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| Product | Description | |
|---|---|---|
| WHI-P180 hydrochloride | WHI-P180 moderately inhibited ABCG2 function, exhibiting weak phototoxicity. The elimination half-life of WHI-P180 in CD-1 mice (BALB/ c mice) following i.v., i.p., or p.o. administration was less than 10 min. Systemic clearance of WHI-P180 was 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibited IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis. Synonyms: Janex 3 hydrochloride; Janex3 hydrochloride; Janex-3 hydrochloride; WHI-P 180 hydrochloride; WHIP 180 hydrochloride; WHI P 180 hydrochloride. Grades: >98%. CAS No. 153437-55-9. Molecular formula: C16H16ClN3O3. Mole weight: 333.77. |  |
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