1009104 85 1 Suppliers USA
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Product | Description | |
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Smad3 inhibitor,sis3 Quick inquiry Where to buy Suppliers range | Smad3 inhibitor,sis3. Group: Heterocyclic Organic Compound. Grades: ≥90%. CAS No. 1009104-85-1. Product ID: ACM1009104851. Molecular formula: C28H27N3O3. Mole weight: 453.5. Appearance: Off-white solid. | |
Smad3 Inhibitor, SIS3 Quick inquiry Where to buy Suppliers range | Smad3 Inhibitor, SIS 3 is an inhibitor of SMAD3, which is a receptor-regulated intracellular protein that functions downstream of TGF-β as well as activin receptors and mediates their signaling. It plays an important role in cell proliferation, apoptosis, differentiation and formation of extracellular matrix. It is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts. Synonyms: 1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one. CAS No. 1009104-85-1. Molecular formula: C28H27N3O3. Mole weight: 453.542. |