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| Product | Description | |
|---|---|---|
| PT2385 | PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor PT2385 allosterically binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Group: Inhibitors. Alternative Names: PT2385; PT-2385; PT 2385. CAS No. 1672665-49-4. Molecular formula: C17H12F3NO4S. Mole weight: 383.34. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile. Canonical SMILES: CS (C (C=C1)=C2C (CC (F) (F)[C@H]2O)=C1OC3=CC (C#N)=CC (F)=C3) (=O)=O. Catalog: ACM1672665494. |  |
| PT-2385 | PT-2385 is a small molecule inhibitor with oral activity that inhibits hypoxia inducible factor (HIF)-2alpha heterodimerization and its subsequent binding to DNA by binding to HIF-2alpha. Synonyms: 3-[[(1S)-2,2-difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrilePT-2385; PT2385; PT 2385SCHEMBL165558103-{[(1s)-2,2-Difluoro-1-Hydroxy-7-(Methylsulfonyl)-2,3-Dihydro-1h-Inden-4-Yl]oxy}-5-Fluorobenzonitrile79A. CAS No. 1672665-49-4. Molecular formula: C17H12F3NO4S. Mole weight: 383.34. |  |
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