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| Product | Description | |
|---|---|---|
| 2-Arachidonoylglycerol | 2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 25.3-472 and 145-1,400 nM, respectively). Synonyms: 2-AG; 2-Arachidonoyl Glycerol; glyceryl 2-arachidonate; 2-Ara-Gl; MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0); 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol. Grades: >99%. CAS No. 53847-30-6. Molecular formula: C23H38O4. Mole weight: 378.55. |  |
| 2-Arachidonoylglycerol | 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand in the central nervous system. Uses: Scientific research. Group: Natural products. CAS No. 53847-30-6. Pack Sizes: 1 mg (26.4 mM * 100 μL in Acetonitrile). Product ID: HY-W011051. |  |
| 1-Monoarachidin | 1-Monoarachidin is a derivative of 2-Arachidonoylglycerol (A765050), an major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. Group: Biochemicals. Alternative Names: 1-Monoarachidonoyl-rac-glycerol; (all-Z)-(±)-2,3-Dihydroxypropyl 5,8,11,14-eicosatetraenoate; (all-Z)-5,8,11,14-Eicosatetraenoic Acid, 2,3-Dihydroxypropyl Ester; (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid, 2,3-Dihydroxypropyl Ester. Grades: Highly Purified. CAS No. 35474-99-8. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| 2-Linoleoyl glycerol | 2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Monolinolein; 2-Monolinoleoylglycerol. CAS No. 3443-82-1. Pack Sizes: 500 μg (14.10 mM * 100 μL in Methyl acetate); 1 mg (14.10 mM * 200 μL in Methyl acetate). Product ID: HY-130311. | |
| 2-Palmitoylglycerol | 2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119 [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Palm-Gl. CAS No. 23470-00-0. Pack Sizes: 25 mg; 50 mg; 5 mg; 10 mg. Product ID: HY-W013788. | |
| (3S,4S)-3-Hexyl-4-[(2S)-2-hydroxytridecyl]-2-oxetanone | (3S,4S)-3-Hexyl-4-[(2S)-2-hydroxytridecyl]-2-oxetanone is an analog of Tetrahydrolipstatin, an inhibitor of the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG), also an intermediate in the preparation of Orlistat. Group: Biochemicals. Alternative Names: [3S-[3α,4 β(R*)]]-3-Hexyl-4-(2-hydroxytridecyl)-2-oxetanone; (3S,4S)-3-Hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. Grades: Highly Purified. CAS No. 68711-40-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (3S,4S)-3-Hexyl-4-[(S)-2-hydroxytridecyl]-2-oxetanone | An analog of Tetrahydrolipstatin, an inhibitor of the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG), also an intermediate in the preparation of Orlistat. Synonyms: (3S,4S)-3-Hexyl-4-((S)-2-hydroxytridecyl)oxetan-2-one. CAS No. 68711-40-0. Molecular formula: C22H42O3. Mole weight: 354.57. | |
| (3S, 4S) -3-Hexyl-4[ (S) -2- (triisopropylsilyloxy) tridecyl]-2-oxetanone | A reagent used in the synthesis of enzymatic endocannabinoid 2-arachidonoylglycerol hydrolysis inhibitors and respective analogs. Group: Biochemicals. Alternative Names: (3S,4S)-. Grades: Highly Purified. CAS No. 1072902-84-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (5Z,8Z,11Z,14Z)-2-[[Tris(1-methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris (1-methylethyl) silyl]oxy]methyl]ethyl Ester | (5Z,8Z,11Z,14Z)-2-[[Tris(1-methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris (1-methylethyl) silyl]oxy]methyl]ethyl Ester is an intermediate in the synthesis of 2-Arachidonoylglycerol (A765050), an major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 223259-26-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Arachidonoyl serinol | Arachidonoyl Serinol is an amide bond-containing analogue of 2-arachidonoylglycerol, which exhibited weak CB1 receptor agonistic activity. 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain. It is a product of increased inositol phospholipid metabolism. Replacement of the sn-2 oxygen in the glycerol moiety of 2-AG with a nitrogen atom gives arachidonoyl serinol. Arachidonoyl serinol is much more stable than 2-AG. Synonyms: N-arachidonoyl dihydroxypropylamine; 183718-70-9; AA dihydroxypropylamine; (5Z,8Z,11Z,14Z)-N-(1,3-dihydroxypropan-2-yl)icosa-5,8,11,14-tetraenamide; CHEMBL141463; Arachidonoyl Serinol; N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(1,3-dihydroxy-propyl-2-amine); 5,8,11,14-Eicosatetraenamide,N-[2-hydroxy-1-(hydroxymethyl)ethyl]-, (5Z,8Z,11Z,14Z)-; N-[(2-Hydroxy-1-hydroxymethyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; Arachidonoylserinol; CHEBI:183197; QHELXIATGZYOIB-DOFZRALJSA-N; HMS3649C07; BDBM50054465; LMFA08020072; SR-01000946557; SR-01000946557-1; (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid (2-hydroxy-1-hydroxymethyl-ethyl)-amide. Grades: ≥98%. CAS No. 183718-70-9. Molecular formula: C23H39NO3. Mole weight: 377.6. | |
| CAY10499 | Monoglyceride lipase (MGL) plays an important role in the metabolism of the lipid transmitter 2-arachidonoylglycerol (2-AG). CAY10499 is a potent and selective monoglyceride lipase (MGL) inhibitor exhibiting an IC50 of 90 nM for the recombinant enzyme. It is also a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 mM, respectively). Synonyms: CAY-10499; CAY 10499; Magl-IN-5. Grades: ≥98%. CAS No. 359714-55-9. Molecular formula: C18H17N3O5. Mole weight: 355.34. | |
| JZL195 | JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. IC50 values are 2 nM for MAGL and 4 nM for FAAH. JZL195 has been shown to inhibit endocannabinoid hydrolysis and elevate 2-AG and AEA levels in vivo. Synonyms: JZL195; JZL-195; JZL 195. Grades: >98%. CAS No. 1210004-12-8. Molecular formula: C24H23N3O5. Mole weight: 433.46. | |
| KT109 | KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC 50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGL&alpha. KT109 shows inhibitory activity against PLA2G7 (IC 50 =1 μM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402612-55-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18540. | |
| MJN110 | MJN110 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor that modulates the synaptic processes. MJN110 has the potential for the treatment of acute nausea and vomiting as well as anticipatory nausea by elevation of endogenous cannabinoid 2-arachidonoylglycerol (2-AG) levels in the brain. Uses: Antihyperalgesic agent. Synonyms: MJN-110; MJN 110; MJN110;2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate. Grades: 98%. CAS No. 1438416-21-7. Molecular formula: C22H21Cl2N3O4. Mole weight: 462.33. | |
| Monoacylglycerol Lipase Inhibitor 21 | MAGL inhibitor 21 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL), an enzyme responsible for the inactivation of the endocannabinoid 2-arachidonoylglycerol (2-AG). It exhibits analgesic and tissue-protecting effects in animal models. Synonyms: MAGL Inhibitor 21; 1,3-Benzodioxol-5-ylmethyl 6-(4-phenylphenyl)hexanoate. Grades: ≥98%. CAS No. 1643657-35-5. Molecular formula: C26H26O4. Mole weight: 402.5. | |
| N-Arachidonyl maleimide | N-Arachidonyl maleimide (NAM) is a potent and irreversible inhibitor of monoacylglycerol lipase (MAGL), an enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). Synonyms: NAM; 1-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenyl]pyrrole-2,5-dione. Grades: ≥98%. CAS No. 876305-42-9. Molecular formula: C24H35NO2. Mole weight: 369.5. | |
| SAR629 | SAR-629 is a Monoglyceride lipase (MGL) inhibitor and can also be known as 2-arachidonoylglycerol (2-AG) degradation inhibitor. MGL is a serine hydrolase which can hydrolyse 2-AG into arachidonic acid and glycerol. 2-AG is an endogenous ligand of cannabinoid receptors and it plays an important role in various physiological processes in the brain. Synonyms: (4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)(1H-1,2,4-triazol-1-yl)methanone. Grades: 98%. CAS No. 1221418-42-3. Molecular formula: C20H19F2N5O. Mole weight: 383.40. | |
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