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| Product | Description | |
|---|---|---|
| Ceritinib dihydrochloride | Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC 50 of 200 pM. Ceritinib dihydrochloride (LDK378 dihydrochloride) also inhibits IGF-1R , InsR , and STK22D with IC 50 values of 8, 7, and 23 nM, respectively. Ceritinib dihydrochloride (LDK378 dihydrochloride) shows great antitumor potency [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LDK378 dihydrochloride. CAS No. 1380575-43-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15656A. |  |
| LDK378 dihydrochloride | Ceritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib. LDK378 blocks the ALK protein and stops it sending growth signals to cancer cells, which may stop them growing. Synonyms: LDK 378 dihydrochloride; LDK-378 dihydrochloride; LDK378 dihydrochloride; Ceritinib dihydrochloride. Grades: >98%. CAS No. 1380575-43-8. Molecular formula: C28H38Cl3N5O3S. Mole weight: 631.06. |  |
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