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| Product | Description | |
|---|---|---|
| Gemilukast | This active molecular is an potent dual Leukotriene CysLT1 and CysLT2 Receptor antagonist originated by Ono Pharmaceutical. IC50 values is 1.7nM against human CysLT1 and 25 nM against human CysLT2. Gemilukast reduced LTC4-induced bronchoconstriction in asthmatic animal models dose-dependently. In addition, it can also reduceantigen-induced constriction of isolated human bronchi. In 2015, Phase-II clinical trials in Asthma in Japan and USA was on-going. Uses: Asthma. Synonyms: ONO6950; ONO 6950; ONO-6950;4,4'-(4-fluoro-7-((4-(4-(3-fluoro-2-methylphenyl)butoxy)phenyl)ethynyl)-2-methyl-1H-indole-1,3-diyl)dibutyric acid;1232861-64-1 (disodium salt); 1232873-69-6 (8 hydrate and disodium salt). Grades: 98%. CAS No. 1232861-58-3. Molecular formula: C36H37F2NO5. Mole weight: 601.69. |  |
| Gemilukast disodium salt | Gemilukast, also known as ONO-6950, is an orally active dual CysLT1 and CysLT2 antagonist. Gemilukast exhibited antagonist activities with IC50 values of 1.7 and 25 nM against human CysLT1 and human CysLT2, respectively. Synonyms: 1H-Indole-1,?3-dibutanoic acid, 4-fluoro-7-[2-[4-[4- (3-fluoro-2-methylphenyl) ?butoxy]?phenyl]?ethynyl]?-2-methyl-, sodium salt (1:2). Grades: 98%. CAS No. 1232861-64-1. Molecular formula: C36H37F2NO5.2Na. Mole weight: 647.67. | |
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