-6790 hydrochloride | RO 04-6790 hydrochloride is a potent and selective serotonin 5-HT6 receptor antagonist. Synonyms: RO 04-6790 hydrochloride; RO-04-6790 hydrochloride; RO046790 hydrochloride; RO 046790 hydrochloride; 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide Dihydrobromide. Grades: 98%. CAS No. 1197333-95-1. Molecular formula: C12H16N6O2S.2HCl. Mole weight: 381.28. | |
| Ro 08-2750 | Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM). NGF has potential effects on matrix turnover activity and influences the catabolic/anabolic balance of IVD cells in an adverse way that may potentiate IVD degeneration. Anti-NGF treatment might be beneficial to ameliorate progressive tissue breakdown in IVD degeneration and may lead to pain relief. Synonyms: Ro08-2750; Ro-08-2750; Ro 082750; Ro-82750; Ro082750; 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde. Grades: 98%. CAS No. 37854-59-4. Molecular formula: C13H10N4O3. Mole weight: 270.25. | |
| Ro 08-2750 | Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM). NGF has potential effects on matrix turnover activity and influences the catabolic/anabolic balance of IVD cells in an adverse way that may potentiate IVD degeneration. Anti-NGF treatment might be beneficial to ameliorate progressive tissue breakdown in IVD degeneration and may lead to pain relief. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ro 08-2750; Ro08-2750; Ro-08-2750; Ro 082750; Ro -082750; Ro082750. Product Category: Inhibitors. Appearance: Orange to red solid powder. CAS No. 37854-59-4. Molecular formula: C13H10N4O3. Mole weight: 270.25. Purity: >95%. IUPACName: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde. Canonical SMILES: O=CC1=C(C)C=C2N=C3C(NC(N=C3N(C)C2=C1)=O)=O. Product ID: ACM37854594. Alfa Chemistry ISO 9001:2015 Certified. | |
| Ro 08-2750 | Ro 08-2750. Group: Biochemicals. Grades: Purified. CAS No. 37854-59-4. Pack Sizes: 1mg, 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 09-1679 | Ro 09-1679 is a thrombin inhibitor produced by Mortierella alpina NR6773. It inhibits thrombin, Factor Xa, trypsin and papain with IC50 values of 33.6, 3.3, 0.04 and 0.0346 μmol/L. Synonyms: L-Leucinamide, N2-(3-carboxy-1-oxo-2-propenyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, (S-(E))-. CAS No. 141426-89-3. Molecular formula: C22H39N9O6. Mole weight: 525.61. | |
| RO10-5824 | RO10-5824 is a D4-selective partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM), and is approximately 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors. RO10-5824 is a potent candidate for the management of cocaine use disorders. Synonyms: 2-methyl-5-((4-phenyl-5,6-dihydropyridin-1(2H)-yl)methyl)pyrimidin-4-amine; RO10-5824; RO 10-5824; RO-10-5824; RO105824; RO 105824; RO-105824. CAS No. 189744-46-5. Molecular formula: C17H20N4. Mole weight: 280.37. | |
| Ro 10-5824 dihydrochloride | Ro 10-5824, a D4R partial agonist, might have beneficial effects on attention and impulsivity by modulating baseline gamma activity in the frontal cortex. Synonyms: Ro 10-5824 dihydrochloride; Ro10-5824 dihydrochloride; Ro-10-5824 dihydrochloride; 2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine;dihydrochloride; Ro 10-5824 (dihydrochloride). CAS No. 189744-94-3. Molecular formula: C17H22Cl2N4. Mole weight: 353.29. | |
| Ro 10-5824 dihydrochloride | Ro 10-5824 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 189744-94-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 106-9920 | Ro 106-9920, a cell-permeable tetrazolopyridazine-phenylsulfoxide compound, is a small molecule inhibitor of NF-κB-dependent expression of TNF-α, interleukin-1β, and interleukin-6 (IC50 < 1 μM in human peripheral blood mononuclear cells). Synonyms: Ro 106-9920; Ro106-9920; Ro-106-9920; 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine. Grades: ≥99% by HPLC. CAS No. 62645-28-7. Molecular formula: C10H7N5OS. Mole weight: 245.26. | |
| Ro 106-9920 | Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. Group: Biochemicals. Alternative Names: 6- (Phenylsulfinyl) tetrazolo[1, 5-b]pyridazine. Grades: Highly Purified. CAS No. 62645-28-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| RO1138452 | RO1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Synonyms: RO-1138452; RO1138452; RO 1138452; CAY10441; CAY-10441; CAY 10441; N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine. CAS No. 221529-58-4. Molecular formula: C19H23N3O. Mole weight: 309.413. | |
| Ro 1138452 hydrochloride | Ro 1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Synonyms: Ro 1138452 hydrochloride; Ro1138452 hydrochloride; Ro-1138452 hydrochloride; 4,5-Dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imidazol-2-amine hydrochloride; Ro 1138452 Hcl. Grades: ≥98% by HPLC. Molecular formula: C19H23N3O.HCl. Mole weight: 345.87. | |
| Ro 1138452 hydrochloride | Ro 1138452 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 15-4513 | Ro 15-4513. Group: Biochemicals. Grades: Purified. CAS No. 91917-65-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 15-4513 | Ro 15-4513, a high affinity benzodiazepine ligand, acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Uses: Affinity labels. Synonyms: Ro 15-4513; Ro 154513; Ro-15-4513; 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester. Grades: ≥98% by HPLC. CAS No. 91917-65-6. Molecular formula: C15H14N6O3. Mole weight: 326.31. | |
| Ro15-4513 | Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR) [1]. Ro15-4513 is a potent ethanol antagonist [2]. Ro15-4513 has anti-anxiety effect [3]. Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 91917-65-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103476. | |
| Ro18-5362 | Ro18-5362 is the less active prodrug of Ro 18-5364 which is an extremely potent and rapid inhibitor of the gastric mucosal (H+ + K+)-ATPase. Synonyms: 2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfanyl]-5,5,7,7-tetramethyl-3H-cyclopenta[f]benzimidazol-6-one; Ro-18-5362. CAS No. 101387-97-7. Molecular formula: C22H25N3O2S. Mole weight: 395.52. | |
| Ro 19-4603 | Ro 19-4603 is a novel potent partial inverse agonist of benzodiazepine (BZ) receptors. Ro19-4603 binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Synonyms: 5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester; Ro19-4603; Ro 19-4603; Ro-19-4603. Grades: ≥99% by HPLC. CAS No. 99632-94-7. Molecular formula: C15H17N3O3S. Mole weight: 319.38. | |
| Ro 19-4603 | Ro 19-4603. Group: Biochemicals. Grades: Purified. CAS No. 99632-94-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 20-1724 | Ro 20-1724. Group: Biochemicals. Grades: Purified. CAS No. 29925-17-5. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Ro 20-1724 | Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. Synonyms: Ro20-1724; Ro 20-1724; Ro-20-1724. 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone; 4-[(3-Butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone; 4-(3-Butoxy-4-methoxy benzyl)-2-imidazolidinone; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidone; DL-4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Roche 20-1724. Grades: ≥99% by HPLC. CAS No. 29925-17-5. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
| Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) | A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50=2uM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 29925-17-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| RO 20-1724, cAMP-specific Phosphodiesterase Inhibitor (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) | Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 29925-17-5. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
| Ro 25-6981 | Ro 25-6981, structurally related to ifenprodil and with no affinity for the known binding sites of non-competitive antagonists such as phencyclidine or MK-801, is a selective and activity-dependent blocker of NMDA receptors containing the NR2B subunit. Synonyms: 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol;(Z)-but-2-enedioic acid Ro 25-6981 (Maleate) Ro 25-6981 maleate 169274-78-6 1312991-76-6 SCHEMBL16669133 C22H29NO2.C4H4O4 4008AH 4-((1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methyl. Grades: >98 %. CAS No. 169274-78-6. Molecular formula: C22H29NO2.C4H4O4. Mole weight: 455.54. | |
| Ro 25-6981 | Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 169274-78-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-13993. | |
| RO 25-6981 hydrochloride | RO 25-6981 hydrochloride is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit. Synonyms: Ro 256981 HCl; Ro 25 6981 HCl; Ro 25-6981 HCl; 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol hydrochloride. Grades: 99%. CAS No. 919289-58-0. Molecular formula: C22H29NO2.HCl. Mole weight: 375.93. | |
| Ro 25-6981 maleate | Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro. Group: Biochemicals. Alternative Names: (αR, βS)-α-(4-Hydroxyphenyl)- β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate. Grades: Highly Purified. CAS No. 1312991-76-6. Pack Sizes: 1mg, 10mg, 50mg. Molecular Formula: C22H29NO2.C4H4O4, Molecular Weight: 455.55. US Biological Life Sciences. | Worldwide |
| Ro 25-6981 Maleate | The Maleate salt form of Ro 25-6981 which is a NMDA receptors blocker and has been found to exhibit neuroprotectant activity in vitro and in vivo. IC50: 9 nM. Uses: The maleate salt form of ro 25-6981 which is a nmda receptors blocker and has been found to exhibit neuroprotectant activity in vitro and in vivo. Synonyms: Ro 25-6981 Maleate; Ro25-6981 Maleate; Ro-25-6981 Maleate; αR-(4-hydroxyphenyl)-βS-methyl-4-(phenylmethyl)-1-piperidinepropanol, 2Z-butenedioate. Grades: 98%. CAS No. 1312991-76-6. Molecular formula: C26H33NO6. Mole weight: 455.54. | |
| Ro 25-6981 Maleate | Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson's disease (PD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1312991-76-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13993A. | |
| Ro 26-4550 trifluoroacetate | Ro 26-4550 trifluoroacetate. Group: Biochemicals. Grades: Purified. CAS No. 1217448-66-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ro 26-4550 trifluoroacetate | Ro 26-4550 trifluoroacetate is a competitive inhibitor of IL-2/ IL-2Rα receptor interaction. Synonyms: methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate; 2,2,2-trifluoroacetic acid; Ro26-4550; Ro-26-4550 trifluoroacetate; Ro 26-4550 trifluoroacetate; Ro264550 trifluoroacetate. CAS No. 1217448-66-2. Molecular formula: C26H30N4O3.CF3CO2H. Mole weight: 560.57. | |
| Ro 27-3225 | Ro 27-3225 is a potent and selective melanocortin 4 receptor (MC4R) agonist. CAS No. 274682-89-2. Molecular formula: C39H52N12O6. Mole weight: 784.90. | |
| RO 28-0450 | RO 28-0450 is a glucokinase GK agonist. Synonyms: RO 28-1674; RO-28-1674; RO 28 1674; RO-28 1674; RO281674; 3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide. Grades: 98%. CAS No. 300352-96-9. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| RO 28-1674 | RO 28-1674 is a glucokinase GK agonist. Synonyms: RO 28-1674; RO 28 1674; RO-28-1674; RO-28 1674; RO281674; (S)-3-cyclopentyl-2-(4-(methylsulfonyl)phenyl)-N-(thiazol-2-yl)propanamide. Grades: 99%. CAS No. 599164-57-5. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| Ro 28-1675 | A cell-permeable thiazolyl-propanamide compound that acts as a glucokinase (GK) activator by increasing Vmax and decreasing [S]1/2 of GK-catalyzed reaction as well as freeing GK from the inhibitory action of GK regulatory protein (GKRP), resulting in increased. Induces GK nuclear-to-cytosol translocation in primary rat hepatocytes and reduces glucose concentration for insulin secretion stimulation from isolated rat pancreatic islets (threshold [glucose] = 3 mM vs 6 mM with or without 3 μM Ro-28-1675). Exhibits in vivo glucose-lowering and insulin-releasing activity in non-diabetic C57BL/6 mice and Wistar rats and is efficacious in several murine and rodent type II diabetes mellitus (T2DM) models (10 to 50 mg/kg via p.o.). Does not affect hexokinase I or II activity. Synonyms: RO28-1675; RO-28-1675; RO 28-1675; RO028-1675; RO-028-1675; RO 028-1675; RO281675; RO 281675; RO-281675; Ro 0281675; Ro-0281675; Ro0281675. Grades: >98%. CAS No. 300353-13-3. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| RO-3 | RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively). RO-3 is used in a combination of compounds to develop a substance used for alleviating pain and skin disorders. Synonyms: 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine; RO-3; RO 3; RO3. Grades: ≥98% by HPLC. CAS No. 1026582-88-6. Molecular formula: C16H22N4O2. Mole weight: 302.37. | |
| RO-3 | RO-3. Group: Biochemicals. Grades: Purified. CAS No. 1026582-88-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| RO-3 | RO-3 is a potent, CNS-penetrant, and orally active P2X 3 and P2X 2/3 antagonist with pIC 50 s of 5.9 and 7.0 for human homomultimeric P2X 3 and heteromultimeric P2X 2/3 receptors, respectively. RO-3 shows selectivity for P2X 3 and P2X 2/3 over all other functional homomultimeric P2X receptors (IC 50 >10 μM at P2X 1,2,4,5,7 ) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1026582-88-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19978. | |
| RO314724 | RO314724 is a MMP and HDAC inhibitor. Synonyms: RO 314724; RO-314724; (R)-N-(N-(2-(2-(Hydroxyamino)-2-oxoethyl)-4-methyl-1-oxopentyl)-L-leucyl)-L-alanine ethyl ester. CAS No. 112105-54-1. Molecular formula: C19H35N3O6. Mole weight: 401.50. | |
| RO31-8220 | Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate or diacylglycerols by 95%. Ro-31-8220 showed the apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals. Moreover, the ability of Ro-31-8220 to induce apoptotic activation was completely inhibited by the over-expression of the apoptotic suppressor gene, Bcl-2, in the cells. Uses: Enzyme inhibitors. Synonyms: RO31-8220; RO 31-8220; RO-31-8220; RO318220. Grades: 0.98. CAS No. 125314-64-9. Molecular formula: C25H23N5O2S. Mole weight: 457.552. | |
| Ro 31-8220 mesylate | Ro 31-8220 mesylate. Group: Biochemicals. Grades: Purified. CAS No. 138489-18-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ro 31-8220 Mesylate | Ro 31-8220 inhibits rat brain PKC activity with IC50 of 23 nM, and does not show any high degree of selectivity between PKC-α, PKC-β, PKC-γ, and PKC-&epsilon. Synonyms: RO31-8220; RO 31-8220; RO31-8220; RO318220; RO-318220; RO 318220; RO31-8220 mesylate; Bisindolylmaleimide IX; BIM IX.Bisindolylmaleimide IX Mesylate. Grades: >98%. CAS No. 138489-18-6. Molecular formula: C25H23N5O2S.CH4O3S. Mole weight: 553.65. | |
| RO3201195 | RO3201195 (compound 1) is an inhibitor of p38 MAPK. RO3201195 inhibits WS cell proliferation with IC 50 value of 190 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 249937-52-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-118612. | |
| RO3201195 | RO3201195 is an orally bioavailable and highly selective inhibitor of p38 MAPK which was selected for advancement into Phase I clinical trials. Synonyms: RO-3201195; RO 3201195; (5-Amino-1-(4-fluoro-phenyl)-1H-pyrazol-4-yl)-(3-(2,3-dihydroxy-propoxy)-phenyl)-methanone. CAS No. 249937-52-8. Molecular formula: C19H18FN3O4. Mole weight: 371.36. | |
| Ro 32-0432 hydrochloride | Ro 32-0432 hydrochloride is a selective and orally active inhibitor of PKC displaying a 10-fold greater selectivity for PKC-&alpha (IC50 = 9.3 nM); and a 4-fold greater selectivity for PKC-βI over PKC- &epsilon (IC50 = 108 nM). Synonyms: Ro 32-0432; Ro 320432; Ro-32-0432. 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride; RO 32-0432 HCL; RO 32-0432 HYDROCHLORIDE; BISINDOLYLMALEIMIDE XI, HCL; BISINDOLYLMALEIMIDE XI HYDROCHLORIDE; BISINDOLYLMALEIMIDE XL, HCL; BISINDOYLMALEIMIDE XI HYDROCHLORIDE. Grades: ≥99% by HPLC. CAS No. 151342-35-7. Molecular formula: C28H28N4O2.HCl. Mole weight: 489.01. | |
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