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| Product | Description | |
|---|---|---|
| H 89 | Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM. Synonyms: Protein kinase inhibitor H-89; H89; H 89. Grades: >98%. CAS No. 127243-85-0. Molecular formula: C20H20BrN3O2S. Mole weight: 446.36. |  |
| H-89 dihydrochloride (N-5-isoquinolinesulfonamid e . 2HCl) | Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cµ (PKCµ) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H20BrN3O2S. 2HCl, Molecular Weight: 519.3. US Biological Life Sciences. |  Worldwide |
| H-89 Dihydrochloride (PKA Inhibitor III, N- [2- ( (p-Bromocinnamyl ) amino) ethyl ]-5-isoquinolinesulfonamid e , 2HCl) | A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48nM). Inhibits other kinases only at much higher concentrations: CaM kinase II (Ki = 29.7uM), casein kinase I (Ki = 38.3uM), myosin light chain kinase (Ki = 28.3uM), protein kinase C (Ki = 31.7uM), and ROCK-II (IC50 = 270nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs) such as GEFI, GEFII, or Epac (exchange protein directly activated by cAMP). Enhances radiation-induced apoptosis in the human cell line BM 13674. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-[2- (p-Bromocinnamylamino) ethyl]-5-isoquinoline sulfonamide | N-[2- (p-Bromocinnamylamino) ethyl]-5-isoquinoline sulfonamide. Group: Biochemicals. Alternative Names: N- [2- [ [3- (4-Bromophenyl ) -2-propen-1-yl ] amino] ethyl ] -5-isoquinolinesulfonamid e ; H-89. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C20H20BrN3O2S. US Biological Life Sciences. | Worldwide |
| N-[2-(p-Bromocinnamylamino)ethyl]-5-Isoquinoline Sulfonamide, 98% | N-[2-(p-Bromocinnamylamino)ethyl]-5-Isoquinoline Sulfonamide, 98%. Group: other glass and ceramic materials. CAS No. 127243-85-0. Product ID: N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide. Molecular formula: 446.4g/mol. Mole weight: C20H20BrN3O2S. C1=CC2=C (C=CN=C2)C (=C1)S (=O) (=O)NCCNCC=CC3=CC=C (C=C3)Br. InChI=1S/C20H20BrN3O2S/c21-18-8-6-16 (7-9-18)3-2-11-22-13-14-24-27 (25, 26)20-5-1-4-17-15-23-12-10-19 (17)20/h1-10, 12, 15, 22, 24H, 11, 13-14H2/b3-2+. ZKZXNDJNWUTGDK-NSCUHMNNSA-N. |  |
| Protein Kinase Inhibitor H-89 (PKI, N- (2-p-bromocinnamyl aminoeth yl ]-5-isoquinolinesulfonamid e ) (N- (2-p-bromocinnamyl aminoeth yl ]-5-isoquinolinesulfonamid e ) | Protein Kinase Inhibitors. Group: Biochemicals. Grades: Molecular Biology Grade. CAS No. 127243-85-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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