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| Product | Description | |
|---|---|---|
| MG-132 | MG-132 Inhibitor. Uses: Scientific use. Product Category: T2154. CAS No. 133407-82-6. |  |
| MG-132 | MG-132 is a potent Proteasome inhibitor with potential anticancer activity. MG-132 induces MCPIP1 expression; induces C6 glioma cell apoptosis via oxidative stress; induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway. Synonyms: Z-Leu-leu-leu-al. CAS No. 133407-82-6. Molecular formula: C26H41N3O5. Mole weight: 475.62. |  |
| MG-132 | MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC 50 s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Z-Leu-Leu-Leu-al; MG132. CAS No. 133407-82-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13259. |  |
| MG-132 (Z-Leu-Leu-Leu-CHO) | Potent, cell permeable and selective, reversible proteasome inhibitor. Blocks degradation of short-lived proteins and induces a heat shock response. NF-kB activation inhibitor through IκB degradation. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin inhibitor. Has anticancer properties by inducing cell cycle arrest and activating apoptosis in various cancer cell lines. Has adjuvant / chemosensitizer potential. Neurite outgrowth stimulator in PC12 cells. Prevents beta-secretase cleavage. Autophagy activator. Group: Biochemicals. Alternative Names: Z-Leu-Leu-Leu-al; Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal; Proteasome Inhibitor XI). Grades: Highly Purified. CAS No. 133407-82-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C26H41N3O5, Sequence: Z-Leu-Leu-Leu-aldeyhde. US Biological Life Sciences. |  Worldwide |
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