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| Product | Description | |
|---|---|---|
| Bizelesin | Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. Uses: Antineoplastic agents, alkylating. Synonyms: U-77779; U 77779; U77779; NSC-615291; N,N'-Bis[2-[[(1S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]urea. CAS No. 129655-21-6. Molecular formula: C43H36Cl2N8O5. Mole weight: 815.71. |  |
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