1144035 53 9 Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor III, PF-8380, 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one) Quick inquiry Where to buy Suppliers range | An orally bioavailable piperazinyl benzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50=2.8 and 1.7nM for recombinant human enzyme-b isoform employing FS-3 and LPC (lysophosphatidyl choline) as substrates, respectively; 1.16 and 1.15nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30mg/kg, p.o.).CAS No:1144035-53-9. Group: Biochemicals. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
PF 8380 Quick inquiry Where to buy Suppliers range | PF 8380. Group: Biochemicals. Grades: Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
PF-8380 Quick inquiry Where to buy Suppliers range | PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM. Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. PF-8380 can serve as a tool compound for elucidating LPA's role in inflammation. Synonyms: 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester; PF8380; PF 8380; (3,5-Dichlorophenyl)methyl 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylate; 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester. Grades: ≥95%. CAS No. 1144035-53-9. Molecular formula: C22H21Cl2N3O5. Mole weight: 478.33. | |
PF8380 Quick inquiry Where to buy Suppliers range | PF8380. Group: Biochemicals. Alternative Names: 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic Acid 3,5-Dichlorobenzyl Ester; 4-[3-(2,3-Dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylic Acid (3,5-Dichlorophenyl)methyl Ester. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C22H21Cl2N3O5, Molecular Weight: 478.33. US Biological Life Sciences. | Worldwide |