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| Product | Description | |
|---|---|---|
| 2-Chloro-5-nitro-N-4-pyridinylbenzamide | 2-Chloro-5-nitro-N-4-pyridinylbenzamide. Group: Biochemicals. Alternative Names: T0070907. Grades: Highly Purified. CAS No. 313516-66-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C12H8ClN3O3. US Biological Life Sciences. |  Worldwide |
| 2-Chloro-5-nitro-N-4-pyridinylbenzamide (T0070907) | A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85uM and 1.8uM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain. Group: Biochemicals. Alternative Names: T0070907. Grades: Highly Purified. CAS No. 313516-66-4. Pack Sizes: 5mg, 10mg, 25mg, 100mg. Molecular Formula: C12H8ClN3O3. US Biological Life Sciences. | Worldwide |
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