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| Product | Description | |
|---|---|---|
| PI4KIII β inhibitor 3 | The most effective test compound, the compound of formula 3 (PI4KIII beta inhibitor 3), inhibited IL2 and IFNy secretion with IC50 values of less than 1 nM in each case. Thus, the compound of formula (3) was shown to be as effective at inhibiting IL2 and IFNy secretion as conventional immunosuppressants such as cyclosporine A. IC50 on IFNy and IL-2 release of Cyclosporine A are 2nM and less than 1 nM respectively. Twelve animals received daily treatment with vehicle (1%methylcellulose), twelve others received PI4KIII beta inhibitor 3 at 40 mg/kg/d in 1% methylcellulose. Synonyms: PI4KIII beta inhibitor 3. Grades: >98%. CAS No. 1245319-54-3. Molecular formula: C22H22N8OS. Mole weight: 446.53. |  |
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