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| Product | Description | |
|---|---|---|
| 10-Hydroxycamptothecin | 10-Hydroxycamptothecin. Group: Biochemicals. Grades: Highly Purified. CAS No. 64439-81-2. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C20H16N2O5. US Biological Life Sciences. |  Worldwide |
| 10-Hydroxycamptothecin | 10mg Pack Size. Group: Analytical Reagents, Biochemicals. Formula: C20H16N2O5. CAS No. 64439-81-2. Prepack ID 23489857-10mg. Molecular Weight 115.1768. See USA prepack pricing. |  |
| 10-Hydroxycamptothecin | Cas No. 19685-09-7. |  |
| 10-Hydroxycamptothecine | therapeutic effects for liver cancer, stomach, and neck cancer and leukemia. CAS No. 64439-81-2. Product ID: 1-00923. Molecular formula: C20H16N2O5. Mole weight: 364.36. Purity: >95%. Properties: mp 268-270°C loss on drying <1%. Source : extracted from the nuts of the Camptotheca acuninata Decne. Reference: |  |
| (S)-10-Hydroxycamptothecin | (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis -inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 10-HCPT; 10-Hydroxycamptothecin. CAS No. 19685-09-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N0095. |  |
| 10-O-Methoxymethyl SN-38 | Protected Irinotecan metabolite. Group: Biochemicals. Alternative Names: 7-Ethyl-10-O-methoxymethyl-10-hydroxycamptothecin; 10-Hydroxy-10-O-methoxymethyl-7-ethylcamptothecin; 10-MOM SN-38; (4S)-4, 11-Diethyl-4-hydroxy-9-(methoxymethoxy)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 1246815-54-2. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Camptothecin | 10-hydroxycamptothecine precursor, topoisomerase inhibitor, binds irreversibly to DNA-topoisomerase I complex. CAS No. 7689-3-4. Product ID: 1-00921. Molecular formula: C20H16N2O4. Mole weight: 348.36. Purity: >99.0%. Properties: [a]D 31.3°. Reference: Biochem., 28, 4629, 1989. | |
| Silatecan | Silatecan (formerly AR-67) is a synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities. Silatecan DB-67 binds to and stabilizes the topoisomerase I-DNA covalent complex, inhibiting the religation of topoisomerase I-mediated single-stranded DNA breaks and producing lethal double-stranded DNA breaks when encountered by the DNA replication machinery; inhibition of DNA replication and apoptosis follow. Camptothecin readily undergoes hydrolysis at physiological pH, changing its conformation from the active lactone structure to an inactive carboxylate form. Modifications on the E ring of camptothecin prevent binding of human serum albumin, which prefers the inactive carboxylate form, thereby enhancing the stability of the active lactone structure and resulting in prolonged agent activity. In addition, this agent may radiosensitize tumor cells. Synonyms: AR-67; AR 67; AR67; DB-67; DB 67; DB67; 7-t-Butyldimethylsilyl-10-hydroxycamptothecin. Grades: >98%. CAS No. 220913-32-6. Molecular formula: C26H30N2O5Si. Mole weight: 478.62. | |
| 10-?Hydroxycamptothecin Acetate | 10-?Hydroxycamptothecin Acetate is a derivative of Camptothecin (C175150), an antitumor compound used in the treatment of hyperproliferative diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 951770-22-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C22H18N2O6, Molecular Weight: 406.39. US Biological Life Sciences. | Worldwide |
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