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Product | Description | |
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MK-2206 Quick inquiry Where to buy Suppliers range | MK-2206 Inhibitor. Uses: Scientific use. Product Category: T1952. CAS No. 1032350-13-2. | |
MK-2206 (8-(4-(1-Aminocyclobutyl)phenyl-9-phenyl[1, 2, 4]triazolo[3, 4-f][1, 6]naphthyridin-3(2H)-one Dihydrochloride) Quick inquiry Where to buy Suppliers range | A highly selective non-ATP competitive allosteric Akt inhibitor with IC??s of 8nM, 2nM and 65nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr308 and Ser473 in 3T3-L1 adipocytes with IC?? values of 0.11 and 0.18uM, respectively as well as downstream effects of insulin on GLUT4 translocation (IC?? = 0.47uM) and glucose transport (IC?? = 0.14uM). In addition, treatment with MK-2206 causes a robust, concentration-dependent activation of autophagy in human glioma cell lines LN229 and T98G. Group: Biochemicals. Grades: Highly Purified. CAS No. 1032350-13-2. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
MK-2206 dihydrochloride Quick inquiry Where to buy Suppliers range | MK-2206 dihydrochloride. Group: Biochemicals. Alternative Names: 8-[4- (1-Aminocyclobutyl) phenyl]-9-phenyl-1, 2, 4-triazolo[3, 4-f][1, 6]naphthyridin-3 (2H) -one hydrochloride. Grades: Highly Purified. CAS No. 1032350-13-2. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C25H23Cl2N5O. US Biological Life Sciences. | Worldwide |
MK-2206 dihydrochloride Quick inquiry Where to buy Suppliers range | MK-2206 is a highly selective Akt inhibitor with IC50 of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. It is undergoing a phase II clinical trial for the treatment of ovarian, fallopian tube, or primary peritoneal cancer where there are mutations in P13K or AKT or low levels of PTEN. Synonyms: MK-2206. MK 2206. MK2206. Grades: >98%. CAS No. 1032350-13-2. Molecular formula: C25H23Cl2N5O. Mole weight: 480.4. |