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| Product | Description | |
|---|---|---|
| 2-Arachidonoylglycerol | 2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 25.3-472 and 145-1,400 nM, respectively). Synonyms: 2-AG; 2-Arachidonoyl Glycerol; glyceryl 2-arachidonate; 2-Ara-Gl; MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0); 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol. Grade: >99%. CAS No. 53847-30-6. Molecular formula: C23H38O4. Mole weight: 378.55. |  |
| 2-Arachidonoylglycerol | 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand in the central nervous system. Uses: Scientific research. Group: Natural products. CAS No. 53847-30-6. Pack Sizes: 1 mg (26.4 mM * 100 μL in Acetonitrile). Product ID: HY-W011051. |  |
| 1-Monoarachidin | 1-Monoarachidin is a derivative of 2-Arachidonoylglycerol (A765050), an major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. Group: Biochemicals. Alternative Names: 1-Monoarachidonoyl-rac-glycerol; (all-Z)-(±)-2,3-Dihydroxypropyl 5,8,11,14-eicosatetraenoate; (all-Z)-5,8,11,14-Eicosatetraenoic Acid, 2,3-Dihydroxypropyl Ester; (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid, 2,3-Dihydroxypropyl Ester. Grades: Highly Purified. CAS No. 35474-99-8. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| 2-Arachidonyl Glycerol-[d5] | Labelled 2-Arachidonoylglycerol. 2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 25.3-472 and 145-1,400 nM, respectively). Synonyms: (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid 2-Hydroxy-1-(hydroxymethyl) ethyl-d5 Ester; (all-Z)-5,8,11,14-Eicosatetraenoic Acid 2-Hydroxy-1-(hydroxymethyl)ethyl-d5 Ester; 2-Monoarachidonoylglycerol-d5. Grade: 95%. CAS No. 1215168-37-8. Molecular formula: C23H33D5O4. Mole weight: 383.57. | |
| 2-Linoleoyl glycerol | 2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Monolinolein; 2-Monolinoleoylglycerol. CAS No. 3443-82-1. Pack Sizes: 500 μg (14.10 mM * 100 μL in Methyl acetate); 1 mg (14.10 mM * 200 μL in Methyl acetate). Product ID: HY-130311. | |
| 2-Palmitoylglycerol | 2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119 [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Palm-Gl. CAS No. 23470-00-0. Pack Sizes: 25 mg; 50 mg; 5 mg; 10 mg. Product ID: HY-W013788. | |
| (3S,4S)-3-Hexyl-4-[(2S)-2-hydroxytridecyl]-2-oxetanone | (3S,4S)-3-Hexyl-4-[(2S)-2-hydroxytridecyl]-2-oxetanone is an analog of Tetrahydrolipstatin, an inhibitor of the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG), also an intermediate in the preparation of Orlistat. Group: Biochemicals. Alternative Names: [3S-[3α,4 β(R*)]]-3-Hexyl-4-(2-hydroxytridecyl)-2-oxetanone; (3S,4S)-3-Hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. Grades: Highly Purified. CAS No. 68711-40-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (3S, 4S) -3-Hexyl-4[ (S) -2- (triisopropylsilyloxy) tridecyl]-2-oxetanone | A reagent used in the synthesis of enzymatic endocannabinoid 2-arachidonoylglycerol hydrolysis inhibitors and respective analogs. Group: Biochemicals. Alternative Names: (3S,4S)-. Grades: Highly Purified. CAS No. 1072902-84-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (5Z,8Z,11Z,14Z)-2-[[Tris(1-methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris (1-methylethyl) silyl]oxy]methyl]ethyl Ester | (5Z,8Z,11Z,14Z)-2-[[Tris(1-methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris (1-methylethyl) silyl]oxy]methyl]ethyl Ester is an intermediate in the synthesis of 2-Arachidonoylglycerol (A765050), an major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 223259-26-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Arachidonoyl serinol | Arachidonoyl Serinol is an amide bond-containing analogue of 2-arachidonoylglycerol, which exhibited weak CB1 receptor agonistic activity. 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain. It is a product of increased inositol phospholipid metabolism. Replacement of the sn-2 oxygen in the glycerol moiety of 2-AG with a nitrogen atom gives arachidonoyl serinol. Arachidonoyl serinol is much more stable than 2-AG. Synonyms: N-arachidonoyl dihydroxypropylamine; 183718-70-9; AA dihydroxypropylamine; (5Z,8Z,11Z,14Z)-N-(1,3-dihydroxypropan-2-yl)icosa-5,8,11,14-tetraenamide; CHEMBL141463; Arachidonoyl Serinol; N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(1,3-dihydroxy-propyl-2-amine); 5,8,11,14-Eicosatetraenamide,N-[2-hydroxy-1-(hydroxymethyl)ethyl]-, (5Z,8Z,11Z,14Z)-; N-[(2-Hydroxy-1-hydroxymethyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; Arachidonoylserinol; CHEBI:183197; QHELXIATGZYOIB-DOFZRALJSA-N; HMS3649C07; BDBM50054465; LMFA08020072; SR-01000946557; SR-01000946557-1; (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid (2-hydroxy-1-hydroxymethyl-ethyl)-amide. Grade: ≥98%. CAS No. 183718-70-9. Molecular formula: C23H39NO3. Mole weight: 377.6. | |
| CAY10499 | Monoglyceride lipase (MGL) plays an important role in the metabolism of the lipid transmitter 2-arachidonoylglycerol (2-AG). CAY10499 is a potent and selective monoglyceride lipase (MGL) inhibitor exhibiting an IC50 of 90 nM for the recombinant enzyme. It is also a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 mM, respectively). Synonyms: CAY-10499; CAY 10499; Magl-IN-5. Grade: ≥98%. CAS No. 359714-55-9. Molecular formula: C18H17N3O5. Mole weight: 355.34. | |
| JZL 184 | JZL 184 is a potent, selective and irreversible MAGL inhibitor that blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes (IC50 of 8 nM). JZL 184 displays >300-fold selectivity for MAGL over FAAH[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1101854-58-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-15249. | |
| KT109 | KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC 50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGL&alpha. KT109 shows inhibitory activity against PLA2G7 (IC 50 =1 μM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402612-55-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18540. | |
| MJN110 | MJN110 is an orally active and selective monoacylglycerol lipase (MAGL) inhibitor with IC50s of 9.1 nM and 2.1 nM for hMAGL and 2-arachidonoylglycerol (2-AG), respectively[1]. MJN110 produces opioid-sparing effects and displays strong antihyperalgesic activity[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1438416-21-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117474. | |
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