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| Product | Description | |
|---|---|---|
| ALW-II-41-27 | ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor. pharmacologic inhibition of EPHA2 by the small-molecule inhibitor ALW-II-41-27 decreased both survival and proliferation of erlotinib-resistant tumor cells and inhibited tumor growth in vivo. ALW-II-41-27 was also effective in decreasing viability of cells with acquired resistance to the third-generation EGFR TKI AZD9291. Collectively, these data define a role for EPHA2 in the maintenance of cell survival of TKI-resistant, EGFR-mutant lung cancer and indicate that EPHA2 may serve as a useful therapeutic target in TKI-resistant tumors. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ALW-II-41-27; ALW II-41-27; ALWII-41-27; ALW-II-4127; ALW II-4127; ALWII-4127. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1186206-79-0. Molecular formula: C32H32F3N5O2S. Mole weight: 607.7. Purity: >98%. IUPACName: N-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)-5-(thiophen-2-yl)nicotinamide. Canonical SMILES: O=C(NC1=CC(C(NC2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)=CC=C1C)C4=CN=CC(C5=CC=CS5)=C4. Product ID: ACM1186206790. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ALW-II-41-27 | ALW-II-41-27 is an effective inhibitor of EPH family kinases that has been found to be related to lung cancers. IC50: 11 nM to EPHA2. Uses: Alw-ii-41-27 is an effective inhibitor of eph family kinases that is found to be related to lung cancers. Synonyms: ALW-II-41-27; ALW II-41-27; ALWII-41-27; ALW-II-4127; ALW II-4127; ALWII-4127; MLS002232274; CHEMBL556140; DTXSID80655254; BDBM163701. Grades: 98%. CAS No. 1186206-79-0. Molecular formula: C32H32F3N5O2S. Mole weight: 607.69. |  |
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