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| Product | Description | |
|---|---|---|
| Ethynylcytidine | Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. 3'-C-ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis. RNase L is a potent antiviral and antiproliferative endoribonuclease that cleaves singled stranded RNA, causes 28s rRNA fragmentation, and activates Janus Kinase (JAK), a mitochondrial-dependent apoptosis signaling molecule. Synonyms: ECyd; TAS-106; TAS 106; TAS106; 3'-C-Ethynylcytidine; AIDS241582; AIDS 241582; AIDS-241582; SB-596168; SB596168; SB 596168; 3'-Ethynylcytidine. CAS No. 180300-43-0. Molecular formula: C11H13N3O5. Mole weight: 267.241. |  |
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