Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| (2S,4R)-Sacubitril | (2S,4R)-Sacubitril is the enantiomer and an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan. Group: Biochemicals. Grades: Highly Purified. CAS No. 761373-05-1. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C24H29NO5. US Biological Life Sciences. |  Worldwide |
| (2S,4R)-Sacubitril | (2S,4R)-Sacubitril. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: [1,1'-Biphenyl]-4-pentanoic acid, ?-[(3-carboxy-1-oxopropyl)amino]-?-methyl-, ?-ethyl ester, [R-(R*,S*)]- (9CI), (2S,4R)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester, (2S,4R)-Sacubitril, (2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,[1,1'-Biphenyl]-4-pentanoic acid, ?-[(3-carboxy-1-oxopropyl)amino]-?-methyl-, 4-ethyl ester, (?S,?R)-. CAS No. 761373-05-1. IUPAC Name: 4-[[(2R,4S)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid. Molecular formula: C24H29NO5. Mole weight: 411.49. Catalog: APS761373051. SMILES: CCOC(=O)[C@@H](C)C[C@H](Cc1ccc(cc1)c2ccccc2)NC(=O)CCC(=O)O. Format: Neat. |  |
| Sacubitril Enantiomer | Sacubitril enantiomer.Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. Synonyms: 2R,4S-Sacubitril; (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester; 4-[[(2R,4S)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid; (2S,4R)-Sacubitril; SCHEMBL22420467; CS-M3545; AKOS030528367; HY-78847; MS-27102; PD100765; L10003; EN300-6474615; A854860; [1,1'-Biphenyl]-4-pentanoic acid, |A-[(3-carboxy-1-oxopropyl)amino]-|A-methyl-, 4-ethyl ester, (|AS,|AR)-; 3-{[(2R,4S)-1-{[1,1'-biphenyl]-4-yl}-5-ethoxy-4-methyl-5-oxopentan-2-yl]carbamoyl}propanoic acid; 4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid; (alphaS,gammaR)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester. Grades: > 95%. CAS No. 761373-05-1. Molecular formula: C24H29NO5. Mole weight: 411.5. |  |
| AHU-377 hemicalcium salt | LCZ696 is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). Oral administration of LCZ696 caused dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provided sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats. In healthy participants, a randomized, double-blind, placebo-controlled study (n = 80) of single-dose (200-1200 mg) and multiple-dose (50-900 mg once daily for 14 days) oral administration of LCZ696 showed that peak plasma concentrations were reached rapidly for valsartan (1.6-4.9 hours), AHU377 (0.5-1.1 hours), and its active moiety, LBQ657 (1.8-3.5 hours). LCZ696 is superior to valsartan alone in reducing blood pressure. Preliminary results from a Phase II trial showed that LCZ696 reduced NT-proBNP to a greater extent than valsartan alone, and in addition LCZ696 had beneficial effects on symptoms. Synonyms: calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate; AHU337; AHU-337; AHU 337; LCZ696; LCZ 696; LCZ696; Sacubitril. Grades: >98%. CAS No. 1369773-39-6. Molecular formula: C24H28NO5-. Mole weight: 410.48. | |
| LCZ696 (valsartan + sacubitril) impurity 19 | LCZ696 (valsartan + sacubitril) impurity 19. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,4R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid. CAS No. 1012341-54-6. Molecular formula: C23H29NO4. Mole weight: 383.48. Catalog: APB1012341546. | |
| Sacubitril sodium | Sacubitril, also known as AHU377, is a first-in-class medicine that contains a neprilysin (NEP) inhibitor (sacubitril) and an angiotensin II (Ang-II) receptor blocker (valsartan). Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. Synonyms: sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate; Sacubitril sodium; AHU377; AHU 377; AHU-377; LCZ696. CAS No. 149690-05-1. Molecular formula: C24H29NO5.Na. Mole weight: 434.47. | |
Our database is helping our users find suppliers everyday.
