A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively). Synonyms: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride. Grades: ≥99%. CAS No. 1784252-84-1. Molecular formula: C27H41N5O2·2HCl. Mole weight: 540.57.
C 021 dihydrochloride
C 021 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 864289-85-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
C086
C086 inhibits Hsp90 and BCR-ABL, resulting in decreased proliferation of tumor cells, including imatinib-resistant cells. Synonyms: C086; C 086; C-086. Grades: >98%. CAS No. 1160107-44-7. Molecular formula: C29H28O8. Mole weight: 504.53.
C-1
C-1 is a protein kinase inhibitor selecitive for PKG, PKA and PKC (IC50 = 4, 8 and 12 μM, respectively) and is widely used as a ROCK inhibitor. Synonyms: HA 100; HA100; HA-100; 5-Piperazin-1-ylsulfonylisoquinoline; 1-(5-Isoquinolinesulfonyl)piperazine. Grades: ≥99% by HPLC. CAS No. 84468-24-6. Molecular formula: C13H15N3O2S. Mole weight: 277.34.
C-1
C-1. Group: Biochemicals. Grades: Purified. CAS No. 84468-24-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
C100 Technical
C100 Technical. Group: Polymerschemical resins.
C101 Dye
C101 Dye is ruthenium (Ru) based organic dye that can be used as a heteroleptic thiophene-based sensitizer. It has a high extinction coefficient of 17500 Lmol-1cm-1 and facilitates the enhancement of optoelectronic properties of electrochemical devices. Uses: A ruthenium sensitizer with high molar extinction coefficient for high-performance dye-sensitized solar cellsalong with an acetonitrile-based electrolyte; the c101 sensitizer achieved a high efficeincy of 11.0-11.3% in the dye-sensitized solar cells under the illumination of am 1.5g full sunlight. Group: Organic solar cell (opv) materials. Alternative Names: cis-Bis(isothiocyanato)(2,2'-bipyridyl-4,4'-dicarboxylato)(4,4'-bis(5-hexylthiophen-2-yl)-2,2'-bipyridyl)ruthenium(II), Ruthenate(2-), [[2, 2'-bipyridine]-4, 4'-dicarboxylato(2-)-N1, N1'][4, 4'-bis(5-hexyl-2-thienyl)-2, 2'-bipyridine-N1, N1']bis(thiocyanato-N)-, hydrogen (1:2). CAS No. 1224601-35-7. Pack Sizes: 250 mg in glass insert. OC (C1=CC (C2=CC (C (O)=O)=CC=N2)=NC=C1)=O. S=C=N[Ru]N=C=S. CCCCCCC (S3)=CC=C3C4=CC=NC (C5=NC=CC (C6=CC=C (CCCCCC)S6)=C5)=C4. 1S/C30H36N2S2. C12H8N2O4. 2CNS. Ru/c1-3-5-7-9-11-25-13-15-29 (33-25)23-17-19-31-27 (21-23)28-22-24 (18-20-32-28)30-16-14-26 (34-30)12-10-8-6-4-2; 15-11 (16)7-1-3-13-9 (5-7)10-6-8 (12 (17)18)2-4-14-10; 2*2-1-3; /h13-22H, 3-12H2, 1-2H3; 1-6H, (H, 15, 16) (H, 17, 18); ; ; /q; ; 2*-1; +2. BXXRBPUFQSDMHJ-UHFFFAOYSA-N.
C104
C104. Group: Polymers.
C106 Dye
C106 Dye. Uses: A ruthenium dye for high-efficiency dye-sensitized solar cellspower conversion efficiencies of 11.7-12.1% achieved in high-efficiency dye-sensitized solar cells under air-mass 1.5g simulated sunlights. Group: Organic solar cell (opv) materials. Alternative Names: Cis-bis(isothiocyanato)(2,2 inverted exclamation marka-bipyridyl-4,4 inverted exclamation marka-dicarboxylato)( 4,4 inverted exclamation marka-bis(5-(hexylthio)thiophen-2-yl)-2,2 inverted exclamation marka-bipyridyl)ruthenium(II). CAS No. 1152310-69-4. Pack Sizes: 250 mg in glass insert. Molecular formula: 1014.32. Mole weight: C44H44N6O4RuS6. CCCCCCSC1=CC=C (S1)C2=CC (=NC=C2)C3=NC=CC (=C3)C4=CC=C (S4)SCCCCCC. C1=CN=C (C=C1C (=O)O)C2=NC=CC (=C2)C (=O)O. C (=[N-])=S. C (=[N-])=S. [Ru+2]. InChI=1S/C30H36N2S4. C12H8N2O4. 2CNS. Ru/c1-3-5-7-9-19-33-29-13-11-27 (35-29)23-15-17-31-25 (21-23)26-22-24 (16-18-32-26)28-12-14-30 (36-28)34-20-10-8-6-4-2; 15-11 (16)7-1-3-13-9 (5-7)10-6-8 (12 (17)18)2-4-14-10; 2*2-1-3; /h11-18, 21-22H, 3-10, 19-20H2, 1-2H3; 1-6H, (H, 15, 16) (H, 17, 18); ; ; /q; ; 2*-1; +2. ZEXAHKWZTIWSCT-UHFFFAOYSA-N.
C106 Dye, 90%
C106 Dye, 90%. Group: Dye-sensitized solar cell (dssc) materials. CAS No. 1152310-69-4.
C10 Bisphosphonate
C10 Bisphosphonate is an inhibitor for acid sphingomyelinase. C10 Bisphosphonate is promising for research of inflammatory lung diseases, cystic fibrosis and atherosclerosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15049-93-1. Pack Sizes: 1 mg. Product ID: HY-48917.
c10e3
c10e3. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Decyltriglycol, Triethylene glycol monodecyl ether, Decyl triethylene glycol ether, Polyoxyethylene (3) decyl ether, C10E3, SBB056742, Triethyleneglycol monodecyl ether solution, 2-(2-(2-decyloxy-ethoxy)-ethoxy)-ethanol, Triethyleneglycol monodecyl ether 1 mM solution, Detergent Screening Solution 10/Fluka kit no 66317, 4669-23-2, 2-[2-(2-decyloxyethoxy)ethoxy]ethan-1-ol, Triethylene glycol, decyl ether, AC1LB1EB, Polyoxyethylene 3 decyl ether, 41957_FLUKA, 90446_FLUKA, 90446_SIGMA, CTK8G3600, 2-[2-(2-decoxyethoxy)ethoxy]ethanol. Product Category: Heterocyclic Organic Compound. CAS No. 4669-23-2. Molecular formula: C16H34O4. Mole weight: 290.44. Purity: 0.96. IUPACName: 2-[2-(2-decoxyethoxy)ethoxy]ethanol. Canonical SMILES: CCCCCCCCCCOCCOCCOCCO. Density: 0.936 g/mL at 20ºC(lit.). Product ID: ACM4669232. Alfa Chemistry ISO 9001:2015 Certified. Categories: C103.
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1220890-25-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145405.
Ceramide is one of the simplest sphingolipids, consisting of a sphingosine base N-linked to a fatty acid, and is a membrane mediator for cell-signaling events. N-Acyl chain length of membrane ceramides can influence bidimensional transitions, condensed domain morphology, and interfacial thickness. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]dodecanamide; N- [ (1S, 2R, 3E) -2-Hydroxy-1- (hydroxymethyl) -3-heptadecenyl] dodecanamide; [R- [R*, S*- (E) ] ] -N- [2-Hydroxy-1- (hydroxymethyl) -3-heptadecenyl] dodecanamide; N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine. Grades: Highly Purified. CAS No. 74713-60-3. Pack Sizes: 5mg. US Biological Life Sciences.
C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease [1] [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine. CAS No. 74713-60-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-100353.
C12-Sphingosine
C12-Sphingosine. Group: Biochemicals. Alternative Names: [R-[R*,S*-(E)]]-2-Amino-4-dodecene-1,3-diol; (2S,3R,4E)-2-Amino-4-dodecene-1,3-diol. Grades: Highly Purified. CAS No. 128427-86-1. Pack Sizes: 10mg. Molecular Formula: C12H25NO2, Molecular Weight: 215.33. US Biological Life Sciences.
Worldwide
C-1311 dihydrochloride
C-1311 is a Fms-like tyrosine kinase 3 inhibitor under the development of Antisoma. It has shown activity in experimental tumour models both in vitro and in nude mice. C-1311 can delay progression of cells through the S phase which was followed by G2 arrest at the EC(99) dose as a mitosis inhibitor. Phase I clinical trials for treatment of solid tumours and a phase II clinical trials for the treatment of breast cancer were discontinued. Uses: Anticancer agents. Synonyms: Imidacrine; XLS-002; C-1311 dihydrochloride; XLS 002; C 1311 dihydrochloride; XLS002; C1311 dihydrochloride; Symadex; Imidazoacridinone; CHEMBL3545337;5-(2-(diethylamino)ethylamino)--8-hydroxy-6H-imidazo(4,5,1-de)acridin-6-one. Grades: 98%. CAS No. 138154-55-9. Molecular formula: C20H26Cl2N4O3. Mole weight: 441.35.
c-[1-(3-Fluorophenyl)-cyclopentyl]-methylamine
c-[1-(3-Fluorophenyl)-cyclopentyl]-methylamine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SBB014731, 1-[1-(3-fluorophenyl)cyclopentyl]methanamine, [(3-fluorophenyl)cyclopentyl]methylamine, 359715-61-0, AGN-PC-015OTJ, SureCN7196726, CTK7E3883, MolPort-000-116-683, STK523524, AKOS000112534, AG-B-18112, MCULE-9553644540, [1-(3-fluorophenyl)cyclopentyl]methanamine, [1-(3-Fluorophenyl)cyclopentyl]methylamine, KB-216865, ST4142915, Cyclopentanemethanamine, 1-(3-fluorophenyl)-, C-[1-(3-Fluoro-phenyl)-cyclopentyl]-methylamine. Product Category: Heterocyclic Organic Compound. CAS No. 359715-61-0. Molecular formula: C12H16FN. Mole weight: 193.27. Purity: 0.96. IUPACName: [1-(3-fluorophenyl)cyclopentyl]methanamine. Canonical SMILES: C1CCC(C1)(CN)C2=CC(=CC=C2)F. Density: 1.071g/cm³. Product ID: ACM359715610. Alfa Chemistry ISO 9001:2015 Certified.
C14-Ceramide
C14-Ceramide. Group: Biochemicals. Alternative Names: N-Myristoyl-D-sphingosine; N- [ (1S, 2R, 3E) -2-hydroxy-1- (hydroxymethyl) -3-heptadecenyl] tetradecanamide; N-[2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]-, [R-[R*,S*-(E)]]tetradecanamide. Grades: Highly Purified. CAS No. 34227-72-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C32H63NO3. US Biological Life Sciences.
Worldwide
C14 Ceramide (d18:1/14:0)
C14 Ceramide (d18:1/14:0) is an endogenous ceramide produced by ceramide synthetase 6, which can be used for Parkinson's and diabetes research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 123408-74-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-124177A.
C14 Ceramide (N-Myristoyl-D-sphingosine)
C14 Ceramide (N-Myristoyl-D-sphingosine). Group: Biochemicals. Alternative Names: N-Myristoyl-D-sphingosine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
C14 dihydroceramide
C14 dihydroceramide. Group: Biochemicals. Alternative Names: N-Myristoylsphinganine. Grades: Highly Purified. CAS No. 61389-70-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C32H65NO3. US Biological Life Sciences.
Worldwide
C14TKL-1
C14TKL-1 is an endogenous human tachykinin-like peptide and a potent NK1 receptor agonist (EC50 = 1 nM). Synonyms: H-Arg-His-Arg-Thr-Pro-Met-Phe-Tyr-Gly-Leu-Met-NH2; L-arginyl-L-histidyl-L-arginyl-L-threonyl-L-prolyl-L-methionyl-L-phenylalanyl-L-tyrosyl-glycyl-L-leucyl-L-methioninamide; Chromosome 14 tachykinin-like peptide 1; C14TKL1; C14TKL 1. Grades: ≥95%. CAS No. 1423381-12-7. Molecular formula: C63H98N20O13S2. Mole weight: 1407.71.
C14TKL-1
C14TKL-1. Group: Biochemicals. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
C14TKL-1 acetate
C14TKL-1 acetate is an endogenous human tachykinin-like peptide and a potent NK1 receptor agonist (EC50 = 1 nM). Synonyms: H-Arg-His-Arg-Thr-Pro-Met-Phe-Tyr-Gly-Leu-Met-NH2.CH3CO2H; L-arginyl-L-histidyl-L-arginyl-L-threonyl-L-prolyl-L-methionyl-L-phenylalanyl-L-tyrosyl-glycyl-L-leucyl-L-methioninamide acetate; Chromosome 14 tachykinin-like peptide 1 acetate; C14TKL1 acetate; C14TKL 1 acetate. Grades: ≥95%. Molecular formula: C65H102N20O15S2. Mole weight: 1467.75.
C16
C16 is an inhibitor of RNA-activated protein kinase (PKR) (IC50 = 210 nM). It is an imidazolo-oxindole derivative that binds to ATP-binding site of PKR and rescues PKR-dependent translation block in vitro. C16 has neuroprotective activity against cell damage in human neuroblastoma cells and neuroinflammation in acute excitotoxic rat model. Synonyms: GW-506033X; GW 506033X; GW506033X; C16, PKR Inhibitor; 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one. Grades: ≥98% by HPLC. CAS No. 608512-97-6. Molecular formula: C13H8N4OS. Mole weight: 268.29.
C16
C16. Group: Biochemicals. Grades: Purified. CAS No. 608512-97-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
C16-Ceramide. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-hexadecanamide; (2S, 3R, 4E) -2-N-Palmitoyl octadecasphinga-4-ene . Grades: Highly Purified. CAS No. 24696-26-2. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C34H67NO3. US Biological Life Sciences.
Worldwide
C16-Ceramide
C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding [1]. Uses: Scientific research. Group: Natural products. CAS No. 24696-26-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100354.
C16 Ceramide-1-phosphate (d18:1/16:0) ammonium
C16 Ceramide-1-phosphate (d18:1/16:0) (ammonium) (C16 Ceramide-1-phosphate (ammonium); Ceramide-1-phosphate (d18:1/16:0) (ammonium)) is an ester product. Uses: Scientific research. Group: Signaling pathways. Alternative Names: C16 Ceramide-1-phosphate ammonium; Ceramide-1-phosphate (d18:1/16:0) ammonium; CerP(d18:1/16:0) ammonium. CAS No. 1246303-22-9. Pack Sizes: 5 mg. Product ID: HY-145467.
C16 Ceramide-1-phosphate (d18:1/16:0) ammonium salt
C16 Ceramide-1-phosphate (C16 C1P) is one of the main forms of C1P found in cells. It is created by phosphorylation of by ceramide kinase. It activates cytosolic phospholipase A2α (PLA2α) and stimulates the release of arachidonic acid in A549 cells. Synonyms: C16 C1P; C16 Ceramide-1-phosphate; N-(hexadecanoyl)-sphing-4-enine-1-phosphate; CerP(d18:1/16:0). Grades: ≥98%. CAS No. 1246303-22-9. Molecular formula: C34H71N2O6P. Mole weight: 634.91.
A predominant, rather hydrophobic natural ceramide. Activates a cytosolic serine/threonine protein phosphatase in T9 cells; induces EGF receptor phosphorylation in A-431 cells; stimulates ceramide-activated protein kinase. Group: Biochemicals. Alternative Names: N-Palmitoyl-D-Sphingosine; N-Hexadecanoyl-D-sphingosine; Palmitoyl Ceramide. Grades: Highly Purified. CAS No. 24696-26-2. Pack Sizes: 5mg. US Biological Life Sciences.
C16 Dihydroceramide (N-Hexadecanoyl sphinganine, N-Palmitoylsphinganine). Group: Biochemicals. Alternative Names: N-Hexadecanoyl sphinganine; N-Palmitoyl sphinganine. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
C16 Galactosyl(α) Ceramide (d18:1/16:0)
It is a glycosphingolipid that contains a galactose moiety attached to a ceramide acylated with palmitic acid. Synonyms: D-galactosyl-α-1,1'-N-palmitoyl-D-erythro-sphingosine; Hexadecanamide, N-[(1S,2R,3E)-1-[(α-D-galactopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]-; α C16 Galactosylceramide (d18:1/16:0); C16 α-D-galactosyl ceramide; N-(hexadecanoyl)-1-α-galactosyl-sphing-4-enine; N-((2S,3R,E)-3-hydroxy-1-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octadec-4-en-2-yl)palmitamide; N-[(2S,3R,4E)-1-(α-D-Galactopyranosyloxy)-3-hydroxy-4-octadecen-2-yl]hexadecanamide; α-GalCer(d18:1/16:0). Grades: >99%. CAS No. 2260795-77-3. Molecular formula: C40H77NO8. Mole weight: 700.04.
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide. C16 PEG2000 Ceramide can be used for lipid carrier to delivery. C16 PEG2000 Ceramide induces autophagy. C16 PEG2000 Ceramide can be used for cancer research [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: C16 PEG Ceramide (MW 2000). CAS No. 212116-78-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-144005.
C16-Sphingosine
C16-Sphingosine. Group: Biochemicals. Alternative Names: (2S,3R,4E)-2-Amino-4-hexadecene-1,3-diol; (E)-D-Erythro-2-amino-4-hexadecene-1,3-diol; [R-[R*,S*-(E)]]-2-Amino-4-hexadecene-1,3-diol; C16-Sphingosine; 16:Sphingosine; C16-Sphingosine; Hexadecasphing-4-enine; Hexadecasphingenine. Grades: Highly Purified. CAS No. 6982-9-8. Pack Sizes: 10mg. Molecular Formula: C16H33NO2, Molecular Weight: 271.44. US Biological Life Sciences.
C17:0 GA2, the renowned biomarker utilized in the biomedical realm, serves as an undeniably valuable asset for diagnosing the genetic ailment, namely Gaucher disease, which is fundamentally instigated by the inadequacy of glucocerebrosidase. Remarkably, the levels of C17:0 GA2 are considerably heightened in both blood and urine of afflicted individuals, rendering it an efficacious tool for the prompt detection and progressive monitoring of the disease. Synonyms: C17:0 Galabiosylceramide. Grades: >99%. CAS No. 2315262-51-0. Molecular formula: C47H89NO13. Mole weight: 876.21.
C17:0 iGB3
C17:0 iGb3, a synthetic analogue of iGb3 that plays a pivotal role in immunostimulation. With its unique glycolipid composition, this powerful compound has exhibited promising potential in the treatment of cancer by priming the immune system against malignant cells. Moreover, recent research suggests that C17:0 iGb3 may also hold therapeutic promise in the management of infectious diseases and autoimmune disorders. Discover the cutting-edge scientific complexities behind C17:0 iGb3 and its potential impact on human health. Synonyms: C17:0 Isoglobotriaosylceramide. Grades: >99%. CAS No. 2315262-50-9. Molecular formula: C53H99NO18. Mole weight: 1038.35.
C-176
C-176 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It is also a central signaling component of the intracellular DNA sensing pathway. Synonyms: STING inhibitor C 176; C176; C 176. Grades: ≥98%. CAS No. 314054-00-7. Molecular formula: C11H7IN2O4. Mole weight: 358.09.
C-178
C-178 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 also blocks palmitoylation (PMA)-induced clustering of STING. It inhibits the CMA-induced phosphorylation of TBK1, which is downstream protein kinase of STING. C-178 prevents the increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs). Synonyms: C178; C 178. Grades: ≥98%. CAS No. 329198-87-0. Molecular formula: C17H10N2O5. Mole weight: 322.27.
C18:1-Ceramide
C18:1-Ceramide is a ceramide subspecies. C18:1-Ceramide can be used in the study of type 2 diabetes [1]. Uses: Scientific research. Group: Natural products. CAS No. 5966-28-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141578.
C188 is a STAT3 inhibitor that inhibits IL-6-stimulated STAT3 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket. C188, in particular, was highly active in inducing apoptosis of the breast cancer cell line MB-MDA-468 in vitro ( EC 50 = 0.7 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: CPD188. CAS No. 823828-18-8. Pack Sizes: 5 mg. Product ID: HY-112338.
C188-9
C188-9 (TTI-101) is a STAT3 inhibitor, with a K d of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TTI-101. CAS No. 432001-19-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112288.
C188-9
C188-9 is a STAT3 inhibitor. HDM-induced airway inflammation, remodeling, and Th2/Th17-type cell accumulation involve STAT3 activation that can be prevented by C188-9 treatment. STAT3 inhibition with C188-9 resulted in attenuated skin fibrosis, myofibroblast accumulation, pro-fibrotic gene expression and collagen deposition in both mouse models of skin fibrosis. C188-9 decreased in vitro dermal fibroblast production of fibrotic genes induced by IL-6 trans-signalling and TGF-β. Finally, TGF-β induced phosphotyrosylation of STAT3 in a SMAD3-dependent manner. Uses: Designed for use in research and industrial production. Additional or Alternative Names: C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084. Product Category: Inhibitors. Appearance: Pinky beige solid powder. CAS No. 432001-19-9. Molecular formula: C27H21NO5S. Mole weight: 471.52. Purity: >98%. IUPACName: N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide. Canonical SMILES: O=S(C1=CC=C(OC)C=C1)(NC2=C3C=CC=CC3=C(O)C(C4=C5C=CC=CC5=CC=C4O)=C2)=O. Product ID: ACM432001199. Alfa Chemistry ISO 9001:2015 Certified. Categories: C/1889 O1 (Davidson).
C18-Ceramide
C18-Ceramide is a bioactive molecule with multiple functions in cells, can cross the blood-brain barrier, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 2304-81-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100355.
C18 Ceramide-13C2,D2
The sphingolipid ceramide. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]octadecanamide-13C2,D2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
C18-Ceramide-d7
C18-Ceramide-d 7 is deuterium labeled C18-Ceramide. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1840942-14-4. Pack Sizes: 500 μg (1.75 mM * 500 μL in Methanol:Chloroform (10:90)); 1 mg; 5 mg. Product ID: HY-100355S1.
The sphingolipid ceramide is a potent inhibitor of the mitochondrial permeability transition pore. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]octadecanamide; D-erythro-1,3-Dihydroxy-2-octadecanoylamido-trans-4-octadecene; N-Stearoyl-C18-sphingosine; N-Stearoyl-D-erythro-sphingosine; N-Stearoyl-D-sphingosine; N-Stearoylsphingenine; N-Stearoylsphingosine. Grades: Highly Purified. CAS No. 2304-81-6. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C36H71NO3, Molecular Weight: 565.95. US Biological Life Sciences.
Worldwide
C18 dihydroceramide
C18 dihydroceramide. Group: Biochemicals. Alternative Names: N- [ (1S, 2R) -2-Hydroxy-1- (hydroxymethyl) heptadecyl] octadecanamide; Dihydroceramide; N-Stearoylsphinganine. Grades: Highly Purified. CAS No. 2304-80-5. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C36H73NO3. US Biological Life Sciences.
Worldwide
C18 Dihydroceramide
C18 Dihydroceramide is an ester product. Uses: Scientific research. Group: Signaling pathways. CAS No. 2304-80-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141580.