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| Product | Description | |
|---|---|---|
| Epoxomicin | Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy. Group: Biochemicals. Alternative Names: N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1- [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide, BU 4061T. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 100ug, 250ug, 500ug. Molecular Formula: C??H??N?O?, Molecular Weight: 554.7. US Biological Life Sciences. |  Worldwide |
| Epoxomicin | Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: BU-4061T. CAS No. 134381-21-8. Pack Sizes: 10 mM * 1 mL; 100 μg; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-13821. |  |
| Epoxomicin | Epoxomicin is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. Uses: Proteasome inhibitors. Synonyms: BU-4061T. Grades: >98%. CAS No. 134381-21-8. Molecular formula: C28H50N4O7. Mole weight: 554.72. |  |
| Epoxomicin (BU-4061T, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1 [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide) | Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin. Blocks also trypsin-like and PGPH activities of the proteasome. Group: Biochemicals. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 250ug. US Biological Life Sciences. | Worldwide |
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