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| Product | Description | |
|---|---|---|
| MK-7145 | This active molecular is a selective renal outer medullary potassium channel (RMOK) inhibitor originated by Merck Sharp & Dohme for the treatment of hypertension and heart failure. RMOK is an ATP-dependent potassium channel that transports potassium out of cells. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 with IC50 value > 30 μM. MK-7145 is the first small molecule ROMK inhibitor to enter clinical development. But in Feb 2015, Merck terminated a phase I trial in Hypertension in Australia and New Zealand. Uses: Hypertension and heart failure. Synonyms: MK-7145; MK 7145; MK7145; 5,5'-((1R,1'R)-piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl))bis(4-methylisobenzofuran-1(3H)-one);1255204-85-3 (2HCl). Grades: 98%. CAS No. 1255204-84-2. Molecular formula: C26H30N2O6. Mole weight: 466.53. |  |
| MK-7145 dihydrochloride | MK-7145 is a potent, selective and orally active ROMK inhibitor for the treatment of hypertension and heart failure. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50 > 30 μM). Synonyms: MK-7145 dihydrochloride; MK 7145 dihydrochloride; MK7145 dihydrochloride. Grades: 98%. CAS No. 1255204-85-3. Molecular formula: C26H30N2O6.2HCl. Mole weight: 544.534. | |
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