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| Product | Description | |
|---|---|---|
| Rineterkib | Rineterkib is a RAF and ERK1/2 inhibitor developed for the treatment of proliferative diseases characterized by activating mutations in the MAPK pathway. Synonyms: ERK-IN-1; LTT-462. CAS No. 1715025-32-3. Molecular formula: C26H27BrF3N5O2. Mole weight: 578.4. |  |
| Rineterkib free base | Rineterkib, also known as LTT-462 or ERK-IN-1, is a ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models. LTT462 binds to and inhibits ERK, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in numerous tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Rineterkib; ERK-IN-1; ERK IN 1; ERK IN-1; ERK-IN 1; LTT 462; LTT-462; LTT462. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1715025-32-3. Molecular formula: C26H27BrF3N5O2. Mole weight: 578.43. Purity: >98%. IUPACName: 4-{3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]pyrazin-2-yl}-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluorobenzamide. Canonical SMILES: O=C(N[C@@H](C1=CC(F)=CC(Br)=C1)CNC)C2=CC=C(C3=NC([C@@H]4C[C@H](F)[C@@H](O)CC4)=CN=C3N)C=C2F. Product ID: ACM1715025323. Alfa Chemistry ISO 9001:2015 Certified. |  |
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