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| Product | Description | |
|---|---|---|
| KU 0058948 hydrochloride | KU 0058948 hydrochloride is a potent poly ADP-ribose polymeras (PARP) inhibitor (IC50: 3.4 nM for PARP1). In vitro, KU-0058948 activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells and induces cell cycle arrest and apoptosis of primary myeloid leukemic cells thus KU-0058948 can be potentially used to treat myeloid leukemia and myelodysplastic syndromes. Uses: Potential treatment of myeloid leukemia and myelodysplastic syndromes. Synonyms: KU 0058948 hydrochloride; KU0058948 hydrochloride; KU-0058948 hydrochloride; 4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one hydrochloride. Grades: 99%. Molecular formula: C21H21FN4O2.HCl. Mole weight: 416.88. |  |
| KU 0060648 | Dual PI 3-K and DNA-PK inhibitor (IC50 values are <0.1, 0.5, 4 and 19 nM for PI 3-Kdelta, PI 3-Kbeta, PI 3-Kalpha and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology- directed repair (HDR) efficiency, and attenuates nonhomologous end-joining (NHEJ). Group: Biochemicals. Alternative Names: 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-o xo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piper azineacetamide. Grades: Highly Purified. CAS No. 881375-00-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 582.71. US Biological Life Sciences. |  Worldwide |
| KU-0060648 | KU-0060648 is a dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3Kα (IC50=4 nM), PI3Kβ (IC50=0.5 nM), PI3Kδ (IC50=0.1 nM) less inhibition of PI3Kγ with IC50 of 0.59 μM. Synonyms: KU0060648; KU 0060648; N-[4-(2-Morpholino-4-oxo-4H-1-benzopyran-8-yl)dibenzothiophene-1-yl]-4-ethylpiperazine-1-acetamide. Grades: >98%. CAS No. 881375-00-4. Molecular formula: C33H34N4O4S. Mole weight: 582.71. | |
| KU-0060648 | KU-0060648 is a dual inhibitor of PI3K and DNA-PK with IC 50 s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 881375-00-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13431. |  |
| Ku-0063794 | KU-0063794 is an inhibitor of both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3-kinases) at 1000-fold higher concentrations. KU-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. It also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). It does not affect Thr308 phosphorylation in fibroblasts lacking essential mTORC2 subunits. KU-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. KU-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated. Uses: Differentiation. Synonyms: KU0063794; KU-0063794; KU 0063794; Ku0063794; Ku 0063794; Ku-0063794; KU63794; KU 63794; KU-63794; [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol. Grades: 0.98. CAS No. 938440-64-3. Molecular formula: C25H31N5O4. Mole weight: 465.554. | |
| KU-0063794 | KU-0063794 is a potent and specific mTOR inhibitor, inhibiting both the mTORC1 and mTORC2 complexes with IC 50 s of 10 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 938440-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50710. | |
| KU14R | KU14R. Group: Biochemicals. Grades: Purified. CAS No. 189224-48-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KU14R | KU14R is an antagonist of the atypical imidazoline binding site (putative I3 receptor) in isolated pancreatic islet beta cells. Synonyms: KU14R; KU-14R; KU 14R; 2-(2-ethyl-3H-1-benzofuran-2-yl)-1H-imidazole 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-2-imidazole KU 14R KU-14R KU14R. Grades: >99 %. CAS No. 189224-48-4. Molecular formula: C13H14N2O. Mole weight: 214.26. | |
| KU-2285 | KU-2285 is a potent hypoxic cell radiosensitizer. At less than 100 mg/kg, KU-2285 sensitized SCCVII tumors more than MISO and SR-2508 by fractionated irradiation. KU-2285 entered clinical trials in late 1990s. Synonyms: KU2285; KU 2285; NSC 635446; alpha,alpha-Difluoro-N-(2-hydroxyethyl)-2-nitro-1H-imidazole-1-propionamide. CAS No. 121077-11-0. Molecular formula: C8H10F2N4O4. Mole weight: 264.19. | |
| KU-55933 | KU-55933 is an ATM inhibitor, which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU-55933 treatment during serum starvation triggers apoptosis in these cancer cells. Research results suggest that KU-55933 may be a novel chemotherapeutic agent targeting cancer resistant to traditional chemotherapy or immunotherapy due to aberrant activation of Akt. Furthermore, KU-55933 completely abrogates rapamycin-induced feedback activation of Akt. Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone. Synonyms: KU 55933; KU-55933; KU55933. CAS No. 587871-26-9. Molecular formula: C21H17NO3S2. Mole weight: 395.49. | |
| KU59403 | KU59403 is a potent and selective ATM (Ataxia telangiectasia mutated) inhibitor with with potential anticancer activity. KU59403 was not cytotoxic to human cancer cell lines (SW620, LoVo, HCT116, and MDA-MB-231) per se but significantly increased the cytotoxicity of topoisomerase I and II poisons: camptothecin, etoposide, and doxorubicin. Chemo- and radiosensitization by ATM inhibition was not p53-dependent. Following administration to mice, KU59403 distributed to tissues and concentrations exceeding those required for in vitro activity were maintained for at least 4 hours in tumor xenografts. KU59403 significantly enhanced the antitumor activity of topoisomerase poisons in mice bearing human colon cancer xenografts (SW620 and HCT116) at doses that were nontoxic alone and well-tolerated in combination. Chemosensitization was both dose- and schedule-dependent. KU59403 represents a major advance in ATM inhibitor development, being the first compound to show good tissue distribution and significant chemosensitization in in vivo models of human cancer, without major toxicity. KU59403 provides the first proof-of-principle preclinical data to support the future clinical development of ATM inhibitors. Synonyms: KU59403; KU 59403; KU-59403. Grades: 98%. CAS No. 845932-30-1. Molecular formula: C29H32N4O4S2. Mole weight: 564.72. | |
| KU-60019 | KU-60019 is a potent and selective ATM inhibitor. KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells. Synonyms: KU60019; KU 60019; 2-((2R,6S)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide. Grades: 98%. CAS No. 925701-49-1. Molecular formula: C30H33N3O5S. Mole weight: 547.67. | |
| Ku70 | KU70 is a cell-penetrating peptide used to block the activity of KU70 antibody. Synonyms: H-Val-Pro-Met-Leu-Lys-Pro-Met-Leu-Lys-Glu-OH; L-valyl-L-prolyl-L-methionyl-L-leucyl-L-lysyl-L-prolyl-L-methionyl-L-leucyl-L-lysyl-L-glutamic acid. Grades: >98%. Molecular formula: C54H96N12O13S2. Mole weight: 1185.55. | |
| Kudzu Extract | Kudzu root extract is extracted from the plant in the genus pueraria in the pea family Fabaceae, subfamily faboideae. In traditional Chinese medicine, kudzu root extract puerarin is used in prescriptions for the treatment of thirst, headache, and stiff neck with pain due to high blood pressure. Kudzu root extract, also known as radix puerariae extract, contains a variety of phytochemicals, which are potent antioxidant compounds found naturally in plants, that help to prevent and treat human disease. Group: Others. Mole weight: 416.38. Kudzu Extract; Pueraria Edulis Pampan. Cat No: EXTC-013. |  |
| Kudzu Root Extract (Standard) | Kudzu root has been known for centuries in traditional Chinese medicine as ge-gen. The first written mention of the plant as a medicine is in the ancient herbal text of Shen Nong (about A.D.100). In traditional Chinese medicine, kudzu root is used in prescriptions for the treatment of thirst, headache, and stiff neck with pain due to high blood pressure. It is also recommended for allergies, migraine headaches, inadequate measles eruptions in children, and diarrhea It is also used in modern Chinese medicine as a treatment for angina pectoris. Applications: Kudzu root extract is used as remedy for diaphoretic,antispasmodic,muscle relaxant,antipyretic.kudzu root extract is also used for fevers caused by heat in colds and influenza and for stiff neck and shoulders. Group: Others. CAS No. Puerarin: 3681-99-0Genistein: 446-72-0Daidzin: 552-66-9Daidzein: 486-66-8. Purity: 40.0% Isoflavones UV/HPLC. Mole weight: Puerarin: 416.37Genistein: 270.23Daidzin: 416.38Daidzein: 254.23. Kudzu Root Extract (Standard); Puerarin: 3681-99-0Genistein: 446-72-0Daidzin: 552-66-9Daidzein: 486-66-8; Puerarin: C21H20O9Genistein: C15H10O5Daidzin: C21H20O9Daidzein: C10H15O4. Cat No: EXTW-008. | |
| Kukoamine A | Kukoamine A. Group: Biochemicals. Grades: Plant Grade. CAS No. 75288-96-9. Pack Sizes: 10mg. Molecular Formula: C28H42N4O6, Molecular Weight: 530.66. US Biological Life Sciences. | Worldwide |
| Kukoamine B | Kukoamine B. Group: Biochemicals. Grades: Plant Grade. CAS No. 164991-67-7. Pack Sizes: 10mg. Molecular Formula: C28H42N4O6, Molecular Weight: 530.66. US Biological Life Sciences. | Worldwide |
| KukoaMine B Impurity 4 | KukoaMine B Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C26H30N4O4. Mole Weight: 462.55. Catalog: APB12259. |  |
| KukoaMine Impurity 1 | KukoaMine Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C26H28O4. Mole Weight: 404.51. Catalog: APB12258. | |
| KukoaMine Impurity 2 | KukoaMine Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C66H74N4O9. Mole Weight: 1067.34. Catalog: APB12257. | |
| KukoaMine Impurity 3 | KukoaMine Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C64H70N4O8. Mole Weight: 1023.28. Catalog: APB12260. | |
| Kumbicin C | Kumbicin C is a bis-indolyl benzenoid fungal metabolite produced by A. kumbius FRR6049. Kumbicin C was found to inhibit the growth of mouse myeloma cells (IC50 = 0.74 μg/mL) and the Gram-positive bacterium Bacillus subtilis (MIC = 1.6 μg/mL). Synonyms: 5,8-di-1H-indol-3-yl-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-ol. Grades: ≥95%. CAS No. 1878151-58-6. Molecular formula: C28H24N2O3. Mole weight: 436.50. | |
| Kumquat Base | Kumquat Base. CAS No. MIXTURE. VIGON Item # 504913. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers. |  America & Internationally |
| Kunitz-type serine protease inhibitor 1 | Kunitz-type serine protease inhibitor 1 is a Kunitz protease inhibitor isolated from Xanthosoma sagittifolium. It has activity against gram-negative bacteria. Synonyms: Pro-Val-Val-Asp-Thr-Thr-Gly-Asn-Asn-Pro-Leu-Gln-Gln-Gln-Glu-Glu-Tyr-Tyr-Val. Grades: 96.4%. Molecular formula: C96H144N24O35. Mole weight: 2194.34. | |
| kunzeaol synthase | Isolated from the root of the plant Thapsia garganica. The enzyme also produces germacrene D, bicyclogermacrene and traces of other sesquiterpenoids. See EC 4.2.3.77, (+)-germacrene D synthase and EC 4.2.3.100, bicyclogermacrene synthase. Group: Enzymes. Synonyms: TgTPS2 (gene name). Enzyme Commission Number: EC 4.2.3.143. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5157; kunzeaol synthase; EC 4.2.3.143; TgTPS2 (gene name). Cat No: EXWM-5157. | |
| Kurarinone | Kurarinone. Group: Biochemicals. CAS No. 34981-26-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kurarinone | Kurarinone is an orally active flavonoid isolated from matrine that inhibits the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting cell differentiation of Th1 and Th17. Kurarinone has antitumor and anti-inflammatory activity [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 34981-26-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2279. | |
| Kurarinone, 2'-O-methyl- | Kurarinone, 2'-O-methyl-. Group: Biochemicals. Grades: Plant Grade. CAS No. 270249-38-2. Pack Sizes: 5mg. Molecular Formula: C27H32O6, Molecular Weight: 452.55. US Biological Life Sciences. | Worldwide |
| Kurasoin A | It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin A has the effect of inhibiting the protein fannicyl transferase. Synonyms: (+)-Kurasoin A; (S)-3-Hydroxy-4-(4-hydroxyphenyl)-1-phenyl-2-butanone. CAS No. 182232-62-8. Molecular formula: C16H16O3. Mole weight: 256.30. | |
| Kurasoin B | It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin B has the effect of inhibiting the protein fannicyl transferase. Synonyms: (+)-Kurasoin B. Molecular formula: C18H17NO2. Mole weight: 279.33. | |
| Kuromanin chloride | Kuromanin chloride is a natural compound found in Amelanchier spicata, Acer paxii. It is a scavenger of peroxynitrite and that exert a protective effect against endothelial dysfunction and vascular failure induced by peroxynitrite. Uses: Antioxidative. Synonyms: Kuromanine; Chrysontemin; Cyanidin-3-glucoside chloride. Grades: >98%. CAS No. 7084-24-4. Molecular formula: C21H21O11 Cl. Mole weight: 484.85. | |
| Kuromanin Chloride | Cyanidin-3-glucoside chloride. CAS No. 7084-24-4. Product ID: 3-02461. Molecular formula: C21H21ClO11. Mole weight: 484.84. |  |
| KUS121 | KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1357164-52-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-138233. | |
| Kushenol A | Kushenol A. Group: Biochemicals. Grades: Plant Grade. CAS No. 99217-63-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kushenol F (Sophoraflavanone G) | Kushenol F (Sophoraflavanone G). Group: Biochemicals. Alternative Names: 2?,4?,5,7-Tetrahydroxy-6-lavandulylflavanone; Norkurarinone;34981-24-3. Grades: Plant Grade. CAS No. 97938-30-2. Pack Sizes: 10mg. Molecular Formula: C25H28O6, Molecular Weight: 424.485999999999. US Biological Life Sciences. | Worldwide |
| Kushenol I | Kushenol I. Group: Biochemicals. Grades: Plant Grade. CAS No. 99119-69-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kushenol I | Kushenol I is a compound of the flavonoid class found in the Sophora flavescens Ait. Kushenol I is a GABAA receptor modulator and a Sodium-dependent glucose cotransporter 2(SGLT2) inhibitor. Synonyms: NSC 668937. Grades: >98%. CAS No. 99119-69-4. Molecular formula: C26H30O7. Mole weight: 454.5. | |
| Kushenol K | Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM). Kushenol K also inhibits the activity of SGLT1 and SGLT2. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 101236-49-1. Molecular formula: C26H32O8. Mole weight: 472.53. Product ID: ACM101236491. Alfa Chemistry ISO 9001:2015 Certified. |  |
| KuWal151 | KuWal151 is a potent and selective CLK inhibitor with IC50 values of 28, 88 and 510 nM for CLK4, 1 and 2, respectively. It inhibits growth of a range of cancer cell lines at subnanomolar concentrations. Synonyms: 3-(3-Chlorophenyl)-6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one. Grades: ≥98% by HPLC. CAS No. 2341841-06-1. Molecular formula: C16H11ClN2O. Mole weight: 282.72. | |
| Kuwanon A | Kuwanon A, a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.), inhibits nitric oxide production (IC50 = 10.5 μM). Synonyms: 5,7-dihydroxy-2-(5-hydroxy-2,2-dimethylchromen-8-yl)-3-(3-methylbut-2-enyl)chromen-4-one. CAS No. 62949-77-3. Molecular formula: C25H24O6. Mole weight: 420.45. | |
| Kuwanon A | Kuwanon A. Group: Biochemicals. CAS No. 62949-77-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kuwanon E | Kuwanon E. Group: Biochemicals. CAS No. 68401-05-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kuwanon G | Kuwanon G. Group: Biochemicals. Grades: Highly Purified. CAS No. 75629-19-5. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C40H36O11. US Biological Life Sciences. | Worldwide |
| Kuwanon G | Kuwanon G is a flavonoid isolated from Morus alba, acts as a bombesin receptor antagonist, with potential antimicrobial activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: kuwanon G;8-[(1S)-6α-(2,4-Dihydroxybenzoyl)-5β-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1β-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;Albanin F;Moracenin B;NSC 356888. Product Category: Inhibitors. Appearance: Solid. CAS No. 75629-19-5. Molecular formula: C40H36O11. Mole weight: 692.71. Purity: 0.95. Canonical SMILES: O=C1C(C/C=C(C)\C)=C(C2=CC=C(O)C=C2O)OC3=C([C@H]4C=C(C)C[C@@H](C5=CC=C(O)C=C5O)[C@@H]4C(C6=CC=C(O)C=C6O)=O)C(O)=CC(O)=C13. Product ID: ACM75629195. Alfa Chemistry ISO 9001:2015 Certified. | |
| Kuwanon H | Kuwanon H. Group: Biochemicals. CAS No. 76472-87-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kuwanon K | Kuwanon K is a natural product that can be isolated from Morus Lhou [1]. Uses: Scientific research. Group: Natural products. CAS No. 88524-66-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N11463. | |
| Kv1.3 Channel blocker 42 | Kv1.3 Channel blocker 42 is a selective potassium channel blocker of Kv1.3 current (IC50 < 50 nM). Kv1.3 channel blocker is promisingly used for the treatment of obesity and insulin resistance. Synonyms: Kv1.3 Channel blocker 42; 2108780-57-8; E98959; 1-(7-(3-(4-fluorophenyl)butoxy)-2,4-dimethyl-6-(2-(piperidin-1-yl)ethoxy)benzo[d]oxazol-5-yl)ethanone Hydrochloride. Grades: 99%. CAS No. 2108780-57-8. Molecular formula: C28H35FN2O4.HCl. Mole weight: 519.05. | |
| Kv1.3 Control Antigen (Kcna3, Charybdotoxin- sensitive Voltage-dependent Potassium Channel, HLK3) | Kv1.3 Control Antigen (Kcna3, Charybdotoxin- sensitive Voltage-dependent Potassium Channel, HLK3). Group: Molecular Biology. Grades: Purified. Pack Sizes: 120ug. US Biological Life Sciences. | Worldwide |
| Kv2.1-IN-1 | Kv2.1-IN-1 (compound 80) is a potent inhibitor of Kv2.1, with the IC 50 value of 0.07 μM, selectivity >130 fold over other K + , Na + , and Ca 2+ ion channels [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2252448-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161104. | |
| Kw-2449 | KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 1000669-72-6. Molecular formula: C20H20N4O. Mole weight: 332.4. Purity: >99%. Product ID: ACM1000669726. Alfa Chemistry ISO 9001:2015 Certified. | |
| KW-2449 | KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias. Synonyms: KW2449; KW-2449; KW 2449. CAS No. 1000669-72-6. Molecular formula: C20H20N4O. Mole weight: 332.407. | |
| KW-2450 Tosylate salt | KW-2450 is insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) antagonist. KW-2450 can selectively bind to and inhibit the activities of IGF-1R and IR and this may lead to the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In Apr 2013, Phase-I/II for Breast cancer and Phase-I for Solid tumours were discontinued in USA. Uses: Breast cancer; solid tumours. Synonyms: KW-2450 Tosylate salt; KW 2450 Tosylate salt; KW2450 Tosylate salt; (E)-N-(2-(2-(1H-indazol-3-yl)vinyl)-5-((4-(2-hydroxyacetyl)piperazin-1-yl)methyl)phenyl)-3-methylthiophene-2-carboxamide 4-methylbenzenesulfonate; 904899-25-8 (free base). Grades: 98%. CAS No. 1360433-93-7. Molecular formula: C35H37N5O6S2. Mole weight: 687.83. | |
| KW-2478 | KW-2478 is an inhibitor of Hsp90α , with an IC 50 of 3.8 nM, and has antitumor activity against various human hematological tumor cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 819812-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13468. | |
| KW-2478 | KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 antagonist KW-2478 appears to inhibit Hsp90, resulting in impaired signal transduction, inhibition of cell proliferation, and the induction of apoptosis in tumor cells. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses. Synonyms: 2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide; KW 2478; KW2478; QY50S617NM; 2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide; 819812-04-9 (free base); 2-[2-ethyl-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]carbonyl-3,5-bis(oxidanyl)phenyl]-~{N},~{N}-bis(2-methoxyethyl)ethanamide. Grades: >98%. CAS No. 819812-04-9. Molecular formula: C30H42N2O9. Mole weight: 574.66. | |
| KW 3902 | KW 3902. Group: Biochemicals. Grades: Purified. CAS No. 136199-02-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KW-3902 | KW-3902 is a selective adenosine A1 receptor antagonist under the development of Kyowa Hakko and Merck & Co. It displays 890-fold selectivity for rat A1 receptors over A2A receptors. (Ki value for adenosine A1 is 0.19 nM; 170 nM for adenosine A2A ). KW-3902 exhibits diuretic and renal protective effects in rats. Clinical trials for the treatment of Acute heart failure, Cognition disorders and Hypertension was discontinued. Uses: Acute heart failure; cognition disorders; hypertension. Synonyms: 1,3-dipropyl-8-(3-noradamantyl)xanthine, 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione, KW-3902; KW 3902; KW3902; Rolofylline. Grades: 98%. CAS No. 136199-02-5. Molecular formula: C20H28N4O2. Mole weight: 356.46. | |
| KW-8232 | KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 217813-15-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100304A. | |
| KW-8232 free base | KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 170365-25-0. Pack Sizes: 1 mg. Product ID: HY-100304. | |
| KWG 1342 | KWG 1342. Group: Biochemicals. Alternative Names: 4-(4-Chlorophenoxy)-2,2-dimethyl-4-(1H-1,2,4-triazol-1-yl)-1,3-butanediol. Grades: Highly Purified. CAS No. 72699-18-4. Pack Sizes: 2.5mg. Molecular Formula: C14H18ClN3O3, Molecular Weight: 311.76. US Biological Life Sciences. | Worldwide |
| KWG 1342 Sulfate Sodium Salt | KWG 1342 Sulfate Sodium Salt. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C14H17ClN3NaO6S, Molecular Weight: 413.81. US Biological Life Sciences. | Worldwide |
| KX1-004 | KX1-004 is an Src-protein tyrosine kinase inhibitor to reduce cisplatin ototoxicity while preserving its antitumor effect. KX1-004 has been used to protect the cochlea from hazardous noise. Synonyms: KX1-004; KX 1-004; KX1 004. Grades: 0.98. CAS No. 518058-84-9. Molecular formula: C16H13FN2O2. Mole weight: 284.29. | |
| KX1-141 | KX1-141 is an Src-protein tyrosine kinase inhibitor, which may reduce cisplatin ototoxicity while preserving its antitumor effect. Synonyms: KX-1-141; KX 1-141; 1H-Indole-2-carboxamide, 7-(3-ethoxyphenyl)-5-fluoro-N-[(3-fluorophenyl)methyl]-. Grades: 98%. CAS No. 1000706-00-2. Molecular formula: C24H20F2N2O2. Mole weight: 406.42. | |
| KX2-391 | KX2-391 is an orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind to the ATP-binding site, Src kinase inhibitor KX2-391 specifically binds to the peptide substrate binding site of Src kinase; inhibition of kinase activity may result in the inhibition of primary tumor growth and the suppression of metastasis. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation and metastasis. Uses: Enzyme inhibitors. Synonyms: KX01, KX-01, KX 01, KX2-391; KX-2-391; KX 2-391; KX2391; KX-2391; KX 2391; Tirbanibulin. CAS No. 897016-82-9. Molecular formula: C26H29N3O3. Mole weight: 431.53. | |
| KX2-391 dihydrochloride | KX2-391 2Hcl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Synonyms: KX2-391 dihydrochloride; 1038395-65-1; KX2-391 (dihydrochloride); Tirbanibulin (dihydrochloride); N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide;dihydrochloride. Grades: >98%. CAS No. 1038395-65-1. Molecular formula: C26H31Cl2N3O3. Mole weight: 504.45. | |
| KY02111 | KY02111. Group: Biochemicals. Alternative Names: KY 02111, KY-02111, CHEMBL3186128, HY-13815, S-7828. Grades: Highly Purified. CAS No. 1118807-13-8. Pack Sizes: 10mg, 50mg. Molecular Formula: C18 H17 ClN 2O3, Molecular Weight: 376.9. US Biological Life Sciences. | Worldwide |
| KY02111 | KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1118807-13-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13815. | |
| KY02111 | KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling. Synonyms: N-(6-chlorobenzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide. Grades: >98%. CAS No. 1118807-13-8. Molecular formula: C18H17ClN2O3S. Mole weight: 376.86. | |
| KY 02111 | KY 02111. Group: Biochemicals. Grades: Purified. CAS No. 1118807-13-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KY 05009 | KY 05009 is an inhibitor of Traf2- and Nck-Interacting Kinase (TNIK; Ki value 100 nM in ATP competitive assay) that attenuates TGF-β1-mediated Wnt and Smad signaling and epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma A549 cells. In addition, KY05009 inhibits TGF-β1-induced phosphorylation of JNK1/2, FAK, Src, and paxillin. Synonyms: KY 05009; KY05009; KY-05009; 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide; 2-anilino-5-[(4-methylbenzoyl)amino]-1,3-thiazole-4-carboxamide. Grades: 99%. CAS No. 1228280-29-2. Molecular formula: C18H16N4O2S. Mole weight: 352.41. | |
| KY-1044 | KY-1044 is a novel anti-inducible co-stimulator molecule (ICOS) subclass G1 kappa monoclonal antibody developed for the treatment of cancer. KY-1044 has a dual mechanism of action: stimulating immune cells which are fighting the tumor, while also killing a type of cell known as T regulatory cells (Tregs). Uses: Potential cancer therapy. Synonyms: KY-1044; KY1044; KY1044. | |
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