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| Product | Description | |
|---|---|---|
| Bortezomib | Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome ( K i =0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PS-341; LDP-341; NSC 681239. CAS No. 179324-69-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10227. |  |
| Bortezomib, Free Base (Velcade, MG-341, PS-341, [ (1S) -3-methyl-1- [ [ (2R) -3-phenyl-2- (pyrazine-2-carbonylamino) propanoyl] amino] butyl] boronic Acid) | Bortezomib is the active ingredient in the drug sold under the trade name Velcade®. This drug has been approved in at least one country to treat multiple myeloma. It is a potent (Ki, 0.6nM), specific and reversible proteasome inhibitor. There is not any significant inhibitory activity against other enzymes or receptors. In a study with the National Cancer Institute's panel of 60 human cell lines, Bortezomib showed a mean IC50 of 7nM as tested by SRB analysis. Group: Biochemicals. Grades: Highly Purified. CAS No. 179324-69-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences. |  Worldwide |
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