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| Product | Description | |
|---|---|---|
| 1,5-Isoquinolinediol | 1,5-Isoquinolinediol is a PARP1 inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent leading to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. 1,5-Isoquinolinediol is also an inducible nitric oxide synthase (NOS2) inhibitor. 1,5-Isoquinolinediol significantly inhibited mitochondrial membrane potential loss, AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: 1,5-Dihydroxyisoquinoline; Isoquinoline-1,5-diol; 5-Hydroxy-1(2H)-isoquinolinone; 5-Hydroxyisocarbostyril. Grades: 99%. CAS No. 5154-2-9. Molecular formula: C9H7NO2. Mole weight: 161.16. |  |
| 1,5-Isoquinolinediol | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| 1,5-Isoquinolinediol | PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor. Stimulates homologous recombination. Group: Biochemicals. Alternative Names: 5-Hydroxy-1(2H)-isoquinolinone, 1,5-Dihydroxyisoquinoline. Grades: Highly Purified. CAS No. 5154-2-9. Pack Sizes: 5mg, 25mg, 100mg. Molecular Formula: C9H7NO2. US Biological Life Sciences. |  Worldwide |
| 1,5-Isoquinolinediol | Reagent used in the preparation of PARP inhibitor. Group: Biochemicals. Alternative Names: 5-Hydroxy-isoquinolinone; 1,5-Dihydroxyisoquinoline; NSC 65585. Grades: Highly Purified. CAS No. 5154-2-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
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