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12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons6 and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex. Synonyms: 12-Hydroperoxyicosatetraenoate; (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoic acid. Grades: ≥98%. CAS No. 71774-10-2. Molecular formula: C20H32O4. Mole weight: 336.5.
12(S)-HPETE
12(S)-HPETE is a fatty acid and an activator of human blood leukocyte 5-LO. Group: Biochemicals. Grades: Highly Purified. CAS No. 71774-10-2. Pack Sizes: 50ug, 100ug. Molecular Formula: C20H32O4, Molecular Weight: 336.47. US Biological Life Sciences.
Worldwide
(±)12-Hpete
(±)12-Hpete. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 12-HYDROPEROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID;(+/-)12-HPETE;12-Hydroperoxy-5,8,10,14-icosatetraenoic acid. Product Category: Heterocyclic Organic Compound. Appearance: A solution in ethanol. CAS No. 71030-35-8. Molecular formula: C20H32O4. Mole weight: 336.47. Purity: 0.96. Canonical SMILES: CCCCCC=CCC(C=CC=CCC=CCCCC(=O)O)OO. Product ID: ACM71030358. Alfa Chemistry ISO 9001:2015 Certified.
(+/-)12-HpETE
(+/-)12-HpETE is one of the six monohydroperoxy fatty acids and metabolite of arachidonic acid. Group: Biochemicals. Alternative Names: 12-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid. Grades: Highly Purified. CAS No. 71030-35-8. Pack Sizes: 25ug, 50ug, 100ug. Molecular Formula: C20H32O4, Molecular Weight: 336.47. US Biological Life Sciences.
Worldwide
15(S)-HPETE
15(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A41 or reduced to 15(S)-HETE by peroxidases.2,1 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1.3 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inactivation of porcine 12-LO. Uses: Scientific research. Group: Signaling pathways. CAS No. 70981-96-3. Pack Sizes: 25 μg (297.20 μM * 250 μL in Ethanol). Product ID: HY-113438.
CAY10698
Platelet-type 12-lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid, which has been found to be expressed in various tumor cells. CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 uM. It shows potenital applicaiton in biological characterization for development of potential 12-LO inhibitors. Synonyms: CAY 10698; CAY-10698. Grades: ≥98%. CAS No. 684236-01-9. Molecular formula: C17H17N3O4S2. Mole weight: 391.5.
hydroperoxy icosatetraenoate dehydratase
Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE). The enzymes also catalyse the reaction of EC 5.4.4.7, hydroperoxy icosatetraenoate isomerase. Group: Enzymes. Synonyms: epidermal lipoxygenase-3 (ambiguous); eLOX3 (ambiguous). Enzyme Commission Number: EC 4.2.1.152. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4993; hydroperoxy icosatetraenoate dehydratase; EC 4.2.1.152; epidermal lipoxygenase-3 (ambiguous); eLOX3 (ambiguous). Cat No: EXWM-4993.
hydroperoxy icosatetraenoate isomerase
Binds Fe2+. The enzyme from mammals accepts a range of hydroperoxyicosatetraenoates producing one or several different hydroxyepoxyicosatrienoates. The human enzyme has highest activity with (12R)-HPETE producing (5Z,8R,9E,11R,12R,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate, followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy-11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate. The mouse enzyme has highest activity with (8S)-HPETE, producing (5Z,8S,9S,10R,11Z,14Z)-10-hydroxy-8,9-epoxyicosa-5,11,14-trienoate. The enzymes also have the activity of EC 4.2.1.152, hydroperoxy icosatetraenoate dehydratase. Group: Enzymes. Synonyms: epidermal lipoxygenase-3 (ambiguous); eLOX3 (ambiguous). Enzyme Commission Number: EC 5.4.4.7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5548; hydroperoxy icosatetraenoate isomerase; EC 5.4.4.7; epidermal lipoxygenase-3 (ambiguous); eLOX3 (ambiguous). Cat No: EXWM-5548.
Native Glycine max (soybean) Lipoxidase
Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. Applications: The soybean enzyme will use arachidonic acid as a substrate, with ~ 15% of the activity indicated using linoleic acid as the substrate; the product of arachidonic acid oxidation is 12-or 15-hydroperoxyarachidonic acid (12-hpete or 15-hpete). Group: Enzymes. Synonyms: Lipoxygenases; EC 1.13.11.12; 9029-60-1; 13-lipoxidase; carotene oxidase; 13-lipoperoxidase; fat oxidase; 13-lipoxydase; lionoleate:O2 13-oxidoreductase; linoleate 13S-lipoxygenase. Enzyme Commission Number: EC 1.13.11.12. CAS No. 9029-60-1. Lipoxygenase. Mole weight: mol wt 108 kDa (two 54 kDa subunits). Activity: Type I, 500,000-1,000,000 units/mg protein; Type II, > 50,000 units/mg solid. Storage: 2-8°C. Form: Type I, ammonium sulfate suspension, Suspension in 2.3 M (NH4)2SO4 solution, pH approx. 6.0; Type II, lyophilized powder, Contains stabilizer and NaCl. Source: Glycine max (soybean). Lipoxygenases; EC 1.13.11.12; 9029-60-1; 13-lipoxidase; carotene oxidase; 13-lipoperoxidase; fat oxidase; 13-lipoxydase; lionoleate:O2 13-oxidoreductase; linoleate 13S-lipoxygenase. Cat No: NATE-0407.
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