A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
C188 is a STAT3 inhibitor that inhibits IL-6-stimulated STAT3 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket. C188, in particular, was highly active in inducing apoptosis of the breast cancer cell line MB-MDA-468 in vitro ( EC 50 = 0.7 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: CPD188. CAS No. 823828-18-8. Pack Sizes: 5 mg. Product ID: HY-112338.
C188-9
C188-9 (TTI-101) is a STAT3 inhibitor, with a K d of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TTI-101. CAS No. 432001-19-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112288.
C188-9
C188-9 is a STAT3 inhibitor. HDM-induced airway inflammation, remodeling, and Th2/Th17-type cell accumulation involve STAT3 activation that can be prevented by C188-9 treatment. STAT3 inhibition with C188-9 resulted in attenuated skin fibrosis, myofibroblast accumulation, pro-fibrotic gene expression and collagen deposition in both mouse models of skin fibrosis. C188-9 decreased in vitro dermal fibroblast production of fibrotic genes induced by IL-6 trans-signalling and TGF-&beta. Finally, TGF-β induced phosphotyrosylation of STAT3 in a SMAD3-dependent manner. Group: Inhibitors. Alternative Names: C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084. CAS No. 432001-19-9. Molecular formula: C27H21NO5S. Mole weight: 471.52. Appearance: Pinky beige solid powder. Purity: >98%. IUPACName: N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide. Canonical SMILES: O=S (C1=CC=C (OC)C=C1) (NC2=C3C=CC=CC3=C (O)C (C4=C5C=CC=CC5=CC=C4O)=C2)=O. Catalog: ACM432001199.
C18-Ceramide
C18-Ceramide is a bioactive molecule with multiple functions in cells, can cross the blood-brain barrier, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 2304-81-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100355.
C18 Ceramide-13C2,D2
The sphingolipid ceramide. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]octadecanamide-13C2,D2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
C18-Ceramide-d7
C18-Ceramide-d 7 is deuterium labeled C18-Ceramide. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1840942-14-4. Pack Sizes: 500 μg (1.75 mM * 500 μL in Methanol:Chloroform (10:90)); 1 mg; 5 mg. Product ID: HY-100355S1.
The sphingolipid ceramide is a potent inhibitor of the mitochondrial permeability transition pore. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]octadecanamide; D-erythro-1,3-Dihydroxy-2-octadecanoylamido-trans-4-octadecene; N-Stearoyl-C18-sphingosine; N-Stearoyl-D-erythro-sphingosine; N-Stearoyl-D-sphingosine; N-Stearoylsphingenine; N-Stearoylsphingosine. Grades: Highly Purified. CAS No. 2304-81-6. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C36H71NO3, Molecular Weight: 565.95. US Biological Life Sciences.
Worldwide
C18 dihydroceramide
C18 dihydroceramide. Group: Biochemicals. Alternative Names: N- [ (1S, 2R) -2-Hydroxy-1- (hydroxymethyl) heptadecyl] octadecanamide; Dihydroceramide; N-Stearoylsphinganine. Grades: Highly Purified. CAS No. 2304-80-5. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C36H73NO3. US Biological Life Sciences.
Worldwide
C18 Dihydroceramide
C18 Dihydroceramide is an ester product. Uses: Scientific research. Group: Signaling pathways. CAS No. 2304-80-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141580.
C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide. It can inhibit rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 8.8 μM. Synonyms: L-erythro Cer(d18:1/18:0); L-erythro Ceramide (d18:1/18:0); N-octadecanoyl-L-erythro-sphingosine. Grades: ≥98%. CAS No. 252039-52-4. Molecular formula: C36H71NO3. Mole weight: 565.95.
C18 L-threo Ceramide (d18:1/18:0)
C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 16.8 μM. Synonyms: N-octadecanoyl-L-threo-sphingosine; L-threo Cer(d18:1/18:0); L-threo Ceramide (d18:1/18:0). Grades: ≥98%. CAS No. 95037-06-2. Molecular formula: C36H71NO3. Mole weight: 565.95.
It is produced by the strain of Streptomyces griseus subsp. cryophilus C-19393. C-19393 E5 has anti-gram-positive and anti-gram-negative bacteria activity and strong β-lactamase inhibition. Synonyms: Antibiotic C 19393E5; C-19393 E(5). CAS No. 83310-72-9. Molecular formula: C13H16N2O6S. Mole weight: 328.34.
C-19 steroid 1α-hydroxylase
The enzyme, characterized from the bacterium Sorangium cellulosum, is a class I cytochrome P-450, and uses ferredoxin as its electron donor. It was shown to act on several C-19 steroid substrates, including testosterone, androstenedione, testosterone-acetate and 11-oxoandrostenedione. Group: Enzymes. Synonyms: CYP260A1. Enzyme Commission Number: EC 1.14.15.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0944; C-19 steroid 1α-hydroxylase; EC 1.14.15.19; CYP260A1. Cat No: EXWM-0944.
C-(1-Bromo-1-deoxy-2,3,4,6-tetra-O-benzoyl-b-D-glucopyranosyl)formamide is a vital component in the development of novel antiviral drugs. Through its unique chemical structure, it exhibits potent antiviral activity against a range of infectious diseases, including influenza and herpes viruses. Synonyms: C-(2,3,4,6-Tetra-O-benzoyl-1-bromo-1-deoxy-b-D-glucopyranosyl)formamide. CAS No. 262849-68-3. Molecular formula: C35H28BrNO10. Mole weight: 702.5.
C20-C24 Alkyl Dimethicone is a type of silicone-based emollient that is often used in cosmetic and personal care formulations, such as lotions, creams, hair conditioners, and sunscreen products. This ingredient is derived from silicon, a naturally occurring mineral element that is widely used in the cosmetic industry due to its emollient, smoothing, and protective properties. C20-C24 Alkyl Dimethicone is a mixture of alkylated silicones, which means it contains molecules of different sizes and structures with carbon chains ranging from 20 to 24 carbons. This blend of silicones can provide various skin and hair benefits such as a smooth and silky texture, improved spreadability, enhanced moisture retention, and reduced dryness and flakiness. Uses: 1. c20-c24 alkyl dimethicone is commonly used as an emollient in various cosmetic formulations such as moisturizers, lotions, and hair care products. 2. it forms a protective barrier on the skin and hair, preventing moisture loss and providing a silky, smooth feel. 3. due to its low viscosity, it can easily penetrate the skin and hair shaft, delivering hydration and nourishment. 4. c20-c24 alkyl d. Group: Emollients/oils/wax. CAS No. 200074-76-6. Appearance: clear, colorless liquid with a silky-smooth texture. Catalog: CI-SC-0403.
C20 Ceramide
C20 Ceramide is a natural 20:0 ceramide that is abundant in the brain [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: N-Arachidoyl-D-sphingosine. CAS No. 7344-2-7. Pack Sizes: 1 mg. Product ID: HY-112016.
C 21. Group: Biochemicals. Grades: Purified. CAS No. 1229236-78-5. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
C 21
C 21 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM) with 5-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1. Synonyms: C21; C-21; N-Acetyl-L-serylglycyl-N5-(2-chloroethanimidoyl)-L-ornithylglycyl-L-lysylglycylglycyl-L-lysylglycyl-L-leucylglycyl-L-lysylglycylglycyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-arginyl-L-lysyl-L-valine. Grades: >98%. CAS No. 1229236-78-5. Molecular formula: C90H161ClN36O24. Mole weight: 2166.92.
C215
C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis , limited non-specific toxicity against mammalian cells, an IC 90 of 16 μM against M. tuberculosis , and efficacy against M. tuberculosis growing in macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912780-51-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-124814.
C22-Ceramide
C22-Ceramide. Group: Biochemicals. Alternative Names: N-[(3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]-docosanamide. Grades: Highly Purified. CAS No. 869501-30-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C40H79NO3. US Biological Life Sciences.
Worldwide
C22-Ceramide
C22-Ceramide (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: N-Behenoyl-D-erythro-sphingosine; Cer d18:1/22:0. CAS No. 27888-44-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154831.
C-(2,3,4,6-Tetra-O-acetyl-1-azido-1-deoxy-a-D-galactopyranosyl)formamide is a valuable compound utilized in the biomedical industry for its potential in treating infectious diseases caused by specific bacteria or viruses. Its structure and chemical properties make it an effective candidate for the development of antiviral or antibacterial drugs. Synonyms: [(2R,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-azido-6-carbamoyloxan-2-yl]methyl acetate; C-(2,3,4,6-TETRA-O-ACETYL-1-AZIDO-1-DEOXY-A-D-GALACTOPYRANOSYL)FORMAMIDE; c-(2,3,4,6-tetra-o-acetyl-1-azido-1-deoxy-alpha-d-galactopyranosyl)formamide; C-(2,3,4,6-Tetra-O-acetyl-1-azido-1-deoxy-alpha-D-galactopyranosyl)formamide?. CAS No. 180904-09-0. Molecular formula: C15H20N4O10. Mole weight: 416.34.
C-(2,3,4,6-Tetra-O-acetyl-1-bromo-1-deoxy-b-D-galactopyranosyl)formamide, an extensively researched and promising biomedical compound, exhibits immense potential for therapeutic applications. With its commendable prowess as a glycosylation reagent in synthesizing glycosides, oligosaccharides, and bioactive molecules, this exceptional product assumes a pivotal role in drug development. Synonyms: [(2R,3S,4S,5R,6S)-3,4,5-Triacetyloxy-6-bromo-6-carbamoyloxan-2-yl]methyl acetate; SCHEMBL8946300; C-(2,3,4,6-TETRA-O-ACETYL-1-BROMO-1-DEOXY-beta-D-GALACTOPYRANOSYL)FORMAMIDE. CAS No. 159895-07-5. Molecular formula: C15H20BrNO10. Mole weight: 456.3.
C-(2,3,4,6-Tetra-O-acetyl-1-hydroxy-b-D-galactopyranosyl)formamide is a compound used in the research of various diseases playing a crucial role in targeting specific cellular pathways associated with compound resistance and cancer progression. Synonyms: [(2R,3S,4S,5R,6R)-3,4,5-triacetyloxy-6-carbamoyl-6-hydroxyoxan-2-yl]methyl acetate; C-(2,3,4,6-TETRA-O-ACETYL-1-HYDROXY-BETA-D-GALACTOPYRANOSYL) FORMAMIDE; C-(2,3,4,6-Tetra-O-acetyl-1-hydroxy-beta-D-galactopyranosyl)formamide?. CAS No. 189633-60-1. Molecular formula: C15H21NO11. Mole weight: 391.33.
C-(2,3,4-Tri-O-acetyl-1-azido-1-deoxy-b-D-galactopyranosyl)formamide, a renowned compound extensively applied within the biomedical industry, emerges as an indubitably vital asset enhancing drug development and research endeavors. It manifests considerable potential in ameliorating an array of ailments, predominantly those entrenched in the realms of cellular and molecular biology. CAS No. 189633-67-8. Molecular formula: C12H16N4O8. Mole weight: 344.3.
C-(2,3,4-Tri-O-acetyl-1-hydroxy-b-D-galactopyranosyl)formamide is a biomedical product used for the study of certain diseases. It acts as a formamide derivative of galactose, which exhibits potential antitumor activity against various cancer types. CAS No. 189633-66-7. Molecular formula: C12H17NO9. Mole weight: 319.3.
C24:1 b-D-Galactosyl ceramide
C24:1 b-D-Galactosyl ceramide is a renowned compound prevalent in the ever-evolving biomedical realm, specifically tailored for the research of diverse afflictions, including Gaucher disease and Fabry disease. Synonyms: Galactosyl-b-1,1 N-nervonoyl-D-erythro-sphingosine. Grades: >99%. CAS No. 17283-91-9. Molecular formula: C48H91NO8. Mole weight: 810.24.
C24:1Ceramide
C24:1Ceramide. Group: Biochemicals. Alternative Names: Nervonic ceramide. Grades: Highly Purified. CAS No. 54165-50-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C42H81NO3. US Biological Life Sciences.
Worldwide
C24:1-Ceramide
C24:1-Ceramide is one of the most abundant naturally occurring ceramide. Ceramides regulates many diverse biological activities, such as cell apoptosis , cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 54164-50-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-134575.
C24:1 Ceramide (Nervonic Ceramide)
Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of phospholipase C, appropriately named sphingomyelinase. Group: Biochemicals. Alternative Names: Nervonic Ceramide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
C24:1 Mono-sulfo galactosyl (alpha) ceramide (d18:1/24:1) Ammonium salt
C24:1 Mono-sulfo galactosyl (alpha) ceramide (d18:1/24:1) Ammonium salt is a valuable compound serving as a formidable biomarker facilitating the comprehensive investigation of ceramide involvement in diverse pathological conditions, spanning from malignancies such as cancer, to metabolic disorders like diabetes is and even neurodegenerative ailments. Synonyms: 3-O-Sulfo-D-galactosyl-alpha-1,1'-N-Nervonoyl-D-erythro-sphingsoine (ammonium salt); 3-O-sulfo-alpha-D-C24:1-galactosylceramide (ammonium salt); ammonium (2S,3R,4S,5S,6R)-3,5-dihydroxy-2-(((2S,3R,E)-3-hydroxy-2-((Z)-tetracos-15-enamido)octadec-4-en-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl sulfate; Ammonium (2S,3R,4E)-3-hydroxy-2-[(15Z)-15-tetracosenoylamino]-4-octadecen-1-yl 3-O-sulfonato-α-D-threo-hexopyranoside. Grades: >99%. CAS No. 2260670-38-8. Molecular formula: C48H94N2O11S. Mole weight: 907.33.
C24-Ceramide
C24-Ceramide. Group: Biochemicals. Alternative Names: Lignoceric ceramide. Grades: Highly Purified. CAS No. 34435-05-7. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C42H83NO3. US Biological Life Sciences.
Worldwide
C24-Ceramide (d18:1/24:0)
C24-Ceramide (d18:1/24:0) is a sphingolipid that can be used for the lipid membranes composed. C24-Ceramide (d18:1/24:0) induces time-dependent changes in membrane properties. C24-Ceramide (d18:1/24:0) induces membrane reorganization [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 102917-80-6. Pack Sizes: 1 mg. Product ID: HY-134508A.
C24-Ceramide-d7
C24-Ceramide-d 7 is the deuterium labeled C24-Ceramide[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1840942-15-5. Pack Sizes: 1 mg; 5 mg; 500 μg. Product ID: HY-134508S.
C24 Ceramide (Lignoceric Ceramide)
Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of phospholipase C, appropriately named sphingomyelinase. Group: Biochemicals. Alternative Names: Lignoceric Ceramide. Grades: Highly Purified. CAS No. 34435-05-7. Pack Sizes: 5mg. US Biological Life Sciences.
C-2801X is originally isolated from Streptomyces heteromorphus. It is mainly resistant to Gram-positive bacteria and negative bacteria. Synonyms: C 2801X. CAS No. 56083-50-2. Molecular formula: C25H29N3O12S. Mole weight: 595.57.
C29 is a potential TLR2 inhibitor. C29 inhibited TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. Synonyms: TLR2-IN-C29; TLR2 IN C29; TLR2INC29; TLR2-inhibitor-C29; TLR2 inhibitor-C29; TLR2 inhibitor C29. CAS No. 363600-92-4. Molecular formula: C16H15NO4. Mole weight: 285.30.
C2 Adamantanyl Galactosylceramide (d18:1/2:0)
C2 Adamantanyl Galactosylceramide (d18:1/2:0) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively. Synonyms: [(2S,3R,4E)-2-[(1-Adamantyl)acetylamino]-3-hydroxy-4-octadecenyl]beta-D-galactopyranoside; N-(1-Adamantaneacetyl)-galactosylceramide; Adamantanyl Galactosyl(β) Ceramide; AdaGalCer(d18:1/2:0). Grades: ≥98%. CAS No. 574738-16-2. Molecular formula: C36H63NO8. Mole weight: 637.89.
C2 Adamantanyl Glucosylceramide (d18:1/2:0)
C2 Adamantanyl glucosylceramide (AdaGluCer) is a bioactive sphingolipid. It increases levels of glycosphingolipids in Vero cells at low concentrations (≤20 μM) but decreases them at high concentrations (≥40 μM). Pretreatment of microsomes with AdaGluCer increases production of adamantanyl lactosylceramide (AdaLacCer) and reduces synthesis of LacCer from exogenous GlcCer. AdaGluCer inhibits glucocerebrosidase activity in vitro in a pH-dependent manner. Synonyms: N-(1-Adamantaneacetyl) Glucosylceramide; Adamantanyl GluCer(d18:1/2:0); Adamantanyl Glucosylceramide (d18:1/2:0); AdaGluCer(d18:1/2:0). Grades: ≥98%. Molecular formula: C36H61NO8. Mole weight: 635.87.
Permanent murine cell lines of fast and slow skeletal myocyte derivation. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ug. US Biological Life Sciences.
Permanent murine cell lines of fast and slow skeletal myocyte derivation. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ug. US Biological Life Sciences.
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C2C12 Transfection Reagent
Transfection Reagent for C2C12 Monocyte Macrophage Cells. Optimized transfection protocol provided for transfection of siRNA, DNA, mRNA, and microRNA. Transfection Reagents. Transfection Enhancer. Complex Condenser. Uses: Transfection of DNA, RNA, protein and small molecules. Product ID: 6344.
Nevada, Texas, USA
C2,C8-Dimethyladenosine
C2,C8-Dimethyladenosine, a nucleoside derivative prevalently employed in the biomedical sector, assumes a critical function in the amalgamation of innovative pharmaceuticals for the purpose of combating diverse ailments. Its profound attributes render it a coveted asset for both researchers and pharmaceutical firms engaged in the exploration and advancement of medicinal remedies. Molecular formula: C12H17N5O4. Mole weight: 295.30.