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RN 1 dihydrochloride RN 1 is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM), which exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50= 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). It blocks long-term but not short-term memory in mice following intraperitoneal administration. RN-1 also induces cytotoxicity in ovarian cancer cell lines and induces fetal hemoglobin synthesis while reducing disease pathology in sickle cell mice. Synonyms: RN 1 dihydrochloride; RN-1 dihydrochloride; RN1 dihydrochloride; 1- (4-methyl-1-piperazinyl) -2-[[ (1R*, 2S*) -2-[4-phenylmethoxy) phenyl]cyclopropyl]amino]ethanone dihydrochloride; RN-1, monohydrochloride; RN-1 2HCl. Grades: ≥97% by HPLC. CAS No. 1781835-13-9. Molecular formula: C23H29N3O2.2HCl. Mole weight: 452.42. BOC Sciences 9
RN-1 dihydrochloride RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC 50 of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC 50 values of 0.51 μM and 2.785 μM respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1781835-13-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-110130. MedChemExpress MCE

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