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| Product | Description | |
|---|---|---|
| IWR-1 | IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. Uses: Scientific research. Group: Signaling pathways. Alternative Names: endo-IWR 1; IWR-1-endo. CAS No. 1127442-82-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12238. |  |
| IWR-1-endo | IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Synonyms: IWR-1; IWR 1; IWR1; IWR-1-endo. Grades: >98%. CAS No. 1127442-82-3. Molecular formula: C25H19N3O3. Mole weight: 409.44. |  |
| IWR-1 (IWR-1-endo) | Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3 β. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3 β. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay). Group: Biochemicals. Alternative Names: 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide. Grades: Highly Purified. CAS No. 1127442-82-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O?, Molecular Weight: 409.4. US Biological Life Sciences. |  Worldwide |
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