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| Product | Description | |
|---|---|---|
| (S)-(-)-5-Iodowillardiine | (S)-(-)-5-Iodowillardiine. Group: Biochemicals. Grades: Purified. CAS No. 140187-25-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| (S)-(-)-5-Iodowillardiine | (S)-(-)-5-Iodowillardiine is a potent agonist highly selective for GluK1-containing subtype kainate receptors with EC50 value of 0.21 μM. It does not interact with GluK2, GluK6, and GluK7 receptors, and has low affinity for AMPA receptors. It also has high affinity for the kainate receptor subtype hGluR5 and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluR6. It has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in apoptosis, necrosis and neuropathic pains. Synonyms: (S)-5-Iodowillardiine; (S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid; (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid; Iodowillardiine. Grades: ≥98% by HPLC. CAS No. 140187-25-3. Molecular formula: C7H8IN3O4. Mole weight: 325.06. |  |
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