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| Product | Description | |
|---|---|---|
| (Z)-4-Hydroxytamoxifen | tamoxifen metabolite, anti-estrogen, see Tamoxifen 1,01038. CAS No. 68047-06-3. Product ID: 1-01039. Molecular formula: C26H29NO2. Mole weight: 387.52. Reference: J. Med. Chem., 28, 1491, 1985; J. Biol. Chem, 269, 4458, 1994; Cancer Res., 52, 4969, 1992. |  |
| (Z)-4-Hydroxytamoxifen | (Z)-4-Hydroxytamoxifen is a metabolite of Tamoxifen and acts as an estrogen receptor antagonist. It exhibits more than 100-fold affinity over Tamoxifen. (Z)-4-Hydroxytamoxifen also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing. Synonyms: Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-; 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol; Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-; Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-, (Z)-; (Z)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-en-1-yl]phenol; 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; 4-Hydroxy-(Z)-tamoxifen; 4-Hydroxytamoxifen; Hydroxytamoxifen; ICI 79280; trans-4-Hydroxytamoxifen; trans-Hydroxytamoxifen. Grades: ≥98% by HPLC. CAS No. 68047-06-3. Molecular formula: C26H29NO2. Mole weight: 387.51. |  |
| (Z)-4-Hydroxytamoxifen | (Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen. (Z)-4-Hydroxy Tamoxifen is a hydroxylated analogue of Tamoxifen. (Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen with anti-estrogenic properties. Estrogen receptor modulator. Activates intein-linked inactive Cas9 to reduce off target effects of CRISPR-mediated gene editing. Group: Biochemicals. Alternative Names: 4-[ (1Z) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; 4-Hydroxy-(Z)-tamoxifen; 4-Hydroxytamoxifen; Hydroxytamoxifen; ICI 79280. Grades: Highly Purified. CAS No. 68047-06-3. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C26H29NO2, Molecular Weight: 387.51. US Biological Life Sciences. |  Worldwide |
| (E/Z)-4-Hydroxytamoxifen | (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor ( GPER ) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Afimoxifene; 4-OHT. CAS No. 68392-35-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16950A. |  |
| N-Demethyl-3-methoxy-4-hydroxytamoxifen-d3 Hydrochloride. (Z,E mixture) | N-Demethyl-3-methoxy-4-hydroxytamoxifen-d3 Hydrochloride (Z,E mixture). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C26H27D3ClNO3, Molecular Weight: 442.99. US Biological Life Sciences. | Worldwide |
| N-Demethyl-3-methoxy-4-hydroxytamoxifen Hydrochloride. (Z,E mixture) | N-Demethyl-3-methoxy-4-hydroxytamoxifen Hydrochloride (Z,E mixture). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C26H30ClNO3, Molecular Weight: 439.97. US Biological Life Sciences. | Worldwide |
| 4-Hydroxytamoxifen | 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator ( SERM ). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation. 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is also the active metabolic form of Tamoxifen (HY-13757A) in vivo and can be used to induce gene knockout in transgenic mice expressing CreER [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z)-Afimoxifene. CAS No. 68047-06-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16950. | |
| (E)-4-Hydroxytamoxifen | (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (E)-Afimoxifene. CAS No. 174592-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-16950B. | |
| (Z)-4-Hydroxy Tamoxifen-d5 | A labeled metabolite of Tamoxifen. A hydroxylated analogue of Tamoxifen with anti-estrogenic properties. Group: Biochemicals. Alternative Names: 4-[ (1Z) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen. Grades: Highly Purified. CAS No. 164365-20-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
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