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| Product | Description | |
|---|---|---|
| Gefitinib | 100mg Pack Size. Group: Bioactive Small Molecules, Biochemicals, Research Organics & Inorganics. Formula: C22H24ClFN4O3. CAS No. 184475-35-2. Prepack ID 57220562-100mg. Molecular Weight 446.9. See USA prepack pricing. |  |
| Gefitinib | Gefitinib. Group: Biochemicals. Grades: Highly Purified. CAS No. 184475-35-2. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C22H24ClFN4O3. US Biological Life Sciences. |  Worldwide |
| Gefitinib | Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Synonyms: ZD1839; ZD 1839; ZD-1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine; Iressa; gefitinibum. Grade: >98%. CAS No. 184475-35-2. Molecular formula: C22H24ClFN4O3. Mole weight: 446.90. |  |
| Gefitinib | Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC 50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC 50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy and cell apoptosis , which can be used for cancer related research, such as Lung cancer and breast cancer [1] [2] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZD1839. CAS No. 184475-35-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-50895. |  |
| Gefitinib, Free Base (Iressa) | EGFR tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme. The functions of the EGFR tyrosine kinase in activating the Ras signal transduction cascade and malignant cell growth are thus inhibited. It has been shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways in gefitinib-sensitive non-small cell lung cancers. These mutations tend to increase sensitivity to tyrosine kinase inhibitors including gefitinib and erlotinib. The adenocarcinoma subset of non-small cell lung cancer histologies often have these mutations, which are commonly found in Asians, women, and non-smokers. Group: Biochemicals. Grades: Highly Purified. CAS No. 184475-35-2. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Gefitinib (Iressa) | Gefitinib (Iressa). Group: Biochemicals. Alternative Names: Iressa. Grades: Highly Purified. CAS No. 184475-35-2. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
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