A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
R-(-)-3-Quinuclidinol. Group: Biochemicals. Alternative Names: (R)-(-)-3-Hydroxyquinuclidine; (R)-(-)-1-Azabicyclo[2.2.2]octan-3-ol. Grades: Highly Purified. CAS No. 25333-42-0. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C7H13NO. US Biological Life Sciences.
Worldwide
R-(-)-3-Quinuclininol HCl
R-(-)-3-Quinuclininol HCl. Group: Biochemicals. Grades: Highly Purified. CAS No. 42437-96-7. Pack Sizes: 1g, 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
R406
R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling (EC(50) for degranulation=56-64 nM). The primary target for R406 is the spleen tyrosine kinase (Syk). R406 inhibited phosphorylation of Syk substrate linker for activation of T cells in mast cells and B-cell linker protein/SLP65 in B cells. R406 bound to the ATP binding pocket of Syk and inhibited its kinase activity as an ATP-competitive inhibitor (K(I)=30 nM). Furthermore, R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 is orally bioavailable, achieving exposures capable of inhibiting Syk-dependent IgE-mediated basophil activation. Collectively, the results show R406 potential for modulating Syk activity in human disease. Synonyms: R 406; R-406. CAS No. 841290-80-0. Molecular formula: C22H23FN6O5. Mole weight: 470.45.
R406 Benzenesulfonate
R406 is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Synonyms: R406; R 406; R-406. Grades: >98%. CAS No. 841290-81-1. Molecular formula: C28H29FN6O8S. Mole weight: 628.63.
R-4200
R-4200. Group: Polymers.
R 428 dihydrochloride
R 428 dihydrochloride is a potent and selective inhibitor of Axl receptor tyrosine kinases (IC50 = 14 nM). R428 inhibits Axl kinase and Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Synonyms: R 428 dihydrochloride; R428 dihydrochloride; R-428 dihydrochloride; 1-(6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine dihydrochloride; Thiocolchicoside dihydrochloride. Grades: 99%. CAS No. 2108833-51-6. Molecular formula: C30H34N8.2HCl. Mole weight: 579.57.
5g Pack Size. Group: Amino Acids, Building Blocks, Organics. Formula: C10H11NO2. CAS No. 102029-44-7. Prepack ID 27204332-5g. Molecular Weight 177.2. See USA prepack pricing.
R)-4-Benzylthiazolidine-2-thione
1g Pack Size. Group: Building Blocks, Organics. Formula: C10H11NS2. CAS No. 110199-17-2. Prepack ID 90028106-1g. Molecular Weight 209.33. See USA prepack pricing.
R-5- (2- Benzene sulphonylethenyl) -3- (N-methylpyrrolidin-2-ylmethyl) -1H-indole. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
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R547
R547 is orally bioavailable diaminopyrimidine cyclin-dependent kinase inhibitor (CDKI) with potential antineoplastic activity. CDKI R547 selectively binds to and inhibits CDKs, especially CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1. The inhibition of CDKs results in cell cycle arrest, inhibition of tumor cell proliferation, and induction of apoptosis. Through CDK inhibition, this agent also reduces phosphorylation of the retinoblastoma (Rb) protein, thus preventing activation of transcription factor E2F and so further suppressing tumor cell proliferation. CDKs are ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and are frequently overexpressed in tumor cells. Synonyms: RO-4584820; RO4584820; RO 4584820. R 547; R547; R-547. Grades: >98%. CAS No. 741713-40-6. Molecular formula: C18H21F2N5O4S. Mole weight: 441.45.
R 568 is positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR), increasing the sensitivity to activation by extracellular Ca2+. It dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials. R-568 is used in research to explore novel actions of CaSR. Synonyms: R 568 hydrochloride; R568 hydrochloride; R-568 hydrochloride; 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride; 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine Hydrochloride (9CI); (R)-2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine Hydrochloride; KRN 568; NPS-R 568; Norcalcin; R 568; R 568 (Pharmaceutical); Tecalcet Hydrochloride. Grades: ≥99% by HPLC. CAS No. 177172-49-5. Molecular formula: C18H22ClNO.HCl. Mole weight: 340.29.
R 568 hydrochloride
R 568 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 177172-49-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
R 59-022. Group: Biochemicals. Grades: Purified. CAS No. 93076-89-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
R 59-022
R 59-022 is a diacylglycerol (DAG) kinase inhibitor (IC50 = 2.8 μM) without affecting phosphodiesterase or phosphatidylinositol kinase, and potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. R 59-022 also blocks vascular contraction induced by the thromboxane analog U-46619. At 10 μM, R 59-022 induces apoptosis in glioblastoma cells without being toxic to non-cancerous cells. Uses: Enzyme inhibitors. Synonyms: R59022; R-59022; R 59022; 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one; Diacylglycerol Kinase Inhibitor I. Grades: ≥98% by HPLC. CAS No. 93076-89-2. Molecular formula: C27H26FN3OS. Mole weight: 459.58.
R-59-949
R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) expressed in vascular smooth muscle cells. It inhibits inducible nitric oxide production in vascular smooth muscle cells through decreasing transplasmalemmal L-arginine uptake. Synonyms: Diacylglycerol Kinase Inhibitor II; DKGI-II; R 59949; R 59 949. Grades: ≥98%. CAS No. 120166-69-0. Molecular formula: C28H25F2N3OS. Mole weight: 489.6.
R-5-Bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
R66905
R66905, also known as saperconazole, is a broad-spectrum antifungal triazole. Synonyms: Saperconazole; SPZ; R66905; R-66905; R 66905; 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; saperconazole. CAS No. 110588-57-3. Molecular formula: C35H38F2N8O4. Mole weight: 672.72.
R-7128 is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all HCV genotypes. It is a nucleoside polymerase inhibitor (NPI) and is able to inhibit the RNA synthesis of HCV in vitro. Synonyms: Mericitabine; PSI 6130 diisobutyrate; RG7128; RG-7128; RG 7128; R-7128; R7128; R 7128; PSI 6130 diisobutyrate; 3',5'-Diisobutyryl PSI 6130; Mericitabine. Grades: >98%. CAS No. 940908-79-2. Molecular formula: C18H26FN3O6. Mole weight: 399.41.
R715
R715 is a selective bradykinin B1 receptor antagonist. R715 significantly attenuates the hyperalgesic effect developed in Streptozotocin(HY-13753)-diabetic mice [1]. Uses: Scientific research. Group: Peptides. CAS No. 185052-09-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-103290.
R 715
R 715 is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49),without activity on B2 receptors. Uses: Bradykinin receptor antagonists. Synonyms: R 715; R715; R-715. Grades: >98%. CAS No. 185052-09-9. Molecular formula: C57H81N13O12. Mole weight: 1140.35.
R 715
R 715. Group: Biochemicals. Grades: Purified. CAS No. 185052-09-9. Pack Sizes: 1mg. US Biological Life Sciences.
R788 sodium salt hydrate, a methylene phosphate prodrug of the active metabolite R406, is a potent Syk inhibitor. It can be rapidly converted to R406 in vivo. It effectively inhibits BCR signaling in vivo, resulting in reduced proliferation and survival of the malignant B cells and significantly prolonged survival of the treated animals. Synonyms: Fostamatinib disodium hexahydrate; R788 disodium hexahydrate; R 788 disodium hexahydrate; R-788 disodium hexahydrate. Grades: >98%. CAS No. 914295-16-2. Molecular formula: C23H24FN6Na2O9P. Mole weight: 624.42.
R 84852
R 84852. Uses: For analytical and research use. Group: Impurity standards. CAS No. 152542-03-5. Pack Sizes: 5MG. IUPAC Name: 3-[2-[4-(4-fluoro-2-hydroxybenzoyl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one. Molecular formula: C23H28FN3O4. Mole weight: 429.48. Catalog: APS152542035. SMILES: CC1=C(CCN2CCC(CC2)C(=O)c3ccc(F)cc3O)C(=O)N4CCCC(O)C4=N1. Format: Neat. Shipping: Room Temperature.
R-8507
R-8507 is an antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β in an ELISA using A549 lung epithelial cells. Synonyms: 1-(4-chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline. Grades: ≥98%. CAS No. 338773-13-0. Molecular formula: C16H8ClF3N4. Mole weight: 348.7.
R 892
R 892 is a selective, highly potent, and metabolically stable bradykinin B1 receptor antagonist (ID50= 2.8 and > 600 nM at B1 and B2 receptors respectively). It may be useful for the assessment of the physiological and pathological roles of kinin B1 receptors. R 892 exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Synonyms: R 892; R892; R-892; (1Z, 4Z, 6S, 7Z, 9S, 10Z, 12R, 13Z, 15S) -1- ( (S) -1- ( (S) -1- ( (S) -2- ( (Z) - ( (S) -6-amino-1-hydroxy-2- ( (Z) - (1-hydroxyethylidene) amino) hexylidene) amino) -5-guanidinopentanoyl) pyrrolidine-2-carbonyl) pyrrolidin-2-yl) -6-benzyl-15- ( (S) -sec-butyl) -1, 4, 7, 10, 13-pentahydroxy-9- (hy. Grades: >98%. CAS No. 229030-05-1. Molecular formula: C58H83N13O12. Mole weight: 1154.37.
R 892
R 892. Group: Biochemicals. Grades: Purified. CAS No. 229030-05-1. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
R8-T198wt
R8-T198wt. Group: Biochemicals. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
R8-T198wt
R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase. It inhibits Pim-1 phosphorylation of p27Kip1 and Bad, and induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt is possible that this peptide can also inhibit other kinases of the Pim family, such as Pim-2 and Pim-3, because not only Pim-1 but also Pim-2 and Pim-3 can directly phosphorylate p27Kip1 at the Thr198 residue. Synonyms: H-Gly-Gly-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Cys-Lys-Lys-Pro-Gly-Leu-Arg-Arg-Arg-Gln-Thr-OH. Grades: >95%. CAS No. 2305815-72-7. Molecular formula: C111H211N59O26S. Mole weight: 2820.33.
R916562
R916562, a diaminotriazole compound, is a potential and selective Axl/VEGF-R2 dual inhibitor with IC50s of 136 and 24 nM, respectively. R916562 showed activity comparable to the clinically approved tyrosine kinase inhibitor Sunitinib in mouse tumor xenograft models and the corneal micropocket angiogenesis model. Synonyms: R916562; R 916562; R-916562. CAS No. 1037798-41-6. Molecular formula: C26H30ClN9S. Mole weight: 536.09.
R-932348
A dual JAK/SYK inhibitor that can be used to treat diseases and disorders of the eye. Synonyms: R-932348; R 932348; R932348; Propanamide, N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]-. CAS No. 916742-11-5. Molecular formula: C23H22FN5O4S. Mole weight: 483.52.
R-96544
R-96544 is an orally active 5-HT 2A receptor antagonist. R-96544 can inhibit platelet aggregation in vitro [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 167144-80-1. Pack Sizes: 5 mg. Product ID: HY-103136.
R-96544 hydrochloride
R-96544 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 167144-80-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
R9-Tat is the arginine-substituted analogue for the HIV Tat protein (48-60). Similar to Tat (48-60), R9-Tat is internalized by macrophages and translocated to the nucleus and cytoplasm. Additionally, R9-Tat is highly efficient in intracellular protein transport and acts as a protein carrier for carbonic anhydrase to enter cells. Synonyms: H-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Pro-Pro-Gln-OH; glycyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-prolyl-L-prolyl-L-glutamine. Grades: >95% by HPLC. Molecular formula: C71H135N41O15. Mole weight: 1803.13.
RA190
RA190, a bis-benzylidine piperidon, is a novel potent and selective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1. RA190 stabilized targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially killed HPV-transformed cells. Synonyms: (3Z,5Z)-1-[(2S)-2-amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one;hydrochloride; 3,5-bis(3,4-dichlorobenzylidene)-1-(S-2-amino-3-phenyl)-piperidin-4-one, HCl; RA190. CAS No. 1617495-03-0. Molecular formula: C28H23Cl5N2O2. Mole weight: 596.76.
RA 839 is a selective inhibitor of the Keap1/Nrf2 interaction (Kd=6 uM) and a useful tool compound to study the biology of Nrf2. It binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM. RA 839 suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Synonyms: (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid; RA-839; RA 839; RA839. Grades: ≥98% by HPLC. CAS No. 1832713-02-6. Molecular formula: C25H28N2O4S. Mole weight: 452.57.
Rabacfosadine (GS-9219), a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-9219; VDC-1101. CAS No. 859209-74-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13640.
Rabdophyllin g. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 10-deepoxy-13-deoxy-5-hydroxy-8-(acetyloxy)-(5-alpha)-enmei;isodonoiol;rabdosinc;RABDOPHYLLIN G. Product Category: Heterocyclic Organic Compound. CAS No. 82460-75-1. Molecular formula: C22H30O7. Mole weight: 406.47. Purity: 0.96. IUPACName: Isodonoiol. Canonical SMILES: CC(=O)OCC12C(CCC(C1CO)(C)C)OC(=O)C34C2C(CC(C3)C(=C)C4=O)O. Density: 1.3g/cm³. Product ID: ACM82460751. Alfa Chemistry ISO 9001:2015 Certified. Categories: Rabdosin C.
Rabdosiin
Rabdosiin is a tetramer of caffeic acid isolated from the stem of Ocimum sanctum. Rabdosiin possess anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 263397-69-9. Molecular formula: C36H30O16. Mole weight: 718.61. Purity: 0.9955. Canonical SMILES: OC1=C(O)C=CC(C[C@@H](C(O)=O)OC([C@@H]2[C@@H](C3=CC(O)=C(O)C=C3)C4=CC(O)=C(O)C=C4C=C2C(O[C@@H](C(O)=O)CC5=CC(O)=C(O)C=C5)=O)=O)=C1. Product ID: ACM263397699. Alfa Chemistry ISO 9001:2015 Certified.
Rabelomycin
Rabelomycin is originally isolated from Str.olivaceus. Rabelomycin only works against gram-positive bacteria. Synonyms: ZINC4654730. Molecular formula: C19H14O6. Mole weight: 338.31.
Rabenosyn-5 (541-552)
Rabenosyn-5 (541-552) is a peptide corresponding to residues 541-552 of Rabenosyn-5. Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. Synonyms: RAB effector RBSN (541-552); Zinc finger FYVE domain-containing protein 20 (541-552).
Rabeprazole
1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C18H21N3O3S. CAS No. 117976-89-3. Prepack ID 51732920-1g. Molecular Weight 359.44. See USA prepack pricing.
Rabeprazole
Rabeprazole, a partially reversible inhibitor of gastric proton pump, could be used in the treatment of sorts of gastrointestinal disease especially peptic ulcer. It was already completed a Phase III trial for Gastro-oesophageal reflux disease in Japan. Uses: Rabeprazole is a partially reversible inhibitor of gastric proton pump and could be used in the treatment of sorts of gastrointestinal disease especially peptic ulcer. Synonyms: Rabeprazole. Grades: >98%. CAS No. 117976-89-3. Molecular formula: C18H21N3O3S. Mole weight: 359.45.
Rabeprazole
Rabeprazole (LY307640) is a second-generation proton pump inhibitor ( PPI ) that irreversibly inactivates gastric H + /K + -ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase ( UNH ) inhibitor with an IC 50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY307640. CAS No. 117976-89-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B0656.
Rabeprazole-d3 Sodium Salt
Labeled Rabeprazole. A partially reversible gastric proton pump inhibitor. Group: Biochemicals. Alternative Names: 2- [ [ [ (4- (3-Methoxy-d3) propoxy) -3-methyl-2-pyridinyl] methyl] sulfinyl] -1H-benzimidazole Sodium Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Rabeprazole-d3 Sulfide
A labeled metabolite of Rabeprazole. Group: Biochemicals. Alternative Names: 2-[[[3-Methyl-4-(3-(methoxy-d3)propoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole; 2-{[4-(3-(Methoxy-d3)propoxy)-3-methylpyridine-2-yl]-methythio}-1H-benzimidazole; H 295/43-d3; Rabeprazole-d3 Thioether. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Rabeprazole-d4
Rabeprazole-d4. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences.
Worldwide
Rabeprazole-d4
Rabeprazole-d 4 is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: LY307640-d4. CAS No. 934295-48-4. Pack Sizes: 1 mg. Product ID: HY-B0656S.
Rabeprazole EP Impurity C
An impurity of Rabeprazole. A degradation product formed in stressed tablets of Rabeprazole sodium. Synonyms: 1-(1H-Benzimidazol-2-yl)-1,4-dihydro-3-methyl-4-oxo-2-pyridinecarboxylic Acid. Grades: 95%. CAS No. 1163685-30-0. Molecular formula: C14H11N3O3. Mole weight: 269.25.
Rabeprazole EP Impurity E (Lansoprazole Impurity 12)
Rabeprazole EP Impurity E (Lansoprazole Impurity 12). Uses: For analytical and research use. Group: Impurity standards. CAS No. 102804-77-3. Molecular formula: C15H15N3O2S. Mole weight: 301.36. Catalog: APB102804773.
Rabeprazole EP Impurity G
Rabeprazole EP Impurity G. Uses: For analytical and research use. Group: Impurity standards. CAS No. 102804-82-0. Molecular formula: C15H15N3OS. Mole weight: 285.37. Catalog: APB102804820.