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| Product | Description | |
|---|---|---|
| LCL161 | LCL161 Inhibitor. Uses: Scientific use. Product Category: T2080. CAS No. 1005342-46-0. |  |
| LCL161 | LCL161 is a IAP inhibitor which inhibits XIAP in HEK293 cell and cIAP1 in MDA-MB-231 cell with IC 50 s of 35 and 0.4 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1005342-46-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15518. |  |
| LCL-161 | LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation. Synonyms: LCL161; LCL 161; LCL-161. CAS No. 1005342-46-0. Molecular formula: C26H33FN4O3S. Mole weight: 500.633. |  |
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