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| Product | Description | |
|---|---|---|
| KN62 | KN62 is a P2X7R antagonist (hP2X7 IC50=51 nM) and Ca2+/calmodulin-dependent protein kinase II inhibitor. KN62 inhibits the invasiveness of cancer cells in vitro and in vivo KN62 causes retrograde amnesia in the rat. KN62 attenuates glutamate release by inhibiting voltage-dependent Ca(2+)-channels. The effect of KN62 on Ca(2+)-influx appears to be specific to slowly-or non-inactivating conductances, and therefore presents KN62 as a potentially useful tool. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KN62; KN-62; KN 62. Product Category: Antagonists. Appearance: Solid powder. CAS No. 127191-97-3. Molecular formula: C38H35N5O6S2. Mole weight: 721.85. Purity: >98%. IUPACName: (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate. Canonical SMILES: CN([C@@H](CC1=CC=C(OS(=O)(C2=C3C(C=NC=C3)=CC=C2)=O)C=C1)C(N4CCN(C5=CC=CC=C5)CC4)=O)S(C6=CC=CC7=C6C=CN=C7)(=O)=O. Product ID: ACM127191973. Alfa Chemistry ISO 9001:2015 Certified. |  |
| KN 62 | 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester C38H35N5O6S2Fw 721.88 98% white solid, selectively inhibits rat brain, Ca2+/cadmodulin-dependent protein kinase II, soluble in DMSO, MeOH. selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II. CAS No. 127191-97-3. Product ID: 1-01108. Molecular formula: C38H35N5O6S2. Mole weight: 721.88. Purity: 0.98. Properties: white solid, soluble in DMSO, MeOH, 4°C. Reference: J. Biol. Chem., 267, 12511, 1992; J. Biol. Chem., 265, 4315, 1990. Categories: KN-62. |  |
| KN-62 | KN-62. Group: Biochemicals. Grades: Purified. CAS No. 127191-97-3. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| KN-62 | KN-62 suppresses the A23187-induced autophosphorylation of Ca2+/CaM kinase in PC12 D cells. Uses: Enzyme inhibitors. Synonyms: KN-62; KN 62; KN62. Grades: >98%. CAS No. 127191-97-3. Molecular formula: C38H35N5O6S2. Mole weight: 721.84. |  |
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