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| Product | Description | |
|---|---|---|
| NMS-P715 | NMS-P715 was found to be highly specific for MPS1, with no other kinases inhibited below an IC50 value of 5 mmol/L and with only 3 kinases inhibited below 10 mmol/L (CK2, MELK, and NEK6), which were not significantly affected by compound preincubation. NMS-P715 promotes massive SAC override with a half-maximal effective concentration (EC50) of 65 nmol/L. NMS-P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumoral cell lines and inhibits tumor growth in preclinical cancer models. Synonyms: NMS P715; NMS-P 715. Grades: >98%. CAS No. 1202055-32-0. Molecular formula: C35H39F3N8O3. Mole weight: 676.73. |  |
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