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| Product | Description | |
|---|---|---|
| KN-62 - CAS 127191-97-3 | A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Group: Fluorescence/luminescence spectroscopy. |  |
| KN62 | KN62 is a P2X7R antagonist (hP2X7 IC50=51 nM) and Ca2+/calmodulin-dependent protein kinase II inhibitor. KN62 inhibits the invasiveness of cancer cells in vitro and in vivo KN62 causes retrograde amnesia in the rat. KN62 attenuates glutamate release by inhibiting voltage-dependent Ca(2+)-channels. The effect of KN62 on Ca(2+)-influx appears to be specific to slowly-or non-inactivating conductances, and therefore presents KN62 as a potentially useful tool. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KN62; KN-62; KN 62. Product Category: Antagonists. Appearance: Solid powder. CAS No. 127191-97-3. Molecular formula: C38H35N5O6S2. Mole weight: 721.85. Purity: >98%. IUPACName: (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate. Canonical SMILES: CN([C@@H](CC1=CC=C(OS(=O)(C2=C3C(C=NC=C3)=CC=C2)=O)C=C1)C(N4CCN(C5=CC=CC=C5)CC4)=O)S(C6=CC=CC7=C6C=CN=C7)(=O)=O. Product ID: ACM127191973. Alfa Chemistry ISO 9001:2015 Certified. |  |
| KN-62 | KN-62. Group: Biochemicals. Grades: Purified. CAS No. 127191-97-3. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
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