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2-C-Methyl-D-erythritol can be isolated from the extracts of Carum ajowan fruit and used as a glucide. Synonyms: 2-Methylerythritol; (2S,3R)-2-methylbutane-1,2,3,4-tetrol. Grades: 98.0%. CAS No. 58698-37-6. Molecular formula: C5H12O4. Mole weight: 136.147.
The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here). Group: Enzymes. Synonyms: MECDP-synthase; 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing). Enzyme Commission Number: EC 4.6.1.12. CAS No. 287480-92-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5349; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; EC 4.6.1.12; 287480-92-6; MECDP-synthase; 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing). Cat No: EXWM-5349.
2-C-Methyl-D-erythritol 4-phosphate
2-C-Methyl-D-erythritol 4-phosphate, a vital intermediary in isoprenoid biosynthesis, emerges as an imperative entity within the realm of biomedicine. Its multifarious applications extend to the creation of pharmaceutical agents combating diverse ailments such as cancer, infectious diseases, and cardiovascular maladies. Profoundly entwined with the orchestration of cellular mechanisms, this compound unravels as an invaluable asset in the biomedical domain. Synonyms: Methyl-D-erythritol Phosphate; 206440-72-4; 2-C-Methyl-D-erythritol 4-phosphate; [(2R,3S)-2,3,4-trihydroxy-3-methylbutyl] dihydrogen phosphate; 2-C-Methylerythritol 4-phosphate; 1,2,3,4-Butanetetrol, 2-methyl-, 4-(dihydrogen phosphate), (2S,3R)-; 2-C-methyl-D-erythritol 4-(dihydrogen phosphate); (2R,3S)-2,3,4-trihydroxy-3-methylbutyl dihydrogen phosphate; CHEBI:17764; SCHEMBL345740; DTXSID90332064; 2-C-methyl-D-erythritol-4-phosphate; Q2709086. CAS No. 206440-72-4. Molecular formula: C5H13O7P. Mole weight: 216.13.
The enzyme from Escherichia coli requires Mg2+ or Mn2+. ATP or UTP can replace CTP, but both are less effective. GTP and TTP are not substrates. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here). Group: Enzymes. Synonyms: MEP cytidylyltransferase. Enzyme Commission Number: EC 2.7.7.60. CAS No. 251990-59-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3272; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; EC 2.7.7.60; 251990-59-7; MEP cytidylyltransferase. Cat No: EXWM-3272.
The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective. The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here). The mechanism has been shown to be a retroaldol/aldol reaction. Group: Enzymes. Synonyms: DXP-reductoisomerase; 1-deoxy-D-xylulose-5-phosphate isomeroreductase; 2-C-methyl-D-erythritol 4-phosphate (MEP) synthase. Enzyme Commission Number: EC 1.1.1.267. CAS No. 210756-42-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0173; 1-deoxy-D-xylulose-5-phosphate reductoisomerase; EC 1.1.1.267; 210756-42-6; DXP-reductoisomerase; 1-deoxy-D-xylulose-5-phosphate isomeroreductase; 2-C-methyl-D-erythritol 4-phosphate (MEP) synthase. Cat No: EXWM-0173.
An iron-sulfur protein that contains either a [3Fe-4S] or a [4Fe-4S] cluster. This enzyme forms a system with a ferredoxin or a flavodoxin and an NAD(P)H-dependent reductase. This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis. This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts. The enzyme acts in the reverse direction, producing a 5:1 mixture of isopentenyl diphosphate and dimethylallyl diphosphate. Group: Enzymes. Synonyms: isopentenyl-diphosphate:NADP+ oxidoreductase; LytB; (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase; HMBPP reductase; IspH; LytB/IspH. Enzyme Commission Number: EC 1.17.7.4. CAS No. 512789-14-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1099; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase; EC 1.17.7.4; 512789-14-9; isopentenyl-diphosphate:NADP+ oxidoreductase; LytB; (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase; HMBPP reductase; IspH; LytB/IspH. Cat No: EXWM-1099.
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