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Cabotegravir Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,11aS)-N-(2,4-difluorobenzyl)-6-methoxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide. Molecular Formula: C20H19F2N3O5. Mole Weight: 419.13. Catalog: APB05052.
Cabotegravir Impurity 7
Cabotegravir Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-N-(2,4-difluorobenzyl)-2-(1-hydroxypropan-2-yl)-9-methoxy-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide. Molecular Formula: C20H19F2N3O5. Mole Weight: 419.13. Catalog: APB05053.
Cabotegravir Impurity 8
Cabotegravir Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,11aS)-N-(2,4-difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide. Molecular Formula: C19H17F2N3O5. Mole Weight: 405.11. Catalog: APB05051.
Cabotegravir Impurity 9
Cabotegravir Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-methoxy-6-(methoxycarbonyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-3-carboxylic acid. CAS No. 1335210-31-5. Molecular Formula: C11H11NO7. Mole Weight: 269.05. Catalog: APB1335210315.
Cabotegravir Metabolite M2
Cabotegravir Metabolite M2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3S,11aR)-N-(2,4-difluorobenzyl)-3-methyl-5,7-dioxo-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide. CAS No. 2170827-76-4. Molecular Formula: C25H27F2N3O10. Mole Weight: 567.17. Catalog: APB2170827764.
Cabotegravir sodium
Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 ( OAT1 / OAT3 ) inhibitor with IC 50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIV ADA , OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK-1265744 sodium; S/GSK1265744 sodium. CAS No. 1051375-13-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15592A.
Cabozantinib
Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Grades: >98%. CAS No. 849217-68-1. Molecular formula: C28H24FN3O5. Mole weight: 501.51.
Cabozantinib
Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET , with IC 50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT , RET , AXL , TIE2 , and FLT3 ( IC 50 =4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: XL184; BMS-907351. CAS No. 849217-68-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13016.
Cabozantinib
Cabozantinib. Uses: For analytical and research use. Group: Impurity standards. CAS No. 849217-68-1. Molecular Formula: C28H24FN3O5. Mole Weight: 501.51. Catalog: APB849217681.
Cabozantinib-d4 L-Malate Salt
Cabozantinib-d4 L-Malate Salt. Group: Biochemicals. Alternative Names: N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N'- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide-d4 (2S)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Cabozantinib Des-O-fluoroaniline
It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid; Cabozantinib Impurity 03. CAS No. 849217-77-2. Molecular formula: C22H20N2O6. Mole weight: 408.40.
Cabozantinib (free base)
Cabozantinib / XL184 / BMS-907351 is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Group: Fluorinated apis. Alternative Names: BMS-90735. CAS No. 849217-68-1. Molecular formula: C28H24FN3O5. Mole weight: 501.51. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide. Catalog: OFC849217681.
Cabozantinib, Free Base, 99+%
Cabozantinib, also known as XL184, is an orally bioavailable novel tysosine kinase inhibitor of c-MET and VEGF receptor 2 (VEGFR2). It inhibited MET and VEGFR2 with IC50 values of 1.3 nM and 35 pM, respectively. It also inhibited MET-activating kinase domain mutations Y1248H, D1246N, or K1262R with IC50 values of 3.8, 11.8, and 14.6 nM, respectively. It strongly inhibited several kinases that are implicated in tumor pathobiology including KIT, RET, AXL, TIE2, and FLT3 with IC50 values of 4.6, 5.2, 7, 14.3, and 11.3 nM, respectively. In cellular assays, cabozantinib inhibited phosphorylation of MET, VEGFR2, KIT, FLT3, and AXL with IC50 values of 7.8, 1.9, 5.0, 7.5, and 42 [micro]M, respectively. Cabozantinib inhibited tumor angiogenesis, tumor growth and metastasis in cancers with dysregulated MET and VEGFR signaling. Yakes F.M., et al "Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth." Mol. Cancer Ther. 10: 229 Group: Biochemicals. Alternative Names: BMS-907351; XL-184; Cometriq; N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide (2S)-2-Hydroxybutanedioic Acid. Grades: Highly Purified. CAS No. 849217-68-1. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences.
Worldwide
Cabozantinib Impurity 2
Cabozantinib Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1802168-46-2. Molecular Formula: C28H18D6FN3O5. Mole Weight: 507.55. Catalog: APB1802168462.
Cabozantinib impurity 21
Cabozantinib impurity 21. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(hydroxyamino)phenol. CAS No. 3505-87-1. Molecular Formula: C6H7NO2. Mole Weight: 125.13. Catalog: APB3505871.
Cabozantinib impurity 22
Cabozantinib impurity 22. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-fluoro-4-nitrosobenzene. CAS No. 352-15-8. Molecular Formula: C6H4FNO. Mole Weight: 125.1. Catalog: APB352158.
Cabozantinib impurity 23
Cabozantinib impurity 23. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(4-fluorophenyl)hydroxylamine. CAS No. 406-00-8. Molecular Formula: C6H6FNO. Mole Weight: 127.12. Catalog: APB406008.
Cabozantinib impurity 24
Cabozantinib impurity 24. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: dimethyl 2-(2-bromoethyl)malonate. Molecular Formula: C7H11BrO4. Mole Weight: 239.06. Catalog: APB04124.
Cabozantinib impurity 25
Cabozantinib impurity 25. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6,7-dimethoxyquinolin-4-ol. Molecular Formula: C11H11NO3. Mole Weight: 205.21. Catalog: APB04125.
Cabozantinib impurity 26
Cabozantinib impurity 26. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-nitrophenol. Molecular Formula: C6H5NO3. Mole Weight: 139.11. Catalog: APB04123.
Cabozantinib impurity 27
Cabozantinib impurity 27. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: cyclopropane-1,1-dicarboxylic acid. Molecular Formula: C5H6O4. Mole Weight: 130.1. Catalog: APB04122.
Cabozantinib impurity 28
Cabozantinib impurity 28. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1- ( (2-fluorophenyl) carbamoyl) cyclopropanecarboxylic acid. CAS No. 918642-61-2. Molecular Formula: C11H10FNO3. Mole Weight: 223.2. Catalog: APB918642612.
Cabozantinib impurity 29
Cabozantinib impurity 29. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6-chloro-1H-benzo[d][1,2,3]triazol-1-ol. Molecular Formula: C6H4ClN3O. Mole Weight: 169.57. Catalog: APB04121.
Cabozantinib Impurity 3
Cabozantinib Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 26198-19-6. Molecular Formula: C6H4ClN3O. Mole Weight: 169.57. Catalog: APB26198196.
Cabozantinib impurity 30
Cabozantinib impurity 30. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6,7-dimethoxy-4-(4-nitrophenoxy)quinoline. CAS No. 190728-24-6. Molecular Formula: C17H14N2O5. Mole Weight: 326.3. Catalog: APB190728246.
Cabozantinib impurity 31
Cabozantinib impurity 31. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-4-((6,7-dimethoxyquinolin-4-yl)oxy)-N-(pentan-2-ylidene)aniline. Molecular Formula: C22H24N2O3. Mole Weight: 364.44. Catalog: APB04120.
Cabozantinib impurity 32
Cabozantinib impurity 32. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N,N'-bis(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide. CAS No. 2439164-91-5. Molecular Formula: C39H34N4O8. Mole Weight: 686.71. Catalog: APB2439164915.
Cabozantinib impurity 33
Cabozantinib impurity 33. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N- (cyclohexa-1, 3-dien-1-yl) -N- (4- ( (1- (4, 5-dimethoxy-2- (methyleneamino) phenyl) vinyl) oxy) phenyl) cyclopropane-1, 1-dicarboxamide. Molecular Formula: C28H29N3O5. Mole Weight: 487.55. Catalog: APB04119.
Cabozantinib impurity 34
Cabozantinib impurity 34. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4- (4- (1- ( (4-fluorophenyl) carbamoyl) cyclopropanecarboxamido) phenoxy) -6, 7-dimethoxyquinoline 1-oxide. CAS No. 1621681-63-7. Molecular Formula: C28H24FN3O6. Mole Weight: 517.51. Catalog: APB1621681637.