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| Product | Description | |
|---|---|---|
| Q-VD-OPH | QVD-OPH, also known as Quinoline-Val-Asp-Difluorophenoxymethylketone, is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 (IC50 = 25nm), caspase-1 (IC50 = 50nM), caspase-8 (IC50 = 100nM) and caspase-9 (IC50 = 430nM). It can be used in Alzheimer's studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor. Synonyms: Q-VD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone; quinoline-val-asp(OMe)-CH2-OPH. Grades: >98%. CAS No. 1135695-98-5. Molecular formula: C26H25F2N3O6. Mole weight: 513.8. |  |
| Q-VD-OPh (Anhydrous) | Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6- difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies. CAS Number:1135695-98-5 (anhydrous). Group: Biochemicals. Alternative Names: Q-Val-Asp-OPh; pan-Caspase Inhibitor; N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone, (3S) -5- (2, 6-Difluorophenoxy) -3-[[ (2S) -3-methyl-1-oxo-2-[ (2-quinolinylcarbonyl) amino]butyl]amino]-4-oxo-pentanoic Acid. Grades: Highly Purified. CAS No. 1135695-98-5. Pack Sizes: 1mg, 3x1mg, 5mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. |  Worldwide |
| Q-VD-OPh hydrate | Heterocyclic Organic Compound. Alternative Names: Q-VD-OPh, Q-VD-OPh hydrate, Q-Val-Asp-OPH, 1135695-98-5, Quinoline-Val-Asp-Difluorophenoxymethylketone, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl ketone, S7311,1135695-98-5. CAS No. 1135695-98-5. Molecular formula: C26H25F2N3O6. Mole weight: 513.49 (anhydrous basis). Purity: 0.96. IUPACName: (3S)-5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-2-(quinoline-2-carbonylamino)butanoyl]amino]-4-oxopentanoic acid. Canonical SMILES: CC (C)C (C (=O)NC (CC (=O)O)C (=O)COC1=C (C=CC=C1F)F)NC (=O)C2=NC3=CC=CC=C3C=C2. Catalog: ACM1135695985. |  |
| Q-VE-OPh (Negative Control) | Cell permeable, non-toxic negative control for the caspase inhibitor Q-VD-OPh. Stable in aqueous environment. Several folds less inhibitory activity than Q-VD-OPh. Perfect for both in vitro and in vivo studies. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C27H27F2N3O6. US Biological Life Sciences. | Worldwide |
| QWF | QWF is a tripeptide substance P (SP) antagonist with IC50 value of 90 μM that inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Synonyms: Bgtcpo; N(alpha)-(N(alpha)-(N(alpha)-(tert-Butyloxycarbonyl)glutaminyl)-N(1)-formyl-tryptophyl)phenylalanine benzyl ester; Boc-gln-trp(cho)-phe-obzl. CAS No. 126088-82-2. Molecular formula: C38H43N5O8. Mole weight: 697.78. | |
| QX 222 | QX 222, a quaternary ammonium derivative of lidocaine, is a sodium channel blocker. Synonyms: QX 222; QX222; QX-222; 2-[(2,6-Dimethylphenyl)amino]-N,N,N-trimethyl-2-oxoethaniminium Chloride; Trimethyl[(2,6-xylylcarbamoyl)methyl]ammonium Chloride (8CI); 2-[(2,6-dimethylphenyl)amino]-N,N,N-trimethyl-2-oxo-ethanaminium Chloride (9CI); Trimethyl[(2,6-xylylcarbamoyl)methyl]ammonium Chloride (7CI); 2-Dimethylamino-2',6'-dimethylacetanilide Methochloride; QX 222 Chloride. CAS No. 5369-00-6. Molecular formula: C13H21ClN2O. Mole weight: 256.77. | |
| QX 222 | QX 222. Group: Biochemicals. Grades: Purified. CAS No. 5369-00-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| QX 314 bromide | QX 314 bromide. Group: Biochemicals. Grades: Highly Purified. CAS No. 24003-58-5. Pack Sizes: 100mg. Molecular Formula: C16H27N2OBr, Molecular Weight: 343.31. US Biological Life Sciences. | Worldwide |
| QX 314 bromide | QX 314, a membrane impermeable quaternary derivative of lidocaine, selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. Synonyms: QX-314 Br; QX-314Br; QX314 Br; QX 314; QX314. 2-[(2,6-Dimethylphenyl)amino]-N,N,N-triethyl-2-oxo-ethanaminium Bromide; Triethyl[(2,6-xylylcarbamoyl)methyl]-ammonium Bromide; 2-[(2,6-Dimethylphenyl)amino]-N,N,N-triethyl-2-oxo-ethanaminium Bromide; N- (2, 6-Dimethylphenylcarbamoylmethyl) triethylammonium Bromide. Grades: ≥99% by HPLC. CAS No. 24003-58-5. Molecular formula: C16H27N2OBr. Mole weight: 343.31. | |
| QX 314 chloride | QX 314 chloride. Group: Biochemicals. Grades: Purified. CAS No. 5369-3-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| QX 314 chloride | QX 314 chloride, a membrane-impermeant lidocaine derivative, is a blocker of voltage-activated Na+ channels. QX-314 elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. Synonyms: QX 314 chloride; QX314 chloride; QX-314 chloride; N- (2, 6-Dimethylphenylcarbamoylmethyl) triethylammonium chloride; N-Ethyllidocaine. Grades: ≥99% by HPLC. CAS No. 5369-3-9. Molecular formula: C16H27N2OCl. Mole weight: 298.85. | |
| QX77 | QX-77 is an activator of molecular chaperone-mediated autophagy (CMA). It can induce the up-regulation of Rab11 expression and up-regulate the expression of LAMP2A. Grades: 98%. CAS No. 1798331-92-6. Molecular formula: C16H13ClN2O2. Mole weight: 300.74. | |
