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| Product | Description | |
|---|---|---|
| LY2801653 dihydrochloride | LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (K(I)) of 2 nM, a pharmacodynamic residence time (K(off)) of 0.00132 min(-1) and t(1/2) of 525 min [1]. LY2801653 was found to have potent activity against several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, DDR1/2 and against the serine/threonine kinases MKNK1/2. LY2801653 demonstrated in vitro effects on MET pathway-dependent cell scattering and cell proliferation; in vivo anti-tumor effects in MET amplified (MKN45), MET autocrine (U-87MG, and KP4) and MET over-expressed (H441) xenograft models; and in vivo vessel normalization effects. Synonyms: LY-2801653 dihydrochloride; LY 2801653 dihydrochloride. Grades: >98%. CAS No. 1206801-37-7. Molecular formula: C30H24Cl2F2N6O3. Mole weight: 625.45. |  |
| Merestinib dihydrochloride | Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor ( K i =2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC 50 =11 nM), FLT3 (IC 50 =7 nM), AXL (IC 50 =2 nM), MERTK (IC 50 =10 nM), TEK (IC 50 =63 nM), ROS1, DDR1/2 (IC 50 =0.1/7 nM) and MKNK1/2 (IC 50 =7 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY2801653 dihydrochloride. CAS No. 1206801-37-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15514A. |  |
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