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| Product | Description | |
|---|---|---|
| Nrf2 Activator III, TAT-14 Peptide, H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH | A 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75uM). Also shown to suppress LPS-induced TNF-a secretion in THP-1 monocytes (~ 37.5uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 1362661-34-4. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| TAT 14 | TAT 14. Group: Biochemicals. Grades: Purified. CAS No. 1362661-34-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TAT 14 | TAT 14 is an Nrf2 activator and inhibits Nrf2/Keap1 interaction with neuroprotective activity. TAT 14 has been shown to induce upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1 and suppress LPS-induced TNF-α expression in THP-1 cells. Synonyms: TAT14; TAT-14; H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-leucyl-L-glutaminyl-L-leucyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-threonyl-glycyl-L-alpha-glutamyl-L-phenylalanyl-L-leucyl-L-prolyl-L-isoleucyl-L-glutamine; TAT 14 Peptide (Nrf2 Activator III). Grades: ≥95%. CAS No. 1362661-34-4. Molecular formula: C137H230N48O39. Mole weight: 3173.59. |  |
| TAT-14 | TAT-14 is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect. TAT-14 has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1 [1]. Uses: Scientific research. Group: Peptides. CAS No. 1362661-34-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1328. |  |
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