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| Product | Description | |
|---|---|---|
| RXFP1 Agonist (2-Isopropoxy-N- (2- (3- (trifluoro methyl sulfonyl) phenylcarbamoyl) phenyl) benzamide, LGR7 Agonist, Relaxin/Insulin-like Family Peptide Receptor 1 Agonist, Leucine-Rich Repeat-Containing GPCR 7 Agonist) | A cell-permeable 2-acetamido-N-phenylbenzamide that selectively activates human, but not mouse, LGR7/RXFP1-mediated cAMP induction (EC50 = 200nM in THP1) via allosteric interaction with the ECL3 region without competing against ECL2-mediated relaxin binding or affecting AVPR1B- or LGR8/RXFP2-mediated cAMP induction. Although shown to be ~150-fold and 500-fold less potent than relaxin (RLX), respectively, in VEGF mRNA induction and cellular impedance assays, pharmacokinetic studies reveal superior in vivo stability to RLX and in vivo bioavailability in mice via oral (Cmax/Tmax = 604nM/plasma/1h and 1026ng/g heart/1.5h; 30mg/kg) or intraperitoneal (Cmax/Tmax = 9.29uM/plasma/1h and 28.6uMol/kg heart/1h; 30mg/kg) administration with good aqueous solubility (7uM in PBS). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| RXR?, ligand binding domain, (200-462), GST tagged human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| RY785 | RY785 is a selective inhibitor of Kv2.1 voltage-gated potassium channels (IC50 = 0.05 μM) that does not affect Cav2 calcium channels. Uses: Designed for use in research and industrial production. Additional or Alternative Names: RY785; RY-785; RY 785. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1393748-80-5. Molecular formula: C21H20N4O2S. Mole weight: 392.48. Purity: >98%. IUPACName: 3-methoxy-α-methyl-N-[2-(4-thiazolyl)-1H-benzimidazol-6-yl]-benzenepropanamide. Canonical SMILES: O=C(NC1=CC=C2N=C(C3=CSC=N3)NC2=C1)C(C)CC4=CC=CC(OC)=C4. Product ID: ACM1393748805. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Ryanodine | Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca 2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa. Uses: Scientific research. Group: Natural products. CAS No. 15662-33-6. Pack Sizes: 1 mg. Product ID: HY-103306. |  |
| Ryanodine | Ryanodine. Group: Biochemicals. Grades: Purified. CAS No. 15662-33-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Rye Flour | certified Reference Material. Group: Food matrix crmsprocess materials, geological, cement & soils. | |
| Rye Grass | certified Reference Material. Group: Food matrix crms. | |
| RyR-Calstabin Interaction Stabilizer, S107 (7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107) | A cell-permeable, orally active benzothiazepine that effectively blocks leaky intracellular calcium release by preventing the dissociation/depletion of calstabin from the ryanodine receptor (RyR) complex due to receptor modifications, such as oxidation, S-nitrosylation, hyperphosphorylation, or mutation (complete blockage of 1 mM tetracaine-induced leakage in murine RyR2 S2808D+/+ myocytes at 1uM). Shown to prevent stress-induced cognitive dysfunction by stabilizing RyR2-calstabin-2 (FKBP12.6) interaction in brain (75mg/kg/day; p.o.) and maintain exercise capacity by stabilizing RyR1-calstabin-1 (FKBP12) interaction in skeletal muscle (2. 5ug/0. 25uL/h/animal; s.c) in mice, as well as restore normal cardiac function (20mg/kg/day; s.c) in mice with R2474S or S2808D RyR2 mutation in vivo.Primary Target:RyR2. Group: Biochemicals. Alternative Names: 7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107. Grades: Highly Purified. CAS No. 927871-76-9. Pack Sizes: 10mg. Molecular Formula: C??H??NOS, Molecular Weight: 209.3. US Biological Life Sciences. | Worldwide |
| Ryuvidine | Ryuvidine. Group: Biochemicals. Grades: Purified. CAS No. 265312-55-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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