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| Product | Description | |
|---|---|---|
| Fasudil | Fasudil is a potent and selective Rho-kinase (ROCK) inhibitor and vasodilator. ROCK is an enzyme that participates in vasoconstriction and vascular remodeling. Fasudil is used for the treatment of cerebral vasospasm and has the potential to treat pulmonary hypertension as well as certain memory loss. Uses: Protein kinase inhibitors. Synonyms: Fasudil; AT 877; AT-877; AT877; HA 1077; HA-1077; HA1077; 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline. Grades: >98%. CAS No. 103745-39-7. Molecular formula: C14H17N3O2S. Mole weight: 291.369. |  |
| Fasudil | Fasudil. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 8-((1,4-diazepan-1-yl)sulfonyl)isoquinoline. CAS No. 103745-39-7. Molecular Formula: C14H17N3O2S. Mole Weight: 291.37. Catalog: APB103745397. |  |
| HA1077 (Fasudil Dihydrochloride) | A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK).HA1077 is an inhibitor of ROK/ROCK II (IC50 1.9uM), PRK2 (IC50 4uM), MSK1 (IC50 5uM), Rsk2 (IC50 15uM), PKA, p70 S6 Kinase, CaM Kinase (Ki 1.8nM) and MLCK (Ki 20nM). HA1077 is a calcium antagonist and has antivasospastic properties. Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK. Group: Biochemicals. Alternative Names: Fasudil Dihydrochloride; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine 2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine 2HCl). Grades: Highly Purified. CAS No. 103745-39-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C14H17N3O2S 2HCl, Molecular Weight: 364.29. US Biological Life Sciences. |  Worldwide |
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