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Cortistatin-17, a structural analogue of somatostatin, binds to all somatostatin receptor subtypes (SSTR) in a manner similar to rat cortistatin. Its inhibition on the cAMP production of forskolin-stimulated in chinese hamster ovary cells expressing SSTR2-5 are dose-dependent, but slightly less efficient than somatostatin-14. Like rat cortistatin, it affects sleep and wake patterns in rats. It reduces light slow wave sleep (SWS1) and increases deep slow wave sleep (SWS2) in a dose-dependent manner. Administration of the peptide causes a temporary flattening of cortical and hippocampal electroencephalograms. Synonyms: H-Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (Disulfide bridge: Cys5-Cys16); L-alpha-aspartyl-L-arginyl-L-methionyl-L-prolyl-D-cysteinyl-D-arginyl-L-asparagyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-D-phenylalanyl-D-seryl-L-seryl-L-cysteinyl-L-lysine (5->16)-disulfide; L-α-Aspartyl-L-arginyl-L-methionyl-N-[(4R, 7S, 10R, 13R, 16S, 19S, 22R, 25S, 28S, 31S, 34R, 37S)-19-(4-aminobutyl)-4-{[(1S)-5-amino-1-carboxypentyl]carbamoyl}-31-(2-amino-2-oxoethyl)-13, 25, 28-tribenzyl-34-(3-carbamimidamidopropyl)-16-[(1R)-1-hydroxyethyl]-7, 10-bis(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36-undecaoxo-1, 2-dithia-5, 8, 11, 14, 17, 20, 23, 26, 29, 32, 35-undecaazacyclooctatriacontan-37-yl]-L-prolinamide. Grades: 95%. CAS No. 189450-19-9. Molecular formula: C96H139N27O24S3. Mole weight: 2151.53.
L-Lysine, L-a-aspartyl-L-arginyl-L-methionyl-L-prolyl-L-cysteinyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-seryl-L-seryl-L-cysteinyl-,cycl. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ASP-ARG-MET-PRO-CYS-ARG-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS;H-ASP-ARG-MET-PRO-CYS-ARG-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS-OH;CORTISTATIN-17 (HUMAN);H-Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH, (Disulfide bond). Product Category: Heterocyclic Organic Compound. CAS No. 189450-19-9. Molecular formula: C96H139 N27 O24 S3. Mole weight: 2153.51. Product ID: ACM189450199. Alfa Chemistry ISO 9001:2015 Certified.
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