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| Product | Description | |
|---|---|---|
| Metanicotine | Metanicotine. Group: Biochemicals. Alternative Names: (E)-N-[Methyl]-4-(3-pyridinyl)-3-buten-1-amine, RJR 2403; Rivanicline; (E)-Metanicotine. Grades: Highly Purified. CAS No. 15585-43-0. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C10H14N2. US Biological Life Sciences. |  Worldwide |
| RJR-2403 | At concentrations up to 1 mM, RJR-2403 does not significantly activate nAChRs in PC12 cells, muscle type nAChRs or muscarinic receptors. Dose-response curves for agonist-induced ileum contraction indicate that RJR-2403 is less than one-tenth as potent as nicotine with greatly reduced efficacy. RJR-2403 does not antagonize nicotine-stimulated muscle or ganglionic nAChR function (IC50 > 1 mM). Chronic exposure of M10 cells to RJR-2403 (10 microM) results in an up-regulation of high-affinity nAChRs phenomenologically similar to that seen with nicotine. RJR-2403 significantly improved passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats with ibotenic acid lesions of the forebrain cholinergic projection system in an 8-arm radial maze paradigm. By comparison, RJR-2403 was 15 to 30-fold less potent than nicotine in decreasing body temperature, respiration, Y-maze rears and crosses and acoustic startle response. Metanicotine was about 5-fold less potent than nicotine in the tail-flick test after s.c administration, but slightly more potent after central administration. Synonyms: Rivanicline; Metanicotine; RJR-2403; RJR 2403; RJR2403; Metanicotine; Rivanicline oxalate. Grades: >98%. CAS No. 15585-43-0. Molecular formula: C10H14N2. Mole weight: 162.23. |  |
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