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| Product | Description | |
|---|---|---|
| LY 221068 | LY 221068 is a Lipoxygenase inhibitor originated by Eli Lilly. It is a potent antioxidant with antiinflammatory properties. But no development was reported for Rheumatic disorders in USA. Uses: Rheumatic disorders. Synonyms: LY 221068; LY-221068; LY221068; 5-((3,5-Bis(1,1,-dimethylethyl)-4-hydroxyphenyl)methylene)-3-(dimethylamino)-4-thiazolidinone. Grades: 98%. CAS No. 132392-39-3. Molecular formula: C20H30N2O2S. Mole weight: 362.54. |  |
| LY-221501 | LY-221501, a piperidine derivative, has been found to be a NMDA receptor antagonist. Synonyms: LY 221501; LY221501; LY-221501; Cis-4-(3-Carboxyprop-1-yl)piperidine-2-carboxylic acid; 145512-35-2; LY 221501; 4-Piperidinebutanoicacid, 2-carboxy-, (2R,4S)-; AC1L31HC. Grades: 98%. CAS No. 145512-35-2. Molecular formula: C10H17NO4. Mole weight: 215.25. | |
| LY2228820 | LY2228820 is a novel and potent p38MAPK inhibitor (the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively). Synonyms: Ralimetinib; LY2228820; LY 2228820; LY-2228820. Grades: >98%. CAS No. 862505-00-8. Molecular formula: C24H29FN6. Mole weight: 420.53. | |
| LY2228820 | LY2228820. Group: Biochemicals. Alternative Names: 5-[2-(1,1-Dimethylethyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine dimethanesulfonate. Grades: Highly Purified. CAS No. 862507-23-1. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H37FN6O6S2. US Biological Life Sciences. |  Worldwide |
| LY2228820 dimesylate | LY2228820 dimesylate is the salt form of LY2228820, a tri-substituted imidazole derivative and p38α and β MAPK inhibitor. LY2228820 inhibits tumor growth in various cancer models. Synonyms: Ralimetinib Mesylate; Ralimetinib dimesylate; 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine mesylate. Grades: >98%. CAS No. 862507-23-1. Molecular formula: C26H37FN6O6S2. Mole weight: 612.74. | |
| LY-223592 | LY-223592 is a bio-active chemical compound. It has antitumor activity. It was developed by Eli Lilly & Co. Uses: Ly-223592 has antitumor activity. Synonyms: LY 223592; LY223592; LY-223592. 2'-Deoxy-2',2'-difluoro-guanosine;Guanosine, 2'-deoxy-2',2'-difluoro-;2-Amino-9-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one;LY223592;2',2'-Difluorodeoxyguanosine. Grades: >98 %. CAS No. 103828-82-6. Molecular formula: C10H11F2N5O4. Mole weight: 303.22. | |
| Ly223982 | Heterocyclic Organic Compound. CAS No. 117423-74-2. Molecular formula: C30H30O7. Mole weight: 502.6. Appearance: A crystalline solid. Catalog: ACM117423742. |  |
| LY223982 | This active molecular is benzophenone dicarboxylic acid derivative which is a potent BLT1 receptor antagonist. It inhibits the binding of radiolabeled-LTB4 to isolated human neutrophils and IC50 value is 13.2 nM. LY223982 also inhibits the leukotriene B4 (LTB4)-induced aggregation of guinea human neutrophils. IC50 value is 100 nM. In Aug 1997, phase II for Psoriasis in USA was discontinued. Uses: Psoriasis. Synonyms: LY 223982; LY-223982; LY223982; CGS 23131; SKF 107324; CGS23131; SKF107324; CGS-23131; SKF-107324; 5-(3-Carboxybenzoyl)-2-((6-(4-methoxyphenyl)-5-hexenyl)oxy)benzenepropanoic acid. Grades: 98%. CAS No. 117423-74-2. Molecular formula: C30H30O7. Mole weight: 502.56. | |
| LY 225910 | LY 225910 is a CCK2 receptor antagonist with IC50 value of 9.3 nM. Synonyms: LY 225910; LY-225910; LY225910; 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline. Grades: ≥95%. CAS No. 133040-77-4. Molecular formula: C27H24BrN3O2. Mole weight: 502.41. | |
| LY 225910 | LY 225910 is a selective antagonist for cholecystokinin receptor ( CCK2 receptor ), which affects the excitatory response to morphine, and leads to morphine sensitization [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 133040-77-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101352. |  |
| LY 231617 | LY 231617 is an antioxidant. It can prevent ischaemia-induced neurodegeneration. LY 231617 is an anti-ischaemic and neuroprotective agent. Synonyms: LY 231617; LY231617; LY-231617; 2,6-bis(1,1-Dimethylethyl)-4-[(ethylamino)methyl]phenol hydrochloride. Grades: ≥98% by HPLC. CAS No. 141545-89-3. Molecular formula: C17H29NO.HCl. Mole weight: 299.88. | |
| LY 231617 | LY 231617. Group: Biochemicals. Grades: Purified. CAS No. 141545-89-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ly 233053 | Heterocyclic Organic Compound. Alternative Names: ACMC-20n1x8, AGN-PC-00Q2TU, SureCN1897297, SureCN2783482, (2R,4S)-4-(2H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid, (2S,4R)-4-(2H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid, 2-Piperidinecarboxylicacid, 4-(2H-tetrazol-5-ylmethyl)-, (2R,4S)-, CTK8G7320, 125546-04-5, 142923-40-8, 4-(2H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid. CAS No. 125546-04-5. Molecular formula: C8H13N5O2. Mole weight: C8H13N5O2. Purity: >99 %. IUPACName: 4-(2H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid. Density: 1.398g/cm³. Catalog: ACM125546045. | |
| LY 233053 | LY 233053 is an NMDA receptor antagonist with IC50 value of 7 nM. Synonyms: LY233053; LY-233053 LY 233053; (2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylic acid. Grades: ≥99% by HPLC. CAS No. 125546-04-5. Molecular formula: C8H13N5O2. Mole weight: 211.22. | |
| LY2334737 | LY2334737 is an orally available valproic acid ester of gemcitabine, which is a broad-spectrum antimetabolite with antineoplastic activity. It is an orally available prodrug of gemcitabine which is a nucleoside analog used as chemotherapy. It is hydrolyzed by carboxylesterase 2 (CES2) and releases gemcitabine systemically over a period of time consistent with formation rate-limited kinetics. It was less cytotoxic to a SK-OV-3 CES2 knockdown than parental cells. Uses: Ly2334737 is used as chemotherapy. it has antineoplastic activity. Synonyms: LY2334737; LY 2334737; LY-2334737; gemcitabine prodrug; 2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)cytidine;N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]-2-propylpentanamide. Grades: >98 %. CAS No. 892128-60-8. Molecular formula: C17H25F2N3O5. Mole weight: 389.39. | |
| LY 233536 | LY 233536 is a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist, but few detailed information has been published yet. Synonyms: LY 233536; LY-233536; LY233536; (3R-(3alpha,4aalpha,6beta,8aalpha))-decahydro-6-(1H-tetrazol-5-ylmethyl)- 3-Isoquinolinecarboxylic acid. Grades: 98%. CAS No. 136845-59-5. Molecular formula: C12H19N5O2. Mole weight: 265.32. | |
| LY 235959 | LY 235959 is a competitive N-Methyl-D-Aspartate Receptor antagonist originated by Eli Lilly. No development was reported for treatment of Movement disorders in USA. Research for treatment of Alzheimer's disease was discontinued. Uses: Alzheimer's disease;movement disorders. Synonyms: LY 235959; LY235959; LY-235959; (3S)-(3-alpha-4-alpha,alpha-6-beta-8-alpha,alpha)-Decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid;LY 235959. Grades: 98%. CAS No. 137433-06-8. Molecular formula: C11H20NO5P. Mole weight: 277.26. | |
| LY 2365109 hydrochloride | LY 2365109 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 868265-28-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY 2365109 hydrochloride | Cas No. 868265-28-5. | |
| LY 2389575 hydrochloride | LY 2389575 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 885104-09-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY 2389575 hydrochloride | LY 2389575 hydrochloride is a mGluR3 receptor antagonist with IC50 value of 190 nM. Synonyms: LY2389575; LY-2389575; LY 2389575; (3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride. Grades: ≥98% by HPLC. CAS No. 885104-09-6. Molecular formula: C15H15BrCl2N4.HCl. Mole weight: 438.58. | |
| LY2409881 | LY2409881 is a novel selective inhibitor of IKK2. It inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. It suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs. Synonyms: LY2409881; LY 2409881; LY-2409881. Grades: >98%. CAS No. 946518-61-2. Molecular formula: C24H29ClN6OS. Mole weight: 485.04. | |
| LY2409881 Trihydrochloride | LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases. Synonyms: LY2409881; LY 2409881; LY-2409881. Grades: >98%. CAS No. 946518-60-1. Molecular formula: C24H32Cl4N6OS. Mole weight: 594.43. | |
| LY 243670 | LY 243670 is a bio-active molecular, but detailed information were not published yet. Synonyms: LY 243670; LY-243670; LY243670. 1-(3-Hydroxy-3-cyclohexylpropyl)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidine. Grades: 98%. CAS No. 120938-72-9. Molecular formula: C22-H35-N-O2. Mole weight: 345.52. | |
| LY-2456302 | LY-2456302, also called as CERC-501, is a potent, highly selective and centrally-penetrant kappa opioid receptor antagonist (Ki = 0.807 nM) with favorable pharmacokinetic and pharmacodynamic properties to evaluate the role of KOR in preclinical models of alcoholism. Synonyms: 4-[4-[[(2S)-2-(3,5-dimethylphenyl)pyrrolidin-1-yl]methyl]phenoxy]-3-fluorobenzamide; 3-fluoro4-(4-((2-(3,5-dimethylphenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide; LY2456302; CERC-501; LY 2456302; CERC 501; LY-2456302; CERC501. CAS No. 1174130-61-0. Molecular formula: C26H27FN2O2. Mole weight: 418.5. | |
| LY2457546 | LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. Synonyms: LY 2457546; LY-2457546. CAS No. 908265-94-1. Molecular formula: C28H20F4N4O. Mole weight: 504.48. | |
| LY 245769 | LY 245769 is a leukotriene E4 (LTE4) inhibitor, and it can inhibit the oxidative degradation of LTE4 and N-acetyl-LTE4 in animal model. LY 245769, as one of the omega-trifluoro analogs of leukotrienes, will provide a new tool for interfering with the inactivation of leukotrienes in the omega-oxidation pathway. Synonyms: LY 245769; LY-245769; LY245769; R-(R*,S*-(E,Z)))-3-(1H-tetrazol-5-yl)-alpha-(14,14,14-trifluoro-1-((2-(1H-tetrazol-5-yl)ethyl)thio)-2,4-tetradecadienyl)-3-(1H-tetrazol-5-yl)-alpha-(14,14,14-trifluoro-1-((2-(1H-tetrazol-5-yl)ethyl)thio)-2,4-tetradecadienyl)-. Grades: 98%. CAS No. 127345-02-2. Molecular formula: C25H33F3N8OS. Mole weight: 550.65. | |
| LY 249933 | LY 249933 is a bio-active molecular under the development of Eli Lilly. It has positive inotropic activity as a cardioselective 1,4-dihydropyridine compound. Uses: Positive inotropic activity. Synonyms: LY 249933; LY249933; LY-249933. 1-phenylethyl 2,6-dimethyl-5-nitro-4-thieno[3,2-c]pyridin-3-yl-1,4-dihydropyridine-3-carboxylate. Grades: 98%. CAS No. 123250-77-1. Molecular formula: C23H21N3O4S. Mole weight: 435.50. | |
| LY-2510924 | LY-2510924 is an inhibitor of CXC chemokine receptor 4 (CXCR4). It has potential antineoplastic activity. It binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation upon subcutaneous administration, which may result in decreased tumor cell proliferation and migration. It plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types. Uses: Ly-2510924 has potential antineoplastic activity. it plays an important role in chemotaxis and angiogenesis. Synonyms: LY2510924; LY 2510924; Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2; Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2; L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7?1)-lactam; N(1)Phe-Tyr-Lys(iPr)-D-Arg-2Nal-Gly-D-Glu(1)-Lys(iPr)-NH2. Grades: 98%. CAS No. 1088715-84-7. Molecular formula: C62H88N14O10. Mole weight: 1189.47. | |
| LY2510924 acetate | Ly2510924 acetate is a potent and selective CXCR4 antagonist that prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM. It has potential antineoplastic activity. Synonyms: L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7?1)-lactam, acetate (1:1); LY 2510924 acetate; LY-2510924 acetate; N(1)Phe-Tyr-Lys(iPr)-D-Arg-2Nal-Gly-D-Glu(1)-Lys(iPr)-NH2 acetate. Grades: ≥95%. Molecular formula: C62H88N14O10.C2H4O2. Mole weight: 1249.53. | |
| LY 255262 | This bio-active molecular is a antibacterial agent with a pyrazolidinone structure. Uses: Antibacterial. Synonyms: LY 255262; LY255262; LY-255262. 2-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-6-cyano-3-oxo-2,7-dihydro-1H-pyrazolo[1,2-a]pyrazole-5-carboxylic acid. Grades: 98%. CAS No. 124986-45-4. Molecular formula: C14H13N7O5S. Mole weight: 391.36. | |
| LY255283 | This active molecular is a competitive leukotriene B4 receptor antagonist and IC50 value is about 100 nM. LY 255283 is selective for the BLT2 receptor, since IC50 values at the BLT1 receptor are >10 μM. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM. It also inhibits the binding of radiolabeled LTB4 to eosinophil membranes and IC50 value is 260 nM. LY255283 reduces airway obstruction in animal models of asthma. However, clinical trials for asthma had been discontinued. Uses: Asthma. Synonyms: LY 255283; LY255283; LY-255283; (1-(5-Ethyl-2-hydroxy-4-(6-methyl-6-(1H-tetrazol-5-yl)heptyloxy)phenyl)ethanone). Grades: 98%. CAS No. 117690-79-6. Molecular formula: C19H28N4O3. Mole weight: 360.45. | |
| LY 255283 | LY255283, a competitive leukotriene B4 receptor antagonist, is used in leukotriene receptor research along with other selective leukotriene receptor agonists and antagonist to identify and differentiate the physiological and cell signaling effects of the leukotriene B4 receptor on processes such as paclitaxel resistance in MCF-7/DOX breast cancer cells, monocyte-derived dendritic cell chemotaxis, and 5-lipoxygenase activity and interleukin-8 production in human neutrophils. LY255283 may be used to help verify that an observed process or cell event is leukotriene B4 receptor-dependent.Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years.1,2 The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100nM.3 LY255283 exhibits IC50 values of ~950nM and >10uM at human recombinant BLT2 and BLT1 receptors, respectively.4 LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10uM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260nM.1. Group: Biochemicals. Alternative Names: 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone. Grades: Highly Purified. CAS No. 117690-79-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C19H28N4O3, Molecular Weight: 360.5. US Biological Life Sciences. | Worldwide |
| LY-2562175 | LY2562175 is a potent and selective FXR agonist in vitro. It has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclinical species. It was developed by Eli Lilly and Company and in clinic phase 1 trials with no progress. Uses: Ly2562175 has robust lipid modulating properties, lowering ldl and triglycerides while raising hdl in preclinical species. Synonyms: LY2562175; LY 2562175; LY-2562175;6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid. Grades: >98%. CAS No. 1103500-20-4. Molecular formula: C28H27Cl2N3O4. Mole weight: 540.44. | |
| LY-256548 | LY-25648 is a leukotriene B4 antagonist. Synonyms: LY 25648; LY-25648; LY25648; Dihydro-3-methyl-5-(4-hydroxy-3,5-ditert-butylbenzylidene)thiazol-4(5H)-one;LY25648;5-(3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene-N-methyl-4-thiazolidinone;(5Z)-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-3-methyl-1,3-thiazolidin-4-one. Grades: >98%. CAS No. 107889-31-6. Molecular formula: C19H27NO2S. Mole weight: 333.49. | |
| LY 257883 | LY 257883, also known as PPPA, is a competitive NMDA receptor antagonist which displays moderate selectivity for NR2A-containing receptors. Ki values are 0.13μM for NR2A, 0.47μM for NR2B, 1.10μM for NR2C and 3.86 μM for NR2D. Related experiments show that the increase in potency on raising of the extracellular pH results largely from an increase in the antagonist association rate constant but also from a small decrease in the dissociation rate constant. These results suggest that the fully ionized forms of the LY 257883 act as the active antagonist species at NMDA receptors. Synonyms: LY 257883; LY-257883; LY257883; 4-(3-phosphonopropyl)piperidine-2-carboxylic acid,PPPA. Grades: 98%. CAS No. 118183-22-5. Molecular formula: C9H18NO5P. Mole weight: 251.22. | |
| LY2584702 | LY2584702 is an orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. Synonyms: LY-2584702; LY 2584702. CAS No. 1082949-67-4. Molecular formula: C21H19F4N7. Mole weight: 445.4256. | |
| LY-2584702 hydrochloride | The hydrochloride salt form of LY2584702 which is a selective ATP competitive inhibitor of p70 S6 kinase. LY2584702 is still under Phase I trial for evaluating its potential anti-tumor effect.IC50: 4 nM (LY2584702). Uses: The hydrochloride salt form of ly2584702 which is a selective atp competitive inhibitor of p70 s6 kinase. Synonyms: LY-2584702 (hydrochloride); LY 2584702 (hydrochloride); LY2584702 (hydrochloride); SCHEMBL312564; CS-3598; CS 3598; CS3598. Grades: 98%. CAS No. 1082948-81-9. Molecular formula: C21H20ClF4N7. Mole weight: 481.88. | |
| LY2584702 Tosylate | LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1. Synonyms: 4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine 4-methylbenzenesulfonate; LY2584702; LY 2584702; LY-2584702; LYS6K2. Grades: >98%. CAS No. 1082949-68-5. Molecular formula: C28H27F4N7O3S. Mole weight: 617.62. | |
| LY2603618 | LY2603618 is a potent and selective small molecule inhibitor of Chk1 protein kinase activity in vitro (IC50=7 nM) and the first selective Chk1 inhibitor to enter clinical cancer trials. Synonyms: LY-2603618; LY 2603618; Rabusertib. Grades: >98%. CAS No. 911222-45-2. Molecular formula: C18H22BrN5O3. Mole weight: 436.31. | |
| LY2606368 | LY2606368 is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase. Synonyms: LY-2606368; LY 2606368. Grades: >98%. CAS No. 1234015-52-1. Molecular formula: C18H19N7O2. Mole weight: 365.397. | |
| LY2606368 dihydrochloride | The dihydrochloride salt form of LY2606368 which also known as prexasertib, is an inhibitor of checkpoint kinase 1 and has potential effect in antineoplastic. It is still under Phase II clinical trial against breast cancer and some other sorts of cancers. Uses: The dihydrochloride salt form of ly2606368 which also known as prexasertib, is an inhibitor of checkpoint kinase 1 and has potential effect in antineoplastic. Synonyms: UNII-9RFT476U2L; 9RFT476U2L; LY2606368 (dihydrochloride); 1234015-54-3; HY-18174A; CS-3507; CS 3507; CS3507; LY2606368; LY 2606368; LY-2606368. Grades: 98%. CAS No. 1234015-54-3. Molecular formula: C18H21Cl2N7O2. Mole weight: 438.31. | |
| LY2608204 | LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. Uses: Enzyme activators. Synonyms: LY-2608204; LY 2608204; LY2608204. Grades: >98%. CAS No. 1234703-40-2. Molecular formula: C28H37N3O3S3. Mole weight: 559.81. | |
| LY 266097 hydrochloride | LY 266097 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 172895-39-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY 266097 hydrochloride | LY 266097 hydrochloride is a 5-HT2B receptor antagonist. It can attenuate amphetamine-induced locomotion in the rat. Synonyms: LY 266097 hydrochloride; LY266097 hydrochloride; LY-266097 hydrochloride; 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride. Grades: ≥99% by HPLC. CAS No. 172895-39-5. Molecular formula: C21H23ClN2O2.HCl. Mole weight: 407.33. | |
| LY 269415 | LY 269415 is a 5-Lipoxygenase inhibitor originated by Eli Lilly. It is a potent antioxidant with antiinflammatory properties in vitro. But no development was reported for Rheumatic disorders in USA. Uses: Rheumatic disorders. Synonyms: LY 269415; LY269415; LY-269415. 5-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-3-(methylamino)-4-Thiazolidinone. Grades: 98%. CAS No. 132392-65-5. Molecular formula: C19H28N2O2S. Mole weight: 348.51. | |
| LY 272015 hydrochloride | LY 272015 hydrochloride is a selective 5-HT2B receptor antagonist. Synonyms: LY 272015 hydrochloride; LY272015 hydrochloride; LY-272015 hydrochloride; 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride. Grades: ≥99% by HPLC. CAS No. 172895-15-7. Molecular formula: C21H24N2O2.HCl. Mole weight: 372.89. | |
| LY-272015 hydrochloride | LY-272015 hydrochloride is an orally active, specific 5-HT 2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 172895-15-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100851A. | |
| LY 274614 | LY 274614 is a competitive Glutamate receptor antagonist originated by Eli Lilly. It is a promising therapeutic agent for conditions where glutamate plays a role in the pathology of neuronal degeneration. But no development was reported for the treatment of Alzheimer's disease, Epilepsy, Huntington's disease, Neuroprotection and Parkinson's disease yet. Uses: Alzheimer's disease; epilepsy; huntington's disease; neuroprotection; parkinson's disease. Synonyms: LY 274614; LY 274614; LY 274614. (3alpha,4aalpha,6beta,8aalpha)-decahydro-6-(phosphonomethyl)- 3-Isoquinolinecarboxylic acid. Grades: 98%. CAS No. 136109-04-1. Molecular formula: C11H20NO5P. Mole weight: 277.26. | |
| LY2784544 | LY2784544 is a potent and selective JAK2 inhibitor (IC50 = 3 nM), and exhibits less potency against JAK3 (IC50 =48 nM). LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50 = 20 and 55 nM, respectively). It reduces JAK2V617F tumor cell burden with no effect on erythroid progenitor cells. Synonyms: Gandotinib; LY-2784544; 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine. Grades: >98%. CAS No. 1229236-86-5. Molecular formula: C23H25ClFN7O. Mole weight: 469.949. | |
| LY 278584 | LY 278584 is a 5-HT3-receptor antagonist and no detailed information has been published yet. Synonyms: LY 278584; LY-278584; LY278584. 1-methyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]indazole-3-carboxamide. Grades: 98%. CAS No. 119193-37-2. Molecular formula: C17H22N4O. Mole weight: 298.39. | |
| LY-278,584 POTENT 5-HT3 ANTAGONI | Heterocyclic Organic Compound. CAS No. 109216-58-2. Catalog: ACM109216582. | |
| LY2795050 | LY2795050 is a short-acting selective κ(kappa)-opioid receptor (KOR) antagonist. LY2795050 has high affinity for the KOR with K i value of 0.72 nM. LY2795050 can be used for the research of central nervous system dysfunction [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346133-08-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15708. | |
| LY2795050 | LY2795050, a κ-opioid Receptor antagonist, has been found to be effective in imaging KOR behaving as a PET tracer. IC50: 0.72 nM and 25.8 nM for κ-opioid Receptor and κ-opioid. Uses: Ly2795050 is a κ-opioid receptor antagonist that has been found to be effective in imaging kor behaving as a pet tracer. Synonyms: LY2795050; LY 2795050; LY-2795050; (S)-LY2795050; UNII-71PAL357HO; CHEMBL1921842; 71PAL357HO; BDBM50358166. Grades: 98%. CAS No. 1346133-08-1. Molecular formula: C23H22ClN3O2. Mole weight: 407.89. | |
| LY2801653 | LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. Synonyms: LY-2801653; LY 2801653. Grades: >98%. CAS No. 1206799-15-6. Molecular formula: C30H22F2N6O3. Mole weight: 552.542. | |
| LY2801653 dihydrochloride | LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (K(I)) of 2 nM, a pharmacodynamic residence time (K(off)) of 0.00132 min(-1) and t(1/2) of 525 min [1]. LY2801653 was found to have potent activity against several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, DDR1/2 and against the serine/threonine kinases MKNK1/2. LY2801653 demonstrated in vitro effects on MET pathway-dependent cell scattering and cell proliferation; in vivo anti-tumor effects in MET amplified (MKN45), MET autocrine (U-87MG, and KP4) and MET over-expressed (H441) xenograft models; and in vivo vessel normalization effects. Synonyms: LY-2801653 dihydrochloride; LY 2801653 dihydrochloride. Grades: >98%. CAS No. 1206801-37-7. Molecular formula: C30H24Cl2F2N6O3. Mole weight: 625.45. | |
| LY-280748 | LY-280748, a tetrazol derivative, could probably be significant in some studies for its biological activities. Synonyms: LY 280748; LY280748; LY-280748. [1,1'-Biphenyl]-2-ol,5-ethyl-4-[[6-methyl-6-(2H-tetrazol-5-yl)heptyl]oxy]-, sodium salt (1:1); 2-Phenyl-4-ethyl-5-(6-(2H-tetrazol-5-yl)-6-methylheptyloxy)phenol sodium salt; LY-280748; ACMC-20d2d5. Grades: 98%. CAS No. 153226-99-4. Molecular formula: C23H29N4NaO2. Mole weight: 416.50. | |
| LY2811376 | LY2811376, under the IUPAC name (4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, is the first orally available non-peptidi Beta secretase (BACE) inhibitor (IC50 = 239-249 nM) with the potent effect of treating Alzheimer's Disease. In vivo, LY2811376 inhibits BACE1 activity by concomitantly reducing C99 and sAPPb, the two primary APP cleavage products generated by BACE1. In vitro, LY2811376 demonstrates concentration-dependent inhibition of hBACE1 with an IC50 of 239 and 249 nM. Synonyms: 4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)-; (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine; LY 2811376; LY-2811376; (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine. Grades: ≥95%. CAS No. 1194044-20-6. Molecular formula: C15H14F2N4S. Mole weight: 320.36. | |
| LY-281217 | LY-281217 is an organic opioid agonist. It can produce analgesic effects in mice. Uses: Ly-281217 can produce analgesic effects. Synonyms: LY 281217; LY281217; LY-281217. N,N-Di(2-propenyl)-L-Tyr-2-methyl-Ala-2-methyl-Ala-L-Phe-OH;N-[N-[N-(N,N-Di-2-propenyl-L-tyrosyl)-2-methylalanyl]-2-methylalanyl]-L-phenylalanine;(2S)-2-[[2-[[2-[[(2S)-2-[bis(prop-2-enyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]-2-methylpropanoyl]amino]-2-methylpropanoyl]amino]-3-phenylpropanoic acid;LY281217;L-Phenylalanine, N-(N-(N-(N,N-di-2-propenyl-L-tyrosyl)-2-methylalanyl)-2-methylalanyl)-. Grades: >99 %. CAS No. 105027-75-6. Molecular formula: C32H42N4O6. Mole weight: 578.71. | |
| LY2828360 | LY2828360 is a selective cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). LY2828360 (3 mg/kg per day i.p. × 12 days) suppressed chemotherapy-induced neuropathic pain produced by paclitaxel without producing tolerance in wild-type mice. Synonyms: LY-2828360; LY 2828360; 8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine. Grades: ≥98%. CAS No. 1231220-79-3. Molecular formula: C22H27ClN6O. Mole weight: 426.94. | |
| LY285434 | An antagonist of angiotensin II receptor. Synonyms: LY285434; LY 285434; LY-285434; 2-[5-[2-(2H-tetrazol-5-yl)phenyl]indol-1-yl]octanoic acid. CAS No. 159748-08-0. Molecular formula: C23H25N5O2. Mole weight: 403.48. | |
| LY2857785 | LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines. Synonyms: LY2857785; LY-2857785; LY 2857785. Grades: >98%. CAS No. 1619903-54-6. Molecular formula: C26H36N6O. Mole weight: 448.6. | |
| LY2874455 | LY2874455 exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship. Synonyms: LY2874455; LY 2874455; LY-2874455. Grades: >98%. CAS No. 1254473-64-7. Molecular formula: C21H19Cl2N5O2. Mole weight: 444.316. | |
| LY2874455 | LY2874455 is a pan-FGFR inhibitor with IC 50 s of 2.8, 2.6, 6.4, 6 nM for FGFR1 , FGFR2 , FGFR3 , FGFR4 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1254473-64-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13304. | |
| LY2880070 | LY2880070 is an orally active CHK1 inhibitor, IC 50 ? 1 nM. LY2880070 can be used as an anticancer agent for combination with DNA damaging agents [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1375637-35-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148962. | |
| LY 288513 | LY 288513 is a CCK2 receptor antagonist with IC50 value of 16nM. It shows anxiolytic and antipsychotic properties in vivo. Synonyms: LY 288513; LY288513; LY-288513; (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 147523-65-7. Molecular formula: C22H18BrN3O2. Mole weight: 436.3. | |
| LY2886721 | LY2886721, under the IUPAC name N-(3-(2-amino-4a,5,7,7a-tetrahydro-4H-furo(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide, is the first oral small molecule inhibitting Beta secretase (BACE) to reach Phase 2 clinical research. It was developed by Eli Lilly & Co. with the potention to treat Alzheimer's Disease. Synonyms: N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide; LY2886721; LY-2886721; LY 2886721. CAS No. 1262036-50-9. Molecular formula: C18H16F2N4O2S. Mole weight: 390.41. | |
| LY 2886721 hydrochloride | LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease. Uses: Potential treatment of alzheimer's disease. Synonyms: LY 2886721 hydrochloride; LY2886721 hydrochloride; LY-2886721 hydrochloride; N-[3-[(4aS,7aS)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide hydrochloride. Grades: 99%. CAS No. 1262036-49-6. Molecular formula: C18H16F2N4O2S.HCl. Mole weight: 426.87. | |
| LY 290324 | LY 290324, a quinoline derivative, has been found to be a Leukotriene D4 receptor antagonist that could be probably effective as antiallergic and antiasthmatic agent. It has no development-reported since 1998. Synonyms: LY290324; LY-290324; 5-(2-(1-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)benzyl)indol-7-yl)ethyl)-1H-tetrazole. Grades: 98%. CAS No. 146554-87-2. Molecular formula: C29H24Cl2N6. Mole weight: 527.45. | |
| LY2922470 | LY2922470 Inhibitor. Uses: Scientific use. Product Category: T15810. CAS No. 1423018-12-5. |  |
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