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| Product | Description | |
|---|---|---|
| Nutritional Coatings | Nutritional Coatings. Product ID: PE-0192. Category: Coating Systems Excipients. Product Keywords: Pharmaceutical Excipients; Coating Systems Excipients; Nutritional Coatings; PE-0192. Standard: ChP, USP, BP, EP, JP. Grade: Food grade, Pharmaceutical grade. |  |
| Nuvenzepine | Nuvenzepine, a new pirenzepine-analog, is an mAChR antagonist, administered intraduodenally, displayed a long-lasting and dose-dependent inhibition of neostigmine-induced intestinal motility in anaesthetized cats. Synonyms: 11-(1-methylpiperidine-4-carbonyl)-6H-pyrido[3,2-c][1,5]benzodiazepin-5-one; 11-(N-methylisonipecotyl)-6,11-dihydro-5H-pyrido(2,3-b)(1,5)benzodiazepin-5-one; DF 545; DF-545; nuvenzepine. CAS No. 96487-37-5. Molecular formula: C19H20N4O2. Mole weight: 336.39. |  |
| Nuzhenide | Cas No. 39011-92-2. | |
| Nuzhenide Impurity 1 | An impurity of Nuezhenide. Synonyms: methyl (5E,6S)-5-ethylidene-4-[2-[[(2R,3S,4S,5R,6R)-5-[2-[(2S,3E)-3-ethylidene-5-methoxycarbonyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-4-yl]acetyl]oxy-3,4-dihydroxy-6-[2-(4-hydroxyphenyl)ethoxy]oxan-2-yl]methoxy]-2-oxoethyl]-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylate. Grades: > 95%. Molecular formula: C48H64O27. Mole weight: 1073.03. | |
| NV-128 | NV-128 is a novel isoflavone derivative, which has been shown in pre-clinical studies to promote cancer cell death in multi drug resistant cancer cells by inducing caspase-independent DNA degradation and cancer cell death via the AKT-mTOR pathway. In contrast to phenoxodiol and triphendiol, NV-128 has been shown to induce caspase-independent DNA degradation and cancer cell death. It appears that in conjunction with autophagy induction, NV-128 induces caspase independent cell death via the AKT-mTOR pathway resulting in beclin sequestration of Bcl-2, Bax up-regulation and mitochondrial depolarization. As a consequence, endonuclease G translocates to the nucleus where it initiates DNA degradation and cell death. This offers an opportunity for use as a monotherapy in chemoresistant cancers and enhanced efficacy against cancer targets less susceptible to phenoxodiol. The option for co-administration of combinations of these drugs is also under investigation to extend the potential therapeutic range of this unique class of oncology compounds. Synonyms: NV-128; NV 128; NV128. CAS No. 1210335-22-0. | |
| NV-5138 | NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 possesses rapid antidepressant effects. Synonyms: 4-(difluoromethyl)-L-leucine; ((S)-2-Amino-5,5-difluoro-4,4-dimethylpentanoic acid. Grades: ≥98%. CAS No. 2095886-80-7. Molecular formula: C7H13F2NO2. Mole weight: 181.18. | |
| N-Valeryl-D-glucosamine | N-Valeryl-D-glucosamine, an imperative compound widely employed in the biomedical sector, is esteemed for its tremendous prospects in the pharmaceutical arena. Its significance lies in the development of therapeutic agents targeting diverse ailments encompassing inflammation and autoimmune disorders. Synonyms: N-Valeryl-D-glucosamine; 63223-57-4; N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]pentanamide; SCHEMBL5157878; N-N-VALERYL-D-GLUCOSAMILE; MFCD00059805; 2-Deoxy-2-valeramido-D-glucopyranose; 2-Deoxy-2-pentanamido-D-glucopyranose; V0011; T72746; W-203351; N-((3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)pentanamide. CAS No. 63223-57-4. Molecular formula: C11H21NO6. Mole weight: 263.29. | |
| N-valeryl-D,L-penicillamine | N-valeryl-D,L-penicillamine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| N-Valinyl-1-deoxy-D-glucitol | N-Valinyl-1-deoxy-D-glucitol is an exceptional biomedical compound, demonstrating remarkable potential in the research for diabetes. It serves as a potent α-glucosidase inhibitor. Synonyms: N-Glucosyl-L-valine. Molecular formula: C11H23NO7. Mole weight: 281.30. | |
| N-Vanillyldecanamide | N-Vanillyldecanamide is found in the fruits of Capsicum annuum L. var. annuum. Synonyms: Decylic acid vanillylamide. Grades: > 95%. CAS No. 31078-36-1. Molecular formula: C18H29NO3. Mole weight: 307.43. | |
| N-Vanillylnonanamide | 1g Pack Size. Group: Biochemicals, Organics, Research Organics & Inorganics. Formula: C17H27NO3. CAS No. 2444-46-4. Prepack ID 28253688-1g. Molecular Weight 293.4. See USA prepack pricing. |  |
| N-Vinyl-2-pyrrolidone | N-Vinyl-2-pyrrolidone. Group: Biochemicals. Alternative Names: 1-Vinyl-2-pyrrolidinone; 1-Vinylpyrrolidin-2-one. Grades: Highly Purified. CAS No. 88-12-0. Pack Sizes: 1kg, 2kg, 5kg. US Biological Life Sciences. | Worldwide |
| N-Vinyl-2-pyrrolidone 99+% (GC) | N-Vinyl-2-pyrrolidone 99+% (GC). Group: Biochemicals. Grades: GC. CAS No. 88-12-0. Pack Sizes: 100g, 250g, 1Kg, 4Kg, 5Kg. US Biological Life Sciences. | Worldwide |
| N-Vinylacetamide | N-Vinylacetamide. Group: Monomers. CAS No. 5202-78-8. Product ID: N-ethenylacetamide. Molecular formula: 85.1g/mol. Mole weight: C4H7NO. CC(=O)NC=C. InChI=1S/C4H7NO/c1-3-5-4(2)6/h3H, 1H2, 2H3, (H, 5, 6). RQAKESSLMFZVMC-UHFFFAOYSA-N. |  |
| N-Vinyl acetamide(nva) | N-Vinyl acetamide(nva). Group: Monomers. CAS No. 5202-78-8. Product ID: N-ethenylacetamide. Molecular formula: 85.1g/mol. Mole weight: C4H7NO. CC(=O)NC=C. InChI=1S/C4H7NO/c1-3-5-4(2)6/h3H, 1H2, 2H3, (H, 5, 6). RQAKESSLMFZVMC-UHFFFAOYSA-N. | |
| N-Vinyl-ε-caprolactam | Liquid; OtherSolid. Group: Monomers. CAS No. 2235-00-9. Product ID: 1-ethenylazepan-2-one. Molecular formula: 139.19g/mol. Mole weight: C8H13NO. C=CN1CCCCCC1=O. InChI=1S/C8H13NO/c1-2-9-7-5-3-4-6-8 (9)10/h2H, 1, 3-7H2. JWYVGKFDLWWQJX-UHFFFAOYSA-N. | |
| N-Vinyl-epsilon-caprolactam | 100g Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C8H13NO. CAS No. 2235-00-9. Prepack ID 90026843-100g. Molecular Weight 139.19. See USA prepack pricing. | |
| N-Vinyl-ε-caprolactam (stabilized with HO-TEMPO) | Liquid; OtherSolid. Group: Monomers. CAS No. 2235-00-9. Product ID: 1-ethenylazepan-2-one. Molecular formula: 139.19g/mol. Mole weight: C8H13NO. C=CN1CCCCCC1=O. InChI=1S/C8H13NO/c1-2-9-7-5-3-4-6-8 (9)10/h2H, 1, 3-7H2. JWYVGKFDLWWQJX-UHFFFAOYSA-N. | |
| n-Vinylformamide | N-Vinylformamide (NVF) is a class of N-vinylamide that is a precursor to amide and amine functional polymer. It has attractive properties that include high reactivity in polymerization and hydrolysis. Uses: Nvf can be used in the free radical polymerization formation of poly(nvf) with a molecular weight ranging from 104 to 106. Group: Polymer/macromoleculevinyl monomers. Alternative Names: n-ethenyl-formamid. CAS No. 13162-05-5. Molecular formula: C3H5NO. Mole weight: 71.08 g/mol. Purity: 0.98. Canonical SMILES: [H]C(=O)NC=C. Density: 1.014 g/mL at 25 °C (lit.). Catalog: ACM-MO-13162055. |  |
| N-Vinylphthalimide | This product is suitable for scientific research. Group: Organic & printed electronicsvinyl monomers. Alternative Names: 2-Vinylisoindoline-1,3-dione. CAS No. 3485-84-5. Molecular formula: C10H7NO2. Mole weight: 173.17 g/mol. Appearance: White to Light Yellow to Light Orange Powder to Crystal. Purity: 98.0%(GC). IUPACName: 2-ethenylisoindole-1,3-dione. Canonical SMILES: C=CN1C(=O)c2ccccc2C1=O. ECNumber: 222-473-4. Catalog: ACM-MO-3485845. | |
| N-Vinylphthalimide | N-Vinylphthalimide. Uses: This product is suitable for scientific research. Group: other materials monomers. Alternative Names: 2-Vinylisoindoline-1,3-dione. CAS No. 3485-84-5. Product ID: 2-ethenylisoindole-1,3-dione. Molecular formula: 173.17. Mole weight: C10H7NO2. C=CN1C(=O)c2ccccc2C1=O. 1S/C10H7NO2/c1-2-11-9 (12)7-5-3-4-6-8 (7)10 (11)13/h2-6H, 1H2. IGDLZDCWMRPMGL-UHFFFAOYSA-N. >98.0%(GC)(N). | |
| N-Vinylphthalimide | 1g Pack Size. Group: Building Blocks, Organics. Formula: C10H7NO2. CAS No. 3485-84-5. Prepack ID 89997051-1g. Molecular Weight 173.17. See USA prepack pricing. | |
| N-Vinylpyrrolidone | Polyvinylpyrrolidone is a white powder. Compatible with a wide range of hydrophilic and hydrophobic resins. (NTP, 1992);Liquid;White or nearly white powder;YELLOW-TO-BROWN HYGROSCOPIC POWDER.;COLOURLESS-TO-YELLOW LIQUID.;White powder. Group: Polymers. Product ID: 1-ethenylpyrrolidin-2-one. Molecular formula: 111.14g/mol. Mole weight: (C6H9NO)n;C6H9NO;C6H9NO. C=CN1CCCC1=O. InChI=1S/C6H9NO/c1-2-7-5-3-4-6 (7)8/h2H, 1, 3-5H2. WHNWPMSKXPGLAX-UHFFFAOYSA-N. | |
| n-vinylpyrrolidone/styrene copolymer | n-vinylpyrrolidone/styrene copolymer. Group: Polymers. CAS No. 25086-29-7. Pack Sizes: 1 g. Mole weight: C14H17NO. | |
| N-Vinylpyrrolidone Technical 95%min | N-Vinylpyrrolidone Technical 95%min. Group: Polymers. | |
| NVP 2 | NVP 2 is a potent, ATP-competitive CDK9 inhibitor with IC50 value of 0.5 nM, exhibiting selectivity for CDK9 over a panel of 468 kinases. Synonyms: 4- [ [ [5'-Chloro-2'- [ [trans-4- [ [ (1R) -2-methoxy-1-methylethyl]amino]cyclohexyl]amino] [2, 4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile. Grades: ≥97% by HPLC. CAS No. 1263373-43-8. Molecular formula: C27H37ClN6O2. Mole weight: 513.07. | |
| NVP 231 | NVP 231. Group: Biochemicals. Grades: Purified. CAS No. 362003-83-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| NVP-231 | NVP-231. Group: Biochemicals. Alternative Names: N-[2-(Benzoylamino)-6-benzothiazolyl]-tricyclo[3.3.1.13, 7]decane-1-carboxamide; NVP 231. Grades: Highly Purified. CAS No. 362003-83-6. Pack Sizes: 10mg. Molecular Formula: C25H25N3O2S, Molecular Weight: 431.55. US Biological Life Sciences. | Worldwide |
| NVP-231 | NVP-231 is a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK. NVP-231 is active in the low nanomolar range on purified as well as cellular CerK and abrogates phosphorylation of ceramide, resulting in decreased endogenous C1P levels. When combined with another ceramide metabolizing inhibitor, such as tamoxifen, NVP-231 synergistically increased ceramide levels and reduced cell growth. Therefore, NVP-231 represents a novel and promising compound for controlling ceramide metabolism that may provide insight into CerK physiological function. Synonyms: NVP-231; NVP 231; NVP231. CAS No. 362003-83-6. Molecular formula: C25H25N3O2S. Mole weight: 431.554. | |
| NVP-AAM077 Tetrasodium Hydrate (NVP-AAM077, [[[ (1S) -1- (4-Bromophenyl) ethyl]amino] (1, 2, 3, 4-tetrahydro-2, 3-dioxo-5-quinoxalinyl) methyl] Phosphonic Acid Tetrasodium Hydrate, PEAQX Tetrasodium Hydrate, NMDA Antagonist VII) | A potent antagonist for NMDA receptors. Modestly higher selectivity for the NR2A than for the NR2B containing NMDA receptors (IC50 = 0.015 and 0.078uM) but insufficient to discriminate between NR2A and NR2B-containing NMDA receptors. Widely used for researches in synaptic plastic, learning and memory, and epilepsy. Group: Biochemicals. Grades: Highly Purified. CAS No. 459836-30-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| NVP-ABE-171 | NVP-ABE171 is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) values of 602, 34, 1230, and 1.5 nM. Uses: Pde4 inhibitor. Synonyms: ABE171; ABE-171; ABE 171; NVP-ABE171; NVP-ABE-171; NVP-ABE 171. 4-[8-(2,1,3-benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acid; 4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyridin-6-yl)benzoic acid. Grades: ≥95%. CAS No. 426268-06-6. Molecular formula: C21H12N4O3. Mole weight: 368.35. | |
| NVP-ACC789 | NVP-ACC789 is a potent, selective and orally active inhibitor of the VEGF receptor tyrosine kinases, antagonizing tumor-driven angiogenesis. Uses: A potent, selective and orally active inhibitor of the vegf receptor tyrosine kinases. Synonyms: NVP-ACC789; NVP-ACC 789; NVP-ACC-789; ACC-789; ACC 789; ACC789; ZK-202650; ZK 202650; ZK202650.AC1OCFN3;N-(3-bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine. Grades: ≥96%. CAS No. 300842-64-2. Molecular formula: C21H17BrN4. Mole weight: 405.3. | |
| NVP ADW 742 | NVP ADW 742. Group: Biochemicals. Grades: Purified. CAS No. 475488-23-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| NVP-AEW541 | NVP-AEW541 is a selective inhibitor of Insulin-like growth factor 1 receptor (IGF-1R) kinase. It abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. In vivo, NVP-AEW541 inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. Synonyms: AEW-541; AEW 541; AEW541; 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine. Grades: ≥98%. CAS No. 475488-34-7. Molecular formula: C27H29N5O. Mole weight: 439.6. | |
| NVP-AUY 922 | NVP-AUY 922 is a potent inhibitor of heat shock protein 90 (Hsp90) that prevents the proliferation of a range of human cancer cell lines. NVP-AUY 922 has been shown to enhance the radiation sensitivity of tumor cell lines under hypoxia. Group: Biochemicals. Alternative Names: 5-[2, 4-Dihydroxy-5- (1-methylethyl) phenyl]-N-ethyl-4-[4- (4-morpholinylmethyl) phenyl]-3-isoxazolecarboxamide; VER 52296; NVP-AUY922. Grades: Highly Purified. CAS No. 747412-49-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| NVP-BAG956 | NVP-BAG956. Group: Biochemicals. Alternative Names: 2-Methyl-2- [4- [2-methyl-8- [ (pyridin-3-yl) ethynyl] imidazo [4, 5-c] quinolin-1-yl] phenyl] propionitrile; BAG 956; NVP-BAG 956; α , α -Dimethyl-4- [2-methyl-8- (3-pyridinylethynyl) -1H-imidazo [4, 5-c] quinolin-1-yl] benzeneacetonitrile. Grades: Highly Purified. CAS No. 853910-02-8. Pack Sizes: 10mg. Molecular Formula: C28H21N5, Molecular Weight: 427.5. US Biological Life Sciences. | Worldwide |
| NVP-BAG956 | NVP-BAG956 is a potent, ATP-competitive and selective dual PI3K and PDK1 inhibitor in vitro and in vivo. It inhibits cellular AKT phosphorylation at Thr308 and blocks cell proliferation, causing arrest in G1 phase of the cell cycle. It slows tumor progression in mouse xenograft models. Synonyms: BAG-956; BAG 956; BAG956; NVP-BAG956; NVP-BAG-956; NVP-BAG 956. Grades: >98%. CAS No. 853910-02-8. Molecular formula: C28H21N5. Mole weight: 427.5. | |
| NVP-BBD130 | NVP-BBD130 is a potent and selective dual PI3K/mTOR inhibitor. It can suppress the growth and proliferation of melanoma primary tumors and metastasis via inhibiting NVP-BEZ235 and BBD130. Uses: Antitumor agent. Synonyms: 2-methyl-2-[4-[3-methyl-2-oxo-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile. Grades: 99%. CAS No. 853910-61-9. Molecular formula: C28H21N5O. Mole weight: 443.5. | |
| NVP-BEP800 | NVP-BEP800 is a novel, fully synthetic Hsp90β inhibitor with IC50 of 58 nM, which exhibits >70-fold selectivity against Hsp90 family members Grp94 and Trap-1. Synonyms: VER82576; VER 82576; VER-82576; XL184; XL 184; XL-184; BMS-907351; BMS 907351; BMS907351; NVP BEP800; NVP-BEP 800; NVP BEP-800; BEP-800; BEP800; BEP 800. Grades: >98%. CAS No. 847559-80-2. Molecular formula: C21H23Cl2N5O2S. Mole weight: 480.41. | |
| NVP-BEZ 235 | Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR. Group: Biochemicals. Alternative Names: 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-benzeneacetonitrile; 2-Methyl-2- [4- [3-methyl-2-oxo-8- (quinolin-3-yl) -2, 3-dihydroimidazo [4, 5-c] quinolin-1-yl] phenyl] propionitrile; BEZ 235. Grades: Highly Purified. CAS No. 915019-65-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| NVP-BEZ 235-d3 | 2H Labeled Compounds. CAS No. 1133206-74-2. Molecular formula: C30H20D3N5O. Mole weight: 472.56. Catalog: ACM1133206742. | |
| NVP-BGJ398 phosphate | Potent and selective inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively); it showed siginificant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3. Synonyms: Infigratinib phosphate; BGJ-398 phosphate; NVP-BGJ398 phosphate; NVPBGJ398 phosphate. Grades: >98%. CAS No. 1310746-10-1. Molecular formula: C26H34Cl2N7O7P. Mole weight: 658.47. | |
| NVP BHG 712 | NVP BHG 712. Group: Biochemicals. Grades: Purified. CAS No. 940310-85-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| NVP-BHG712 | NVP-BHG712 is a EphB4 kinase inhibitor and BCR-ABL inhibitor. NVP-BHG712, which inhibits EphB4 kinase activity in the low nanomolar range in cellular assays showed high selectivity for targeting the EphB4 kinase when profiled against other kinases in biochemical as well as in cell based assays. Furthermore, NVP-BHG712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral administration. In vivo, NVP-BHG712 inhibits VEGF driven vessel formation, while it has only little effects on VEGF receptor (VEGFR) activity in vitro or in cellular assays. The data shown here suggest a close cross talk between the VEGFR and EphR signaling during vessel formation. In addition to its established function in vascular remodeling and endothelial arterio-venous differentiation, EphB4 forward signaling appears to be an important mediator of VEGF induced angiogenesis since inhibition of EphB4 forward signaling is sufficient to inhibit VEGF induced angiogenesis. Synonyms: NVP BHG712; NVP BHG-712; NVP BHG 712; BHG-712; BHG712; BHG 712. CAS No. 940310-85-0. Molecular formula: C26H20F3N7O. Mole weight: 503.489. | |
| NVP-BHG712 | NVP-BHG712 / BHG-712 inhibits EphB4 kinase activity in the low nanomolar range in cellular assays showed high selectivity for targeting the EphB4 kinase when profiled against other kinases in biochemical as well as in cell based assays. It also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively. Group: Fluorinated apis. Alternative Names: BHG-712. CAS No. 940310-85-0. Molecular formula: C26H20F3N7O. Mole weight: 503.48. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 4-methyl-3-[ (1-methyl-6-pyridin-3-ylpyrazolo[3, 4-d]pyrimidin-4-yl)amino]-N-[3- (trifluoromethyl)phenyl]benzamide. Catalog: OFC940310850. | |
| NVP-BKM 120 | NVP-BKM 120. Group: Biochemicals. Alternative Names: BKM 120; Buparlisib; 5-(2,6-di-4-Morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine. Grades: Highly Purified. CAS No. 944396-07-0. Pack Sizes: 5mg. Molecular Formula: C18H21F3N6O2, Molecular Weight: 410.39. US Biological Life Sciences. | Worldwide |
| NVP-BKM120 Hydrochloride | NVP-BKM120 Hcl(BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Synonyms: BKM-120 hydrochloride; BKM120 hydrochloride; BKM 120 hydrochloride. Grades: >98%. CAS No. 1312445-63-8. Molecular formula: C18H22ClF3N6O2. Mole weight: 446.85. | |
| NVP-BSK805 | NVP-BSK805, a quinoxaline derivative, is a selective ATP-competitive JAK2 inhibitor which could induce apoptosis (GI50 < 100 nM) and restrain the growth of JAK2V617F cells (Ba/F3). Synonyms: 4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine; BSK 805; 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)quinoxaline. Grades: 98%. CAS No. 1092499-93-8. Molecular formula: C27H28F2N6O. Mole weight: 490.55. | |
| NVP-BVU972 | NVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM. Synonyms: NVP BVU972; NVPBVU972; NVP-BVU972; BVU-972; BVU 972; BVU972. Grades: >98%. CAS No. 1185763-69-2. Molecular formula: C20H16N6. Mole weight: 340.38. | |
| NVP-CGM097 sulfate | NVP-CGM097 sulfate, a dihydroisoquinolinone derivative, is a potent and selective MDM2 inhibitor (IC50 = 1.7±0.1 nM for hMDM2) in the treatment of p53wt tumors. Synonyms: (1S)-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[[4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl]methyl]amino]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one;sulfuric acid; NVP-CGM097 (sulfate). CAS No. 1313367-56-4. Molecular formula: C38H49ClN4O8S. Mole weight: 757.34. | |
| NVP CXCR2 20 | NVP CXCR2 20 is a potent and selective CXCR2 antagonist. Synonyms: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile; NVP-CXCR2 20; NVP CXCR2-20; NVP CXCR220. CAS No. 1029521-30-9. Molecular formula: C15H11F2N3OS. Mole weight: 319.33. | |
| NVP DPP 728 dihydrochloride | NVP DPP 728, a cyanopyrrolidine, is a potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor with excellent oral bioavailability and potent antihyperglycemic activity (Ki = 11 nM, IC50=14 nM). NVP DPP 728 exhibits > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Synonyms: NVP DPP 728 dihydrochloride; NVPDPP728 dihydrochloride; NVP-DPP-728 dihydrochloride; 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile dihydrochloride. Grades: ≥97% by HPLC. CAS No. 207556-62-5. Molecular formula: C15H18N6O.2HCl. Mole weight: 371.27. | |
| NVP DPP 728 dihydrochloride | NVP DPP 728 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 207556-62-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| NVP-HDM201 | NVP-HDM201 (HDM201) is a potent and highly specific MDM-2/p53 inhibitor that binds to human Mdm2 protein with a sub-nanomolar Ki value, activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells. Synonyms: Siremadlin; HDM201; HDM 201; HDM-201; NVP-HDM-201; NVP-HDM 201. CAS No. 1448867-41-1. Molecular formula: C26H24Cl2N6O4. Mole weight: 555.41. | |
| NVP-LCQ195 | NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5. It induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-lmol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. It suppressed the expression of transcription factors including myc, IRF4 and XBP-1. Synonyms: NVP-LCQ-195; NVP-LCQ 195; NVP-LCQ195. LCQ-195; LCQ 195; LCQ195; AT9311; AT-9311; AT 9311. Grades: >98%. CAS No. 902156-99-4. Molecular formula: C17H19Cl2N5O4S. Mole weight: 460.33. | |
| NVP-QAV-572 | NVP-QAV-572 is a potent PI3K kianse inhibitor. Grades: >98%. CAS No. 957209-68-6. Molecular formula: C17H19F2N7O3S2. Mole weight: 471.5. | |
| NVP-QAV680 | NVP-QAV680 is a potent and selective CRTh2 receptor antagonist with Ki of 36 nM by 3H-PGD2 filtration binding assay. Synonyms: QAV-690 free acid; QAV690 free acid; QAV 690 free acid; NVP-QAV680; NVP ; NVPQAV680; NVP-QAV-680. Grades: >98%. CAS No. 872365-16-7. Molecular formula: C18H18N2O4S. Mole weight: 358.41. | |
| NVR 3-778 | NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50% effective concentration (EC50) of 0.40?μM in HepG2.2.15 cells. The antiviral profile of NVR 3-778 indicates pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication. Group: Inhibitors. Alternative Names: NVR 3 778; NVR3 778; NVR-3-778; K-89; K 89; K89; NVR3778; NVR 3778; NVR-3778. CAS No. 1445790-55-5. Molecular formula: C18H16F4N2O4S. Mole weight: 432.39. Appearance: Solid powder. Purity: >98%. IUPACName: 4-Fluoro-3-((4-hydroxypiperidin-1-yl)sulfonyl)-N-(3,4,5-trifluorophenyl)benzamide. Canonical SMILES: O=C (NC1=CC (F)=C (F)C (F)=C1)C2=CC=C (F)C (S (=O) (N3CCC (O)CC3)=O)=C2. Catalog: ACM1445790555. | |
| NVS-CECR2-1 | NVS-CECR2-1 is a potent and selective CECR2 (cat eye syndrome chromosome region, candidate 2) inhibitor (IC50 = 47 nM). NVS-CECR2-1 showed no cross reactivity in a BRD panel of 48 targets or any major activity in kinase, protease and receptor panels. CECR2 (cat eye syndrome chromosome region, candidate 2) is a component of chromatin complexes that regulate gene expression controlling development. Synonyms: NVS-CECR2-1; NVS CECR2 1; NVSCECR21; NVS-1; NVS 1; NVS1; N-Cyclopropyl-2-(propylsulfonyl)-6-(1-(2,2,6,6-tetramethylpiperidin-4-yl)-1H-indol-5-yl)pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 1992047-61-6. Molecular formula: C27H37N5O2S. Mole weight: 495.68. | |
| NVS-CRF38 | NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility. Synonyms: NVS-CRF 38; NVS-CRF-38. Grades: >98%. CAS No. 1207258-55-6. Molecular formula: C19H21N5O2. Mole weight: 351.4. | |
| NVS-PAK1-1 | NVS-PAK1-1 is a specific allosteric PAK1 inhibitor. Group: Inhibitors. Alternative Names: NVS-PAK1-1; NVSPAK11; NVS PAK1 1. CAS No. 1783816-74-9. Molecular formula: C23H25ClF3N5O. Mole weight: 479.93. Appearance: Solid powder. Purity: >98%. IUPACName: 3(S)-[2-Chloro-5-(2,2-difluoro-ethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino]-pyrrolidine-1-carboxylic acid isopropylamide. Canonical SMILES: O=C (N1C[C@@H] (NC2=NC3=CC (F)=CC=C3N (CC (F)F)C4=CC=C (Cl)C=C42)CC1)NC (C)C. Catalog: ACM1783816749. | |
| NVS-PAK1-1 | NVS-PAK1-1 is potent and specific allosteric PAK1 inhibitor (IC50 = 5 nM) with selective over PAK2 and a panel of 442 kinases. Synonyms: NVS-PAK1-1; NVSPAK11; NVS PAK1 1; (3S)-3-[[8-chloro-11-(2,2-difluoroethyl)-3-fluorobenzo[b][1,4]benzodiazepin-6-yl]amino]-N-propan-2-ylpyrrolidine-1-carboxamide. CAS No. 1783816-74-9. Molecular formula: C23H25ClF3N5O. Mole weight: 479.93. | |
| NVS PAK1 C | NVS PAK1 C is the negative control of NVS PAK1 1. NVS PAK1 1 is a potent and selective PAK1 inhibitor (IC50 = 5 nM). Selective for PAK1 over PAK2 and a panel of 442 kinases. Synonyms: (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide. Grades: ≥98% by HPLC. CAS No. 2250019-95-3. Molecular formula: C22H23ClF3N5O. Mole weight: 465.91. | |
| NVS-ZP7-4 | NVS-ZP7-4 inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. Group: Fluorinated apis. Alternative Names: 1'-[(2S)-2-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-3-phenylpropyl]spiro[1,3-dihydroquinazoline-4,4'-piperidine]-2-one. CAS No. 2349367-89-9. Molecular formula: C28H28FN5OS. Mole weight: 501.62. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 1'-[(2S)-2-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-3-phenylpropyl]spiro[1,3-dihydroquinazoline-4,4'-piperidine]-2-one. Catalog: OFC2349367899. | |
| Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran) -5-sulfonyl-D-arginine | Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran) -5-sulfonyl-D-arginine. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine 99+% (HPLC) | Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine allyl ester hydrochloride ≥95% (HPLC) | Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine allyl ester hydrochloride ≥95% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 257288-23-6. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine methyl ester hydrochloride 99+% (TLC) | Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine methyl ester hydrochloride 99+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-D-arginine | Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-D-arginine. Group: Biochemicals. Alternative Names: D-Arg(Pmc)-OH. Grades: Highly Purified. CAS No. 191869-60-0. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-D-arginine-2-chlorotrityl resin | Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-D-arginine-2-chlorotrityl resin. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g. US Biological Life Sciences. | Worldwide |
